The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution
Open accessAbstract
Targeted biologic therapies have revolutionised treatment of immune-mediated inflammatory diseases (IMIDs) due to their efficacy, speed of onset and tolerability. The discovery that clinically unrelated conditions, such as rheumatoid arthritis and Crohn's disease, share similar immune dysregulation has led to a shift in the management of IMIDs from one of organ-based symptom relief to mechanism-based treatment. The fact that anticytokine therapy has been effective in treating multiple orphan inflammatory conditions confirms the IMID paradigm. In this review we examine the biologic agents currently licensed for use in the US and Europe: infliximab, etanercept, adalimumab, rituximab, abatacept, anakinra, alefacept and efalizumab. We also discuss the rationale behind the management of IMIDs using rheumatoid arthritis, Crohn's disease, psoriasis and psoriatic arthritis as examples. For the medical profession, IMID represents a breakthrough in the way pathology is classified. In this burgeoning era of biologic therapy the prospect of complete disease remission is conceivable.
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Cites
Targan, S. R., Hanauer, S. B., van Deventer, S. J. H., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F., & Rutgeerts, P. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710093371502 · Cited by 3,135
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Cited by
Jørgensen, K. K., Olsen, I. C., Goll, G. L., Lorentzen, M., Bolstad, N., Haavardsholm, E. A., Lundin, K. E. A., Mørk, C., Jahnsen, J., Kvien, T. K., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30068-5 · Cited by 818
TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme
Verstrepen, L., Bekaert, T., Chau, T.-L., Tavernier, J., Chariot, A., & Beyaert, R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8064-8 · Cited by 440
Immune-mediated inflammatory diseases: common and different pathogenic and clinical features
Monteleone, G., Moscardelli, A., Colella, A., Marafini, I., & Salvatori, S. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103410 · Cited by 105
Metadata
- Authors
- Kuek, A., Hazleman, B. L., & Östör, A. J. K.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-01
- Volume
- 83
- Issue
- 978
- Pages
- 251-260
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W1967570746
- Cited by
- 335
- References
- 2
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuek, A., Hazleman, B. L., & Östör, A. J. K. (2007). Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution. Postgraduate Medical Journal. https://doi.org/10.1136/pgmj.2006.052688
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