Cardiovascular disease in cancer survivors
Abstract
Certain cancer therapies, including radiation therapy and some types of chemotherapies, are associated with increased risk of cardiovascular disease (CVD) and events. Some of these effects such as those presented by anthracyclines, radiation therapy, cisplatin, as well as those presented by hormone therapy for breast cancer—usually taken for many years for some breast and prostate cancers—are long-lasting and associated with cardiovascular events risk more than 20 years after cancer treatment. Cardiovascular testing, diagnostic assessment of suspected cardiovascular symptomatology, as well as laboratory tests for CVD risk factors are imperative. The early recognition and treatment of CVD processes that arise in survivorship years is pivotal, with specific attention to some CVD processes with specific suggested treatment modalities. Preventive measures include adequate screening, the use of medications such as ACE inhibitors/angiotensin receptor blockers and/or beta blockers, statin therapy and aspirin in persons who warrant these medications, as well as therapeutic lifestyle modifications such as exercise/physical activity, weight loss and appropriate diet for a healthy lifestyle. Periodic follow-up with a good primary care physician who understands the risks associated with cancer therapy is important, and referral to onco-cardiology for further management of cardiovascular risk in these survivors is based on a patient’s cardiovascular risk level and the type, amount and duration of cancer therapies received during the patient’s lifetime.
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Abrams, L., Bramajo, O., van Raalte, A., Myrskylä, M., & Mehta, N. K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2519356123 · Cited by 6 · see citing works
- Authors
- Okwuosa, T. M., Anzevino, S., & Rao, R.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Rao, Ruta
- ORCID
- Rao, Ruta
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-08
- Volume
- 93
- Issue
- 1096
- Pages
- 82-90
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W2528936641
- Cited by
- 97
- References
- 88
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 18 · 2023: 11 · 2022: 16 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 3 · 2017: 4
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- cancer survivors, cardiovascular disease, anthracycline cardiotoxicity, radiation-induced cardiotoxicity, hormone therapy, breast cancer, prostate cancer, cardiovascular risk screening, statin therapy, ACE inhibitors, beta-blockers, aspirin, lifestyle modification, cardio-oncology
- MeSH terms
- Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Cardiovascular Diseases, Humans, Neoplasms, Radiotherapy, Risk Factors, United States, Practice Guidelines as Topic, Survivors, Risk Reduction Behavior, Early Diagnosis
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