Speech and language therapy approaches to managing primary progressive aphasia
Open accessAbstract
The term primary progressive aphasia (PPA) describes a group of neurodegenerative disorders with predominant speech and language dysfunction as their main feature. There are three main variants – the semantic variant, the nonfluent or agrammatic variant and the logopenic variant – each with specific linguistic deficits and different neuroanatomical involvement. There are currently no curative treatments or symptomatic pharmacological therapies. However, speech and language therapists have developed several impairment-based interventions and compensatory strategies for use in the clinic. Unfortunately, multiple barriers still need to be overcome to improve access to care for people with PPA, including increasing awareness among referring clinicians, improving training of speech and language therapists and developing evidence-based guidelines for therapeutic interventions. This review highlights this inequity and the reasons why neurologists should refer people with PPA to speech and language therapists.
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Substantial progress has been made to improve language symptoms in frontotemporal dementia.
“Substantial progress has been made to improve language symptoms.73”
From Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations (2022) · cites this paper as [73]
The Impairment-based approaches section reports improvements in word retrieval and speech production after therapy for people with primary progressive aphasia, and the Conclusion says the research literature is rapidly developing. The paper does not establish comparable progress for language symptoms across frontotemporal dementia generally; its treatment evidence concerns primary progressive aphasia, some cases of which have Alzheimer’s disease pathology (Introduction). (LLM, conf=0.82)
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Boeve, B. F., Boxer, A. L., Kumfor, F., Pijnenburg, Y., & Rohrer, J. D. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00341-0 · Cited by 218 · see citing works
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- Authors
- Volkmer, A., Rogalski, E., Henry, M., Taylor-Rubin, C., Ruggero, L., Khayum, R., Kindell, J., Gorno-Tempini, M. L., Warren, J. D., & Rohrer, J. D.
- Affiliations
- University College London (GB)
- Northwestern University (US)
- The University of Texas at Austin (US)
- Department of Cognitive Science, Macquarie University, Sydney, New South Wales, Australia
- Macquarie University (AU)
- Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, UK
- Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, USA
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Rohrer, Jonathan D
- Venue
- Practical Neurology
- Publisher
- BMJ
- Published
- 2019-07-29
- Volume
- 20
- Issue
- 2
- Pages
- 154-161
- ISSN
- 1474-7758 (ISSN-L)
- 1474-7766
- PMC
- PMC6986989
- OpenAlex
- W2965519052
- Cited by
- 126
- References
- 46
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 17 · 2023: 27 · 2022: 18 · 2021: 14 · 2020: 9 · 2019: 2
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Practical Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Medical Research Council (MR/M008525/1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Keywords
- primary progressive aphasia, speech therapy, semantic variant PPA, logopenic variant PPA, compensatory strategies, health care access, clinician awareness, evidence-based recommendations, neurodegenerative diseases
- MeSH terms
- Humans, Language Therapy, Speech Therapy, Aphasia, Primary Progressive, Disease Management
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