The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study.
Abstract
Objective To determine the prevalence of asymptomatic neurosyphilis (ANS) in HIV-positive individuals after treatment of early syphilis with single-dose benzathine penicillin G (BPG) or oral antibiotic alternatives. Methods Patients at high risk of neurosyphilis (defined by serum rapid plasma reagin (RPR) titre ≥1:32 and/or peripheral blood CD4 lymphocyte count ≤350/μL) underwent lumbar puncture (LP) at a median time of 8.2 months post treatment. ANS was diagnosed by a reactive cerebrospinal fluid (CSF) RPR test or CSF white blood cells (WBC) >20/μL plus a reactive CSF Treponema pallidum particle agglutination (TPPA) ≥1:640. Results Of 133 eligible patients, all were men who have sex with men. Of these, 64 consented to LP. Full CSF results were available for 59 patients. Inclusion criteria were serum RPR (21/59), CD4 count (22/59) and combined RPR and CD4 (16/59). The LP patients were white British (82%), median age 40. Syphilis stages were primary (17%) secondary (43%) and early latent (41%). Syphilis was treated with BPG (47/59), doxycycline 100 mg two times per day for 14 days (10/59) and for 21 days (1/59). Azithromycin 500 mg one time per day for 10 days was given to 1/59. At the time of LP, 100% of patients had achieved serological cure, and 66% were taking antiretroviral treatment. Only 1/59 was diagnosed with ANS. The CSF showed: RPR non-reactive (59/59); TPPA non-reactive in 54/59; WBC ≤5/μL in 51/59. Conclusions Although the number of patients in our study is modest, single-dose BPG appears to be highly effective even in patients at high risk of neurosyphilis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The majority of persons with HIV infection respond appropriately to the recommended benzathine penicillin G treatment regimen for primary and secondary syphilis.
“The majority of persons with HIV infection respond appropriately to the recommended benzathine penicillin G treatment regimen for primary and secondary syphilis (626).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [626]
Most individuals who have symptomatic neurosyphilis have a raised white cell count (>5 cells/mm3) in the CSF, although in cases of parenchymous neurosyphilis this may not be the case.
“Most individuals who have symptomatic neurosyphilis have a raised white cell count (>5 cells/mm3) in the CSF,70 although in cases of parenchymous neurosyphilis this may not be the case.71”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [70]
Citations
Cites
Gazzard, B., & on behalf of the BHIVA Treatment Guidelines Writing Group (2008) · HIV Medicine · doi:10.1111/j.1468-1293.2008.00636.x · Cited by 1,090
Marra, C. M., Maxwell, C. L., Smith, S. L., Lukehart, S. A., Rompalo, A. M., Eaton, M., Stoner, B. P., Augenbraun, M., Barker, D. E., Corbett, J. J., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/381227 · Cited by 491
Marra, C. M., Sahi, S. K., Tantalo, L. C., Godornes, C., Reid, T. B., Behets, F., Rompalo, A. M., Klausner, J. D., Yin, Y., Mulcahy, F. M., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/656533 · Cited by 229
UK National Guidelines on the Management of Syphilis 2008
Kingston, M., French, P., Goh, B. T., Goold, P., Higgins, S. P., Sukthankar, A., Stott, C., Turner, A. J., Tyler, C., & Young, H.-K. (2008) · International Journal of STD & AIDS · doi:10.1258/ijsa.2008.008279 · Cited by 195
Self-citationCXCL13 as a Cerebrospinal Fluid Marker for Neurosyphilis in HIV-Infected Patients With Syphilis
Marra, C. M., Tantalo, L. C., Sahi, S. K., Maxwell, C. L., & Lukehart, S. A. (2010) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e3181d877a1 · Cited by 137
Marra, C. M., Tantalo, L. C., Maxwell, C. L., Ho, E. L., Sahi, S. K., & Jones, T. (2012) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e31824b1cde · Cited by 114
Significance of laboratory findings for the diagnosis of neurosyphilis
Luger, A. F., Schmidt, B. L., & Kaulich, M. (2000) · International Journal of STD & AIDS · doi:10.1258/0956462001915750 · Cited by 87
Clinical Prediction and Diagnosis of Neurosyphilis in HIV-Infected Patients with Early Syphilis
Dumaresq, J., Langevin, S., Gagnon, S., Serhir, B., Deligne, B., Tremblay, C. L., Tsang, R. S. W., Fortin, C., Coutlée, F., & Roger, M. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.01989-13 · Cited by 72
Toll-Like Receptor Polymorphisms Are Associated With Increased Neurosyphilis Risk
Marra, C. M., Sahi, S. K., Tantalo, L. C., Ho, E. L., Dunaway, S. B., Jones, T., & Hawn, T. R. (2014) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000000149 · Cited by 49
Std, I. J., O’Farrell, N., & Daniels, D. (2013) · Cited by 20
Flagged first, then by citations
Research works printed but not linked: 1
- Larsen SA , Hambie EA , Wobig GH , et al . Cerebrospinal fluid serologic test for syphilis: treponemal and non-treponemal tests. In: Morisset R , Kurstak E, eds . Advances in sexually transmitted diseases. Utrecht, The Netherlands: VNU Science Press, 1986:157–62.
Cited by
Sorted by citations
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
BASHH UK guidelines for the management of syphilis 2024
Kingston, M., Apea, V., Evans, C., Fifer, H., Foster, K., Patrick, P., Grant, A., Manns, V., Ramsden, S., Sinka, K., et al. (2024) · International Journal of STD & AIDS · doi:10.1177/09564624241280406 · Cited by 51
Metadata
- Authors
- Tomkins, A., Ahmad, S., Cousins, D. E., Thng, C. M., Vilar, F. J., & Higgins, S. P.
- Affiliations
- Pennine Acute Hospitals NHS Trust (GB)
- Corresponding author
- Tomkins, Andrew
- Venue
- Sexually Transmitted Infections
- Publisher
- BMJ
- Published
- 2017-02-14
- Volume
- 94
- Issue
- 5
- Pages
- 337-339
- ISSN
- 0007-134X (ISSN-L)
- 1368-4973
- 1472-3263
- OpenAlex
- W2587973188
- Cited by
- 27
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Infections (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- asymptomatic neurosyphilis, HIV, early syphilis, benzathine penicillin G, TPPA, doxycycline, azithromycin, men who have sex with men, CD4 count
- MeSH terms
- Adult, Anti-Bacterial Agents, England, Humans, Male, Neurosyphilis, Penicillin G Benzathine, Risk Factors, Syphilis, Syphilis Serodiagnosis, Treponema pallidum, HIV Infections, Prevalence, Homosexuality, Male, CD4 Lymphocyte Count, Asymptomatic Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
