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Cited by 22Antibiotics Pharmacokinetics and EfficacySyphilis Diagnosis and TreatmentHistorical Medical Research and Treatments

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Open access
Collart, P, Poitevin, M, Milovanovic, A, Herlin, A, Durel, J·1980·Sexually Transmitted Infections
DOI 10.1136/sti.56.6.355PMC PMC1045831
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Abstract

In a comparative kinetic study of the serum concentrations of two penicillin complexes--medium-long-acting (benethamine penicillin) and long-acting (benzathine bipenicillin)--after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in the serum; (b) the penicillin was absorbed faster in young than in elderly subjects even when a long-acting complex was used; (c) serum concentrations below the level regarded as lethal for treponemes appeared much earlier and more frequently in young than in old people; and (d) the bioequivalence between penicillin preparations could not be estimated solely for the number of units of the agent used but from the bioavailability of the chosen formulation. Thus a uniform and standard penicillin dosage allowing no safety margin may help in the superficial healing of a syphilitic chancre or the resolution of a roseola but it will certainly be insufficient to kill Treponema pallidum. It seems essential therefore to provide an antibiotic cover at high dosage over a long period of time.

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Research works printed but not linked: 30

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  17. Collart P. Critique des elements de base sur lesquels reposent certains traitements de la syphilis. Sem Hop 1974;50:673-9.
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Metadata

Authors
Collart, P., Poitevin, M., Milovanovic, A., Herlin, A., & Durel, J.
Affiliations
Institut Alfred Fournier (FR)
Venue
Sexually Transmitted Infections
Publisher
BMJ
Published
1980-12-01
Volume
56
Issue
6
Pages
355-362
ISSN
  • 0007-134X (ISSN-L)
  • 1368-4973
DOI
10.1136/sti.56.6.355
PMC
PMC1045831
OpenAlex
W1976544368
Cited by
22
References
44
Citations by year
2023: 3 · 2021: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Sexually Transmitted Infections (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
  • Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords
benzathine penicillin, pharmacokinetics, age differences, elderly patients, bioequivalence, bioavailability, Treponema pallidum, syphilis, chancre, roseola, antibiotic dosing
MeSH terms
Adult, Age Factors, Aged, Biological Availability, Drug Administration Schedule, Female, Humans, Kinetics, Male, Middle Aged, Penicillin G, Penicillin G Benzathine, Penicillins, Syphilis

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