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Cited by 22Antibiotics Pharmacokinetics and EfficacySyphilis Diagnosis and TreatmentHistorical Medical Research and Treatments

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Open access
Collart, P, Poitevin, M, Milovanovic, A, Herlin, A, Durel, J·1980·Sexually Transmitted Infections
DOI 10.1136/sti.56.6.355PMC PMC1045831
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Abstract

In a comparative kinetic study of the serum concentrations of two penicillin complexes--medium-long-acting (benethamine penicillin) and long-acting (benzathine bipenicillin)--after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in the serum; (b) the penicillin was absorbed faster in young than in elderly subjects even when a long-acting complex was used; (c) serum concentrations below the level regarded as lethal for treponemes appeared much earlier and more frequently in young than in old people; and (d) the bioequivalence between penicillin preparations could not be estimated solely for the number of units of the agent used but from the bioavailability of the chosen formulation. Thus a uniform and standard penicillin dosage allowing no safety margin may help in the superficial healing of a syphilitic chancre or the resolution of a roseola but it will certainly be insufficient to kill Treponema pallidum. It seems essential therefore to provide an antibiotic cover at high dosage over a long period of time.

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Citations

Cites

Research works printed but not linked: 30

  1. Willcox, RR. Treatment of early venereal syphilis. Br J Vener Dis 1962;38:109-23.
  2. Huriez C, Desmons F, Fossati-Delescluse, R. Etude th&apeutique et mrtabolique de la benethamine-penicilline. Bull Soc Fr Dermatol Syphilol 1964;71:643-4.
  3. Graciansky P de, Grupper C. Resultats du traitement de la syphilis primo-secondaire par l'injection unique de penicilline long-retard (a propos de 147 malades). Bull Soc Dermatol Syphilol 1959;5:699-710.
  4. Graciansky P de, Grupper C. La benethamine dans le traitement des syphilis recentes. Bull Soc Dermatol Syphilol 1963;70: 17.
  5. Siboulet A, Busquet PY, Egger L, Majewski E. Gonococcie et syphilis. Bull Soc Dermatol Syphilol 1973; 80:642-5.
  6. United States Public Health Service. Center for Disease Control recommended treatment schedules for syphilis. Curr Lit VenerDis 1976; 1:8-10.
  7. Dayer P, Balant L. La pharmacologie clinique pourquoi? Med Hyg 1978;36:997-8.
  8. Simon C, Malerczykiv V, Muller U, Muller G. Zur pharmakokinetik von propicillin bei geriatrischen patienten in vergleich zujungeren eerwaschsenen.' Dtsch Med Wochenschr 1972; 52: 1999-2003.
  9. Clini V, Mars G, Tansini G. La distribuzione di alcuni antibiotici in soggeti di varia eta. La Settimana Medica 1964; 52: 1007-24.
  10. Bouchon JP. L'emploi des antibiotiques chez les vieillards. In: Bourliere F, ed. Progres en Gerontologie. Paris: Editions Medicales Flammarion 1969:249-263.
  11. Food and Drug Administration. Proposed bioavailability requirements. Federal Register 1973; 38:885-7.
  12. Hirtz J. La disponibilite biologique des medicaments. Actual Pharmacol 1976; 28:76-106.
  13. Dagher et al. Nomogramme pour la determination des volumes sanguin, plasmatique et globulaire a partir de l'age et du poids corporel de l'adulte. Adv Surg 1965; 1:69.
  14. Hirtz J, Schoeller JP. Interet clinique du dosage des medicaments dans le sang. Nouv Presse Med 1976; 5:869-72.
  15. Chabbert Y, Boulingre H. Modifications pratiques concernant le dosage des antibiotiques en clinique. Rev Fr Etudes Clin Biol 1957; 1:636-40.
  16. Brogard JM, Pinget M, Dorner M, Lavillaureix J. Etablissement du profil pharmacocinetique d'un antibiotique. Interet pratique et applications a l'etude comparative des cephalosporines. Bull Inst Pasteur 1976; 74:383-412.
  17. Collart P. Critique des elements de base sur lesquels reposent certains traitements de la syphilis. Sem Hop 1974;50:673-9.
  18. Eagle H. The dynamics of penicillin action to its use in the treatment of syphilis. Recapitulation of the experimental data. In: Symposium on Current Progress in the Study of Venereal Diseases. Washington DC: Division of Venereal Diseases, United States Public Health Service, 1949:272-6.
  19. Eben-Moussi E, Van den Driessche J. Pharmaco-cinetique des antibiotiques dans l'organisme humain. Anest Anal Rean 1971; 28:671-87.
  20. Boissier JR, Advenier C. Resorption des medicaments. Concours Medical 1976; 98:6613-73.
  21. Benazet F, Dubost M, Jolles G, Leau 0, Pascal C, Preud'Homme J, Terlain B. Liaisons et modifications des antibiotiques in vivo (sang et foyer infectieux). Biol Med 1968;57: 1-26.
  22. Vignalou J. Generalites sur la th&rapeutique en g&riatrie. Cah Med 1974;15 (9), 573-8.
  23. Paychere JMW Geronto-pharmacologie. Medecine et Hygiene 1978;36: 1043-53.
  24. Rolinson GN. The significance of protein binding of antibiotics in vitro and in vivo. In: Waterson AP, ed. Recent Advances in Medical Microbiology, Chap 7. London: J & A Churchill, 1967:254-83.
  25. Tinelli R. Le glycopeptide des parois bacteriennes. Bull Inst Pasteur 1968; 66:2507-38.
  26. Heite HJ. Beitrag zur verteilung des penicillins im savgetierorganismus. Klin Wochenschr 1952; 30:174-5.
  27. Balant L, Dayer P. I1 n'y a pas de relation entre les taux sanguins et l'effet du medicament. Medecine et Hygiene 1978;36: 1029-38.
  28. Collart P. Le treponeme pale. Rev Med 1970; 11: 1265-300.
  29. Collart P, Poitevin M. Le probleme des treponemes penicillinoresistants. Sem Hop Paris 1975; 51:1489-96.
  30. Collart P, Poitevin M. Donnees r&entes sur le comportement des treponemes pales. Revue du Praticien (Paris) 1976; 26:4065-76.

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Metadata

Authors
Collart, P., Poitevin, M., Milovanovic, A., Herlin, A., & Durel, J.
Affiliations
Institut Alfred Fournier (FR)
Venue
Sexually Transmitted Infections
Publisher
BMJ
Published
1980-12-01
Volume
56
Issue
6
Pages
355-362
ISSN
  • 0007-134X (ISSN-L)
  • 1368-4973
DOI
10.1136/sti.56.6.355
PMC
PMC1045831
OpenAlex
W1976544368
Cited by
22
References
44
Citations by year
2023: 3 · 2021: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Sexually Transmitted Infections (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
  • Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Keywords
benzathine penicillin, pharmacokinetics, age differences, elderly patients, bioequivalence, bioavailability, Treponema pallidum, syphilis, chancre, roseola, antibiotic dosing
MeSH terms
Adult, Age Factors, Aged, Biological Availability, Drug Administration Schedule, Female, Humans, Kinetics, Male, Middle Aged, Penicillin G, Penicillin G Benzathine, Penicillins, Syphilis

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