Cited by 226Asthma and respiratory diseasesOccupational exposure and asthmaInflammatory mediators and NSAID effects

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Frequent paracetamol use and asthma in adults

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Shaheen, S. O·2000·Thorax

DOI 10.1136/thorax.55.4.266PMC PMC1745727

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Abstract

BACKGROUND: The pulmonary antioxidant glutathione may limit airway inflammation in asthma. Since paracetamol (acetaminophen) depletes the lung of glutathione in animals, a study was undertaken to investigate whether frequent use in humans was associated with asthma. METHODS: Information was collected on the use of analgesics as part of a population based case-control study of dietary antioxidants and asthma in adults aged 16-49 years registered with 40 general practices in Greenwich, South London. The frequency of use of paracetamol and aspirin was compared in 664 individuals with asthma and in 910 without asthma. Asthma was defined by positive responses to questions about asthma attacks, asthma medication, or waking at night with shortness of breath. The association between analgesic use and severity of disease amongst asthma cases, as measured by a quality of life score, was also examined. RESULTS: Paracetamol use was positively associated with asthma. After controlling for potential confounding factors the odds ratio for asthma, compared with never users, was 1.06 (95% CI 0.77 to 1.45) in infrequent users (

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Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies
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Authors: Shaheen, S. O.
Affiliations: King's College London (GB)
Corresponding author: Shaheen, S. O
ORCID: Shaheen, S. O
Venue: Thorax
Publisher: BMJ
Published: 2000-04-01
Volume: 55
Issue: 4
Pages: 266-270
ISSN: 0040-6376 (ISSN-L)
DOI: 10.1136/thorax.55.4.266
PMC: PMC1745727
OpenAlex: W2025295475
Cited by: 226
References: 34
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 14 · 2012: 9
FWCI: 8.80
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Thorax (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: paracetamol, asthma, aspirin, analgesic use, glutathione depletion, airway inflammation, dietary antioxidants, asthma severity, quality of life, adults
MeSH terms: Acetaminophen, Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Asthma, Glutathione, United Kingdom, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies, Analgesics, Non-Narcotic

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Frequent paracetamol use and asthma in adults

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