The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Randomised trial of intrapleural urokinase in the treatment of childhood empyema
Open accessAbstract
BACKGROUND: The role of intrapleural fibrinolytic agents in the treatment of childhood empyema has not been established. A randomised double blind placebo controlled trial of intrapleural urokinase was performed in children with parapneumonic empyema. METHODS: Sixty children (median age 3.3 years) were recruited from 10 centres and randomised to receive either intrapleural urokinase 40 000 units in 40 ml or saline 12 hourly for 3 days. The primary outcome measure was length of hospital stay after entry to the trial. RESULTS: Treatment with urokinase resulted in a significantly shorter hospital stay (7.4 v 9.5 days; ratio of geometric means 1.28, CI 1.16 to 1.41 p=0.027). A post hoc analysis showed that the use of small percutaneous drains was also associated with shorter hospital stay. Children treated with a combination of urokinase and a small drain had the shortest stay (6.0 days, CI 4.6 to 7.8). CONCLUSION: Intrapleural urokinase is effective in treating empyema in children and significantly shortens hospital stay.
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Cites
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Walter, S. D., & Altman, D. G. (1992) · Biometrics · doi:10.2307/2532320 · Cited by 11,668
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
Practical Statistics for Medical Research.
Bartko, J. J., & Altman, D. G. (1992) · Journal of the American Statistical Association · doi:10.2307/2290246 · Cited by 4,797
Tillett, W. S., & Sherry, S. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102046 · Cited by 397
Physiology and pathophysiology of pleural fluid turnover
Miserocchi, G. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10010219 · Cited by 315
The Role of Clinical Opinion Leaders in Guideline Implementation and Quality Improvement
Borbas, C., Morris, N., McLaughlin, B., ASINGER, R. W., & Gobel, F. L. (2000) · CHEST Journal · doi:10.1378/chest.118.2_suppl.24s · Cited by 131
Metadata
- Authors
- Thomson, A. H.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2002-04-01
- Volume
- 57
- Issue
- 4
- Pages
- 343-347
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2161739935
- Cited by
- 305
- References
- 6
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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