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Cited by 449Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

Risk of depression in patients with chronic obstructive pulmonary disease and its determinants

Open access
van Manen, J G·2002·Thorax
DOI 10.1136/thorax.57.5.412PMC PMC1746339
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Abstract

BACKGROUND: Although it has been repeatedly suggested that chronic obstructive pulmonary disease (COPD) is associated with depression, no conclusion has so far been reached. A study was undertaken to investigate whether depression occurs more often in patients with COPD than in controls. The demographic and clinical variables associated with depression were also determined. METHODS: Patients with a registered diagnosis of obstructive airway disease in general practice, aged > or=40 years, forced expiratory volume in 1 second (FEV(1)) <80% predicted, FEV(1) reversibility <or =12%, FEV(1)/VC < or = predicted - 1.64 x SD, and a history of smoking were selected. A random sample of subjects without a registered diagnosis of asthma or COPD aged 40 years or older acted as controls. Depression was assessed using the Centers for Epidemiologic Studies Depression (CES-D) scale. RESULTS: In patients with severe COPD (FEV(1) <50% predicted), the prevalence of depression was 25.0% compared with 17.5% in controls and 19.6% in patients with mild to moderate COPD. When the results were adjusted for demographic variables and comorbidity, the risk for depression was 2.5 times greater for patients with severe COPD than for controls (OR 2.5, 95% CI 1.2 to 5.4). In patients with mild to moderate COPD this increased risk of depression was not seen. Living alone, reversibility of FEV(1) % predicted, respiratory symptoms and physical impairment were significantly associated with the scores on the CES-D scale. CONCLUSION: Patients with severe COPD are at increased risk of developing depression. The results of this study underscore the importance of reducing symptoms and improving physical functioning in patients with COPD.

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  • In stable COPD, the prevalence of anxiety ranges between 10% and 19%.

    “In stable COPD, the prevalence of clinical depression ranges between 10% and 42%, while that of anxiety ranges between 10% and 19% (Table 2).6–25”

    From Anxiety and Depression in COPD (2008) · cites this paper as [7]

  • In stable COPD, the prevalence of clinical depression ranges between 10% and 42%.

    “In stable COPD, the prevalence of clinical depression ranges between 10% and 42%, while that of anxiety ranges between 10% and 19% (Table 2).6–25”

    From Anxiety and Depression in COPD (2008) · cites this paper as [7]

  • The risk of depression is higher in patients with severe COPD compared to control subjects (odds ratio, 2.5; 95% confidence interval, 1.2 to 5.4).

    “The risk of depression (odds ratio, 2.5; 95% confidence interval, 1.2 to 5.4) is higher in patients with severe COPD compared to control subjects,7”

    From Anxiety and Depression in COPD (2008) · cites this paper as [7]

  • Depression among patients in PR is often evident in typical symptoms such as hopelessness and pessimism, as well as in less obvious symptoms such as difficulties with concentration and increased social withdrawal.

    “Depression among patients in PR is often evident in typical symptoms such as hopelessness and pessimism, as well as in less obvious symptoms such as difficulties with concentration and increased social withdrawal.7”

    From Anxiety and Depression in COPD (2008) · cites this paper as [7]

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1 of the 21 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Siafakas NM, Vermeire P, Pride NB, et al. ERS consensus statement. Optimal assessment and management of chronic obstructive pulmonary disease. Eur Respir J 1995;8:1398-420.

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Authors
van Manen, J. G.
Venue
Thorax
Publisher
BMJ
Published
2002-05-01
Volume
57
Issue
5
Pages
412-416
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thorax.57.5.412
PMC
PMC1746339
OpenAlex
W2139415488
Cited by
449
References
21
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 14 · 2021: 10 · 2020: 15 · 2019: 16 · 2018: 23 · 2017: 14 · 2016: 19 · 2015: 17 · 2014: 29 · 2013: 32 · 2012: 16
FWCI
15.31
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • Universiteit Leiden
  • Universiteit van Amsterdam
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
chronic obstructive pulmonary disease, depression, depression prevalence, disease severity, FEV1 reversibility, living alone, respiratory symptoms, physical impairment, comorbidities, risk factors, physical function
MeSH terms
Adult, Aged, Depressive Disorder, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Risk Factors, Vital Capacity, Pulmonary Disease, Chronic Obstructive

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