The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry

O'Neill, S.; Sweeney, J.; Patterson, C. C.; Menzies-Gow, A.; Niven, R.; Mansur, A. H.; Bucknall, C.; Chaudhuri, R.; Thomson, N. C.; Brightling, C. E.; O'Neill, C.; Heaney, L. G.; on behalf of the British Thoracic Society Difficult Asthma Network

doi:10.1136/thoraxjnl-2013-204114

Cited by 186Asthma and respiratory diseasesHealth Systems, Economic Evaluations, Quality of LifeOccupational exposure and asthma

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The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry

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O'Neill, S., Sweeney, J., Patterson, C. C., Menzies-Gow, A., Niven, R., Mansur, A. H., Bucknall, C., Chaudhuri, R., Thomson, N. C., Brightling, C. E., O'Neill, C., Heaney, L. G., on behalf of the British Thoracic Society Difficult Asthma Network·2015·Thorax

DOI 10.1136/thoraxjnl-2013-204114

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Abstract

Severe refractory asthma poses a substantial burden in terms of healthcare costs but relatively little is known about the factors which drive these costs. This study uses data from the British Thoracic Society Difficult Asthma Registry (n=596) to estimate direct healthcare treatment costs from an National Health Service perspective and examines factors that explain variations in costs. Annual mean treatment costs among severe refractory asthma patients were £2912 (SD £2212) to £4217 (SD £2449). Significant predictors of costs were FEV1% predicted, location of care, maintenance oral corticosteroid treatment and body mass index. Treating individuals with severe refractory asthma presents a substantial cost to the health service.

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Breathlessness is an important outcome in asthma because it provides the patient with an alarm signal and is a vital component of self-monitoring.
“Breathlessness is an important outcome in asthma since it provides the patient with an alarm signal, making a vital component of self-monitoring [1,23].”
From A randomised controlled feasibility trial of Group Cognitive Behavioural Therapy for people with severe asthma (2017) · cites this paper as [1]
The Introduction describes an analysis of severe refractory asthma treatment costs, and the Methods and Results address healthcare use and cost drivers. Searches for breathlessness as an alarm signal or component of patient self-monitoring found no passage addressing that claim in our copy. (LLM, conf=0.76)
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S64 The Cost of Refractory Asthma in the UK - a Preliminary Analysis
O’Neill, S., Sweeney, J., Neill, C. O., Brightling, C. E., Menzies-Gow, A. N., Niven, R. M., Chaudrai, R., Bucknall, C. E., Mansur, A., & Patterson, C. C. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202678.070 · Cited by 2
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Authors: O'Neill, S., Sweeney, J., Patterson, C. C., Menzies-Gow, A., Niven, R., Mansur, A. H., Bucknall, C., Chaudhuri, R., Thomson, N. C., Brightling, C. E., O'Neill, C., Heaney, L. G., & on behalf of the British Thoracic Society Difficult Asthma Network
Affiliations: Queen's University Belfast (GB)
Royal Brompton Hospital (GB)
Manchester Academic Health Science Centre (GB)
Heartlands Hospital (GB)
Glasgow Royal Infirmary (GB)
Gartnavel General Hospital (GB)
University of Leicester (GB)
Corresponding author: Heaney, L. G.
ORCID: Patterson, C. C.
Menzies-Gow, A.
Niven, R.
Mansur, A. H.
Chaudhuri, R.
Thomson, N. C.
Brightling, C. E.
Heaney, L. G.
Venue: Thorax
Publisher: BMJ
Published: 2014-06-10
Volume: 70
Issue: 4
Pages: 376-378
ISSN: 0040-6376 (ISSN-L)
DOI: 10.1136/thoraxjnl-2013-204114
OpenAlex: W2171124311
Cited by: 186
References: 5
Citations by year: 2026: 7 · 2025: 9 · 2024: 6 · 2023: 18 · 2022: 18 · 2021: 19 · 2020: 24 · 2019: 23 · 2018: 24 · 2017: 18 · 2016: 11 · 2015: 7 · 2014: 2
FWCI: 8.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Thorax (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Funders: Wellcome Trust
National Institute for Health and Care Research (NF-SI-0512-10018)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: severe refractory asthma, health care costs, treatment costs, cost drivers, FEV1, oral corticosteroids, body mass index, location of care, National Health Service
MeSH terms: Adult, Asthma, Female, Forced Expiratory Volume, Glucocorticoids, United Kingdom, Health Services, Health Services Research, Humans, Male, Middle Aged, Registries, State Medicine, Body Mass Index, Drug Costs, Health Care Costs, Anti-Asthmatic Agents

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The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry

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