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Predictors of mortality in Middle East respiratory syndrome (MERS)
Open accessAbstract
We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5–10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11–16, p=0.07) during the course of disease, were associated with mortality.
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Cited by
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
Rogers, J. P., Chesney, E., Oliver, D., Pollak, T. A., McGuire, P., Fusar-Poli, P., Zandi, M. S., Lewis, G., & David, A. S. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30203-0 · Cited by 2,407
Du, R.-H., Liang, L.-R., Yang, C.-Q., Wang, W., Cao, T.-Z., Li, M., Guo, G.-Y., Du, J., Zheng, C.-L., Zhu, Q., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00524-2020 · Cited by 1,452
Wu, F., Wang, A., Liu, M., Wang, Q., Chen, J., Xia, S., Ling, Y., Zhang, Y., Xun, J., Lu, L., et al. (2020) · doi:10.1101/2020.03.30.20047365 · Cited by 754
Tian, J., Yuan, X., Xiao, J., Zhong, Q., Yang, C., Liu, B., Cai, Y., Lu, Z., Wang, J., Wang, Y., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30309-0 · Cited by 528
Metadata
- Authors
- Hong, K.-H., Choi, J.-P., Hong, S.-H., Lee, J., Kwon, J.-S., Kim, S.-M., Park, S. Y., Rhee, J.-Y., Kim, B.-N., Choi, H. J., Shin, E.-C., Pai, H., Park, S.-H., & Kim, S.-H.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2017-07-19
- Volume
- 73
- Issue
- 3
- Pages
- 286-289
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W2738334516
- Cited by
- 200
- References
- 0
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hong, K.-H., Choi, J.-P., Hong, S.-H., Lee, J., Kwon, J.-S., Kim, S.-M., Park, S. Y., Rhee, J.-Y., Kim, B.-N., Choi, H. J., Shin, E.-C., Pai, H., Park, S.-H., & Kim, S.-H. (2018). Predictors of mortality in Middle East respiratory syndrome (MERS). Thorax. https://doi.org/10.1136/thoraxjnl-2016-209313
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