Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study
Open accessAbstract
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201‒11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279‒4.747; p=0.007), CD3+CD8+T-cells ≤75 cells·μL−1(OR 3.982, 95% CI 1.761‒9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1(OR 4.077, 95% CI 1.778‒9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case–control study, CD3+CD8+T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia. We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.
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- Authors
- Du, R.-H., Liang, L.-R., Yang, C.-Q., Wang, W., Cao, T.-Z., Li, M., Guo, G.-Y., Du, J., Zheng, C.-L., Zhu, Q., Hu, M., Li, X.-Y., Peng, P., & Shi, H.-Z.
- Affiliations
- Wuhan Pulmonary Hospital (CN)
- Capital Medical University (CN)
- Corresponding author
- Shi, Huan-Zhong
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2020-04-08
- Volume
- 55
- Issue
- 5
- Pages
- 2000524
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- PMC
- PMC7144257
- OpenAlex
- W3015552915
- Cited by
- 1,452
- References
- 18
- Citations by year
- 2026: 8 · 2025: 26 · 2024: 78 · 2023: 112 · 2022: 236 · 2021: 495 · 2020: 495 · 2018: 1
- FWCI
- 43.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Respiratory Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- 1351 Talents Program of Beijing Chao-Yang Hospital, China (WXZXZ-2017-01)
- Beijing Municipal Administration of Hospitals (SML20150301)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pneumonia, SARS-CoV-2, mortality risk factors, CD3+CD8+ T cells, cardiac troponin I, cardiovascular comorbidity, cerebrovascular disease, elderly patients, prognostic factors, hospitalized patients, case-control study, prospective cohort
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Cerebrovascular Disorders, China, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Prospective Studies, Comorbidity, Case-Control Studies, Age Distribution, Coronavirus, Coronavirus Infections, CD8-Positive T-Lymphocytes, Troponin I, Pandemics
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