Cited by 209Glutathione Transferases and PolymorphismsAsthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) Research

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Glutathione S transferase deficiency and passive smoking increase childhood asthma

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Kabesch, M·2004·Thorax

DOI 10.1136/thx.2003.016667PMC PMC1747082

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Abstract

BACKGROUND: It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma. METHODS: A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GSTM1 and GSTT1 genotypes and asthma as well as atopy was investigated with respect to current and in utero ETS exposure. RESULTS: In children lacking the GSTM1 allele who were exposed to current ETS the risk for current asthma (OR 5.5, 95% CI 1.6 to 18.6) and asthma symptoms such as wheeze ever (OR 2.8, 95% CI 1.3 to 6.0), current wheezing (OR 4.7, 95% CI 1.8 to 12.6) and shortness of breath (OR 8.9, 95% CI 2.1 to 38.4) was higher than in GSTM1 positive individuals without ETS exposure. Hints of an interaction between ETS exposure and GSTM1 deficiency were identified. In utero smoke exposure in GSTT1 deficient children was associated with significant decrements in lung function compared with GSTT1 positive children not exposed to ETS. CONCLUSIONS: GSTM1 and GSTT1 deficiency may increase the adverse health effects of in utero and current smoke exposure.

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Authors: Kabesch, M.
Affiliations: Ludwig-Maximilians-Universität München (DE)
Corresponding author: Kabesch, M
ORCID: Kabesch, M
Venue: Thorax
Publisher: BMJ
Published: 2004-07-01
Volume: 59
Issue: 7
Pages: 569-573
ISSN: 0040-6376 (ISSN-L)
DOI: 10.1136/thx.2003.016667
PMC: PMC1747082
OpenAlex: W1981676959
Cited by: 209
References: 30
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 15
FWCI: 5.57
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Thorax (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: GSTM1, GSTT1, childhood asthma, passive smoking, environmental tobacco smoke, wheezing, atopy, lung function, gene-environment interaction, detoxification
MeSH terms: Asthma, Child, Cross-Sectional Studies, Female, Forced Expiratory Volume, Gene Frequency, Genotype, Glutathione Transferase, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Sounds, Risk Factors, Tobacco Smoke Pollution, Vital Capacity

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Glutathione S transferase deficiency and passive smoking increase childhood asthma

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