The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Glutathione S transferase deficiency and passive smoking increase childhood asthma
Open accessAbstract
BACKGROUND: It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma. METHODS: A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GSTM1 and GSTT1 genotypes and asthma as well as atopy was investigated with respect to current and in utero ETS exposure. RESULTS: In children lacking the GSTM1 allele who were exposed to current ETS the risk for current asthma (OR 5.5, 95% CI 1.6 to 18.6) and asthma symptoms such as wheeze ever (OR 2.8, 95% CI 1.3 to 6.0), current wheezing (OR 4.7, 95% CI 1.8 to 12.6) and shortness of breath (OR 8.9, 95% CI 2.1 to 38.4) was higher than in GSTM1 positive individuals without ETS exposure. Hints of an interaction between ETS exposure and GSTM1 deficiency were identified. In utero smoke exposure in GSTT1 deficient children was associated with significant decrements in lung function compared with GSTT1 positive children not exposed to ETS. CONCLUSIONS: GSTM1 and GSTT1 deficiency may increase the adverse health effects of in utero and current smoke exposure.
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“Subsequent research has demonstrated physiologic changes, including increased airway resistance and decreased lung function after in utero smoke exposure in children with GSTTI and GSTP1 alleles.86,88”
From Impact of Tobacco Smoke and Nicotine Exposure on Lung Development (2016) · cites this paper as [88]
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Cites
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A Randomized Trial of Adjuvant Chemotherapy with Uracil–Tegafur for Adenocarcinoma of the Lung
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Research works printed but not linked: 1
- [8]8. Kabesch, Hoefler, Carr, et al www.thoraxjnl.com on August 21, 2023 by guest. Protected by copyright. http://thorax.bmj.com/ Thorax: first published as 10.1136/thx.2003.016667 on 28 June 2004. Downloaded from
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British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023
Glutathione dysregulation and the etiology and progression of human diseases
Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · Biological Chemistry · doi:10.1515/bc.2009.033 · Cited by 1,145
Discovering susceptibility genes for asthma and allergy
Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635
Strzelak, A., Ratajczak, A., Adamiec, A., & Feleszko, W. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15051033 · Cited by 557
Prenatal Tobacco Smoke Exposure Affects Global and Gene-specific DNA Methylation
Breton, C. V., Byun, H., Wenten, M., Pan, F., Yang, A. S., & Gilliland, F. D. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0135oc · Cited by 591
Metadata
- Authors
- Kabesch, M.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Kabesch, M
- ORCID
- Kabesch, M
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2004-07-01
- Volume
- 59
- Issue
- 7
- Pages
- 569-573
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC1747082
- OpenAlex
- W1981676959
- Cited by
- 209
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 15
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- GSTM1, GSTT1, childhood asthma, passive smoking, environmental tobacco smoke, wheezing, atopy, lung function, gene-environment interaction, detoxification
- MeSH terms
- Asthma, Child, Cross-Sectional Studies, Female, Forced Expiratory Volume, Gene Frequency, Genotype, Glutathione Transferase, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Sounds, Risk Factors, Tobacco Smoke Pollution, Vital Capacity
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