The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
COPD exacerbations {middle dot} 2: Aetiology
Open accessAbstract
Exacerbations of COPD are thought to be caused by complex interactions between the host, bacteria, viruses, and environmental pollution. These factors increase the inflammatory burden in the lower airways, overwhelming the protective anti-inflammatory defences leading to tissue damage. Frequent exacerbations are associated with increased morbidity and mortality, a faster decline in lung function, and poorer health status, so prevention or optimal treatment of exacerbations is a global priority. In order to evolve new treatment strategies there has been great interest in the aetiology and pathophysiology of exacerbations, but progress has been hindered by the heterogeneous nature of these episodes, vague definitions of an exacerbation, and poor stratification of known confounding factors when interpreting results. We review how an exacerbation should be defined, its inflammatory basis, and the importance of exacerbations on disease progression. Important aetiologies, with their potential underlying mechanisms, are discussed and the significance of each aetiology is considered.
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An association between air pollution and mortality in six U.S. cities
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Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
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Antibiotic Therapy in Exacerbations of Chronic Obstructive Pulmonary Disease
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Effect of Exacerbation on Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
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Influenza-Associated Hospitalizations in the United States
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Time Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
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Cited by
COPD exacerbations: Defining their cause and prevention
Wedzicha, J. A., & Seemungal, T. A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61382-8 · Cited by 1,370
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Benam, K. H., Novak, R., Nawroth, J., Hirano-Kobayashi, M., Ferrante, T. C., Choe, Y., Prantil-Baun, R., Weaver, J. C., Bahinski, A., Parker, K. K., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.10.003 · Cited by 309
Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Bozinovski, S., Hutchinson, A., Thompson, M., MacGregor, L., Black, J., Giannakis, E., Karlsson, A.-S., Silvestrini, R., Smallwood, D., Vlahos, R., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200705-678oc · Cited by 260
Miller, G., & Chen, E. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068fcf9 · Cited by 159
Metadata
- Authors
- Sapey, E.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2006-03-01
- Volume
- 61
- Issue
- 3
- Pages
- 250-258
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2131829840
- Cited by
- 437
- References
- 122
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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