CoChat
Sign Up
Cited by 122Muscle Physiology and DisordersChronic Obstructive Pulmonary Disease (COPD) ResearchExercise and Physiological Responses

Effects of rehabilitative exercise on peripheral muscle TNF , IL-6, IGF-I and MyoD expression in patients with COPD

Open access
Vogiatzis, I., Stratakos, G., Simoes, D. C M, Terzis, G., Georgiadou, O., Roussos, C., Zakynthinos, S.·2007·Thorax
DOI 10.1136/thx.2006.069310PMC PMC2117139
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation. This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning. METHODS: Fifteen patients with COPD (mean (SE) forced expiratory volume in 1 s 36 (4)% predicted) undertook high-intensity exercise training 3 days/week for 10 weeks. Before and after the training programme the concentration of tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma was determined by ELISA, and vastus lateralis mRNA expression of TNFalpha, IL-6, total insulin-like growth factor-I (IGF-I) and its isoform mechanogrowth factor (MGF) and myogenic differentiation factor D (MyoD) were assessed by real-time PCR. Protein levels of TNFalpha, IGF-I and MyoD were measured by Western blotting. RESULTS: Rehabilitation improved peak exercise work rate by 10 (2%) (p = 0.004) and mean fibre cross-sectional area from 4061 (254) microm(2) to 4581 (241) microm(2) (p = 0.001). Plasma inflammatory mediators and vastus lateralis expression of TNFalpha and IL-6 were not significantly modified by training. In contrast, there was a significant increase in mRNA expression of IGF-I (by 67 (22)%; p = 0.044), MGF (by 67 (15)%; p = 0.002) and MyoD (by 116 (30)%; p = 0.001). The increase observed at the mRNA level was also seen at the protein level for IGF-I (by 72 (36)%; p = 0.046) and MyoD (by 67 (21)%; p = 0.012). CONCLUSIONS: Pulmonary rehabilitation can induce peripheral muscle adaptations and modifications in factors regulating skeletal muscle hypertrophy and regeneration without decreasing the levels of systemic or local muscle inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/thx.2006.069310

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Inflammation is not the sole driver of COPD muscle atrophy, as exercise can affect factors regulating muscle hypertrophy and regeneration without affecting levels of systemic or local muscle inflammation.

    “However, inflammation is not the sole driver as exercise can affect factors regulating muscle hypertrophy and regeneration without affecting the levels of systemic or local muscle inflammation [19].”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [19]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 35

  1. Agustı ´AGN. Systemic effects of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005;2:367-70.
  2. Broekhuizen R, Wouters EFM, Creutzberg EC, et al. Elevated CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2005;61:17-22.
  3. Gosker HR, Wouters EFM, van der Vusse GJ, et al. Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives. Am J Clin Nutr 2000;71:1033-47.
  4. Couillard A, Prefaut C. From muscle disuse to myopathy in COPD: potential contribution of oxidative stress. Eur Respir J 2005;26:703-19.
  5. Rabinovich RA, Figueras M, Ardite E, et al. Increased tumor necrosis factor-a plasma levels during moderate-intensity exercise in COPD patients. Eur Respir J 2003;21:789-94.
  6. Montes de Oca M, Torres SH, De Sanctis J, et al. Skeletal muscle inflammation and nitric oxide in patients with COPD. Eur Respir J 2005;26:390-7.
  7. Koechlin C, Maltais F, Saey D, et al. Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease. Thorax 2005;60:834-41.
  8. Broussard SR, McCusker R, Novakofski JE, et al. Cytokine-hormone interactions: tumor necrosis factor-a impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology 2003;144:2988-96.
  9. Debigare R, Cote CH, Maltais F. Peripheral muscle wasting in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164:1712-7.
  10. Whittom F, Jobin J, Simard PM, et al. Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Med Sci Sports Exerc 1998;30:1467-74.
  11. Vogiatzis I, Terzis G, Nanas S, et al. Skeletal muscle adaptations to interval training in patients with advanced COPD. Chest 2005;128:3838-45.
  12. Bolton CE, Broekhuizen R, Ionescu AA, et al. Cellular protein breakdown and systemic inflammation are unaffected by pulmonary rehabilitation in COPD. Thorax 2006;62:109-14.
  13. Hameed M, Lange KHW, Andersen JL, et al. The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. J Physiol 2003;555:231-40.
  14. Kosek DJ, Kim J, Petrella JK, et al. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol 2006;101:531-44.
  15. Singh MA, Ding W, Manfredi TJ, et al. Insulin-like growth factor-I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol 1999;277:E135-43.
  16. Kostek MC, Delmonico MJ, Reichel JB, et al. Muscle strength response to strength training is influenced by insulin-like growth factor-I genotype in older adults. J Appl Physiol 2005;98:2147-54.
  17. Hambrecht R, Schulze PC, Gielen S, et al. Effects of exercise training on insulin- like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure. Eur J Card Prev Rehab 2005;12:401-6.
  18. Pauwels RA, Buist AS, Caverley PM, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/ WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med 2001;163:1256-76.
  19. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-81.
  20. Vogiatzis I, Nanas S, Kastanakis E, et al. Dynamic hyperinflation and tolerance to interval exercise in patients with advanced COPD. Eur Respir J 2004;24:358-63.
  21. Vogiatzis I, Nanas S, Roussos C. Interval training as an alternative modality to continuous exercise in patients with COPD. Eur Respir J 2002;20:12-9.
  22. Psilander N, Damsgaard R, Pilegaard H. Resistance exercise alters MRF and IGF- I mRNA content in human skeletal muscle. J Appl Physiol 2003;95:1038-44.
  23. Brooke M, Kaiser K. Muscle fiber types. How many and what kind? Arch Neurol 1970;23:369-79.
  24. Papapetropulos A, Simoes DCM, Xanthou G, et al. Soluble guanylyl cyclase expression is reduced in allergic asthma. Am J Physiol 2005;277:E135-43.
  25. Jemiolo B, Trappe S. Single muscle fiber gene expression in human skeletal muscle: validation of internal control with exercise. Biochem Biophys Res Commun 2004;320:1043-50.
  26. Barreiro E, Gea J, Corominas JM, et al. Nitric oxide synthaseand protein oxidation in the quadriceps femoris of patientswith chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2003;29:771-8.
  27. Koechlin C, Couillard A, Cristol JP, et al. Does systemic inflammation trigger local exercise-induced oxidative stress in COPD? Eur Respir J 2004;23:538-44.
  28. Debigare R, Marquis K, Cote CH, et al. Catabolic/anabolic balance and muscle wasting in patients with COPD. Chest 2003;124:83-9.
  29. Rabinovich RA, Ardide E, Troosters T, et al. Reduced muscle redox capacity after endurance training in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164:1114-8.
  30. Mercken EM, Hageman GJ, Schols AMWJ, et al. Rehabilitation decrease exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;164:994-1001.
  31. Li YP, Schwartz RJ, Waddell ID, et al. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kB activation in response to tumor necrosis factor alpha. FASEB J 1998;12:871-80.
  32. Costelli P, Muscaritoli M, Bossola M, et al. Skeletal muscle wasting on tumor- bearing rats is associated with MyoD down-regulation. Int J Oncol 2005;26:1663-8.
  33. Charge SB, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev 2004;84:209-38.
  34. Moore MJ. From birth to death: the complex lives of eukaryotic mRNAs. Science 2005;309:1514-8.
  35. Ferrier KE, Nestel P, Taylor A, et al. Diet but not aerobic exercise training reduces skeletal muscle TNF-a in overweight humans. Diabetologia 2004;47:630-7.

Cited by

Sorted by citations

Authors
Vogiatzis, I., Stratakos, G., Simoes, D. C. M., Terzis, G., Georgiadou, O., Roussos, C., & Zakynthinos, S.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Vogiatzis, I.
ORCID
Venue
Thorax
Publisher
BMJ
Published
2007-05-25
Volume
62
Issue
11
Pages
950-956
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.2006.069310
PMC
PMC2117139
OpenAlex
W2023201233
Cited by
122
References
5
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 3 · 2014: 14 · 2013: 8 · 2012: 10
FWCI
3.58
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Northumbria Research Link (Northumbria University) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Pfizer
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
chronic obstructive pulmonary disease, pulmonary rehabilitation, high-intensity training, skeletal muscle atrophy, muscle inflammation, TNF-α, interleukin-6, insulin-like growth factor I, MyoD, vastus lateralis, muscle hypertrophy, muscle regeneration, systemic inflammation, C-reactive protein
MeSH terms
Aged, Exercise Therapy, Female, Forced Expiratory Volume, Humans, Insulin-Like Growth Factor I, Male, RNA, Messenger, Tumor Necrosis Factor-alpha, Vital Capacity, Interleukin-6, MyoD Protein, Muscle, Skeletal, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review