IL-7 is expressed and secreted by human skeletal muscle cells
Abstract
In addition to generating movement, skeletal muscle may have a function as a secretory organ. The aim of the present study was to identify novel proteins with signaling capabilities secreted from skeletal muscle cells. IL-7 was detected in media conditioned by primary cultures of human myotubes differentiated from satellite cells, and concentrations increased with incubation time. By immunoblotting and real-time RT-PCR IL-7 expression was confirmed at both protein and mRNA levels. Furthermore, with immunofluorescence and specific antisera, multinucleated myotubes were found to coexpress IL-7 and myosin heavy chain. During differentiation of human myotubes from satellite cells, IL-7 expression increased at mRNA and protein levels. In contrast, mRNA expression of the IL-7 receptor was 80% lower in myotubes compared with satellite cells. Incubations with recombinant IL-7 under differentiation conditions caused approximately 35% reduction in mRNA for the terminal myogenic markers myosin heavy chain 2 (MYH2) and myogenin (MYOG), suggesting that IL-7 may act on satellite cells to inhibit development of the muscle fiber phenotype. Alternative routes of cell development were investigated, and IL-7 increased migration of satellite cells by 40% after 48 h in a Transwell system, whereas cell proliferation remained unchanged. In vivo, real-time RT-PCR analysis of musculus vastus lateralis (n = 10) and musculus trapezius (n = 7) biopsies taken from male individuals undergoing a strength training program demonstrated that after 11 wk mean IL-7 mRNA increased by threefold (P = 0.01) and fourfold (P = 0.04), respectively. In conclusion, we have demonstrated that IL-7 is a novel myokine regulated both in vitro and in vivo, and it may play a role in the regulation of muscle cell development.
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IL-15 and IL-7 possess anabolic features in rodent models.
“A number of other myokines, including IL‑15 (53) and IL-7 (54) have further been demonstrated to possess anabolic features in rodent models.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [54]
Skeletal muscle secretes IL-7.
“A post-exercise surge in thymopoiesis is possible considering that skeletal muscle secretes IL-7 (Haugen et al. 2010) which might in turn increase thymic mass and lead to the emergence of recent thymic emigrants (Fry and Mackall 2005).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Haugen et al. 2010
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“IL-7 [61] and IL-15 [62] are myokines that might stimulate lymphocyte proliferation, and it has been suggested that IL-7 exerts protective effects on the thymus.”
BackgroundForterre, A. V., Jalabert, A., Chikh, K., Pesenti, S., Euthine, V., Granjon, A., Errazuriz, E., Lefai, É., Vidal, H., & Rome, S. (2013) · Cell Cycle · doi:10.4161/cc.26808 · Cited by 191 · see citing works
“, IL-4, IL-7, and IL-13).(27,28) Recently, it has been demonstrated that muscle cells secrete nanoparticles with exosomal properties.”
BackgroundCrosstalk between adipokines and myokines in fat browning
Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works
Raschke, S., Eckardt, K., Bjørklund Holven, K., Jensen, J., & Eckel, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062008 · Cited by 199 · see citing works
“Several myokines are described in the literature to be regulated by contraction, like angiopoietin-related protein 4 [5], fibroblast growth factor 21 [6], interleukin (IL)-6 [7,8], IL-7 [9], IL-15 [10], leukemia inhibitory factor [11], myonectin [12], myostatin [13] and vascular endothelial growth factor [14,15].”
BackgroundSarcopenia – The search for emerging biomarkers
Kalinkovich, A., & Livshits, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.05.001 · Cited by 187 · see citing works
“Indeed, to mention just a few, such molecules as IL-7 & IL-15 (Haugen et al., 2010; Quinn et al., 2002), apelin (Besse-Patin et al., 2014), caveolin-3 (Hadj Sassi et al., 2012), follistatin-like protein 1 (FSTL1) (Görgens et al., 2013), perilipins 2 and 5 (Conte et al., 2015), and adiponectin (Liu…”
Norheim, F., Raastad, T., Thiede, B., Rustan, A. C., Drevon, C. A., & Haugen, F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00326.2011 · Cited by 180 · see citing works
“Myoblasts were differentiated to myotubes (19) and rinsed with PBS 6 times prior to incubation for 6 h in 9 ml serum-free DMEM (containing 25 mmol/l glucose and 25 pmol/l insulin) per 175 cm(2) cell-bind flask (cat.”
InfluentialAerobic fitness is associated with lower proportions of senescent blood T-cells in man
Spielmann, G., McFarlin, B. K., O’Connor, D. P., Smith, P. J. W., Pircher, H., & Simpson, R. J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.226 · Cited by 180 · see citing works
Forterre, A. V., Jalabert, A., Berger, E., Baudet, M., Chikh, K., Errazuriz-Cerda, E., Larichaudy, J. D., Chanon, S., Weiss‐Gayet, M., Hesse, A.-M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084153 · Cited by 176 · see citing works
Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 181 · see citing works
Exercise and regulation of adipokine and myokine production
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Self-citationMyokines mediate the cross talk between skeletal muscle and other organs
Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162 · see citing works
Skeletal muscle regeneration and impact of aging and nutrition
Domingues-Faria, C., Vasson, M.-P., Goncalves-Mendes, N., Boirie, Y., & Walrand, S. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.004 · Cited by 157 · see citing works
Exercise and the immune system: taking steps to improve responses to cancer immunotherapy
Gustafson, M. P., Wheatley, C. M., Rosenthal, A. C., Gastineau, D. A., Katsanis, E., Johnson, B. D., & Simpson, R. J. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001872 · Cited by 155 · see citing works
Muscle-bone interactions: From experimental models to the clinic? A critical update
Laurent, M. R., Dubois, V., Claessens, F., Verschueren, S., Vanderschueren, D., Gielen, E., & Jardí, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.017 · Cited by 152 · see citing works
“IL-7 is another myokine (Haugen et al., 2010) with a known double-edged role in osteoclastogenesis and bone formation”
The effect of physical exercise on anticancer immunity
Fiuza‐Luces, C., Valenzuela, P. L., Gálvez, B. G., Ramírez, M. R., López‐Soto, A., Simpson, R. J., & Lucía, A. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00943-0 · Cited by 154 · see citing works
The skeletal muscle secretome: an emerging player in muscle–bone crosstalk
Hamrick, M. W. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.60 · Cited by 145 · see citing works
The search for exercise factors in humans
Catoire, M., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-263699 · Cited by 137 · see citing works
“This approach has been pursued for angiopoietin-like 4 (ANGPTL4) (23), IL-7 (24), Apelin (25), irisin (16), and secreted protein acidic and rich in cysteine (SPARC) (26).”
BackgroundInfluentialCaprara, G. (2021) · Nutrients · doi:10.3390/nu13020429 · Cited by 143 · see citing works
Systemic Nutrient and Stress Signaling via Myokines and Myometabolites
Rai, M., & Demontis, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105305 · Cited by 123 · see citing works
Implications of exercise-induced adipo-myokines in bone metabolism
Lombardi, G., Sanchis‐Gomar, F., Perego, S., Sansoni, V., & Banfi, G. (2015) · Endocrine · doi:10.1007/s12020-015-0834-0 · Cited by 117 · see citing works
Immune system and sarcopenia: Presented relationship and future perspective
Zhang, X., Li, H., He, M., Wang, J., Wu, Y., & Li, Y. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111823 · Cited by 112 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
Yue, Y., He, Z., Zhou, Y., Ross, R. P., Stanton, C., Zhao, J., Zhang, H., Yang, B. K., & Chen, W. (2020) · Food & Function · doi:10.1039/d0fo02670k · Cited by 107 · see citing works
Guo, B., Zhang, Z.-K., Liang, C., Li, J., Liu, J., Lu, A., Zhang, B.-T., & Zhang, G. (2017) · Calcified Tissue International · doi:10.1007/s00223-016-0209-4 · Cited by 96 · see citing works
“identified IL-7 as another myokine, which can be detected in the media of primary cultures of human myotubes differentiated from satellite cells and increased with the incubation time [47].”
BackgroundGlobal mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines
Pourteymour, S., Eckardt, K., Holen, T., Langleite, T. M., Lee-Ødegård, S., Jensen, J., Birkeland, K. I., Drevon, C. A., & Hjorth, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.007 · Cited by 99 · see citing works
“vastus lateralis from three male donors (age 33e62 y) were used to isolate primary human satellite cells [31].”
MethodExosomes and Extracellular RNA in Muscle and Bone Aging and Crosstalk
Qin, W., & Dallas, S. L. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00537-7 · Cited by 93 · see citing works
How does the skeletal muscle communicate with the brain in health and disease?
Isaac, A. R., Lima‐Filho, R. A. S., & Lourenco, M. V. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108744 · Cited by 95 · see citing works
Prebiotics as functional food ingredients preventing diet-related diseases
Florowska, A., Krygier, K., Florowski, T., & Dłużewska, E. (2016) · Food & Function · doi:10.1039/c5fo01459j · Cited by 92 · see citing works
Aging and immunity – Impact of behavioral intervention
Müller, L., & Pawelec, G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.11.015 · Cited by 93 · see citing works
“Interleukin-7, which is known to play a crucial role in homeostasis of naïve T cells, has been shown to be released from active skeletal muscles (Haugen et al., 2010), possibly contributing to increased thymopoiesis and exercise-induced immune enhancement (Simpson et al.”
Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
Arias, M., Ranchal, I., Romero‐Gómez, M., & Crespo, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223163 · Cited by 87 · see citing works
“A large list of molecules have been recently considered as myokines, like angiopoietin-like 4 (ANGPTL4) [22], fibroblast growth factor-21 (FGF21) [23], interleukin-6 (IL-6) [24], IL-7 [25], IL-8, IL-15 [26], leukemia inhibitory factor (LIF) [27], myonectin [28], myostatin [29], vascular endothelial growth factor (VEGF…”
BackgroundHjorth, M., Pourteymour, S., Görgens, S. W., Langleite, T. M., Lee, S., Holen, T., Gulseth, H. L., Birkeland, K. I., Jensen, J., Drevon, C. A., et al. (2016) · Acta Physiologica · doi:10.1111/apha.12631 · Cited by 83 · see citing works
“vastus lateralis of 5 male donors (33–53 years of age) were isolated (Haugen et al. 2010).”
BackgroundMolecular Nutrition Research—The Modern Way Of Performing Nutritional Science
Norheim, F., Gjelstad, I., Hjorth, M., Vinknes, K., Langleite, T., Holen, T., Jensen, J., Dalen, K., Karlsen, A., Kielland, A., et al. (2012) · Nutrients · doi:10.3390/nu4121898 · Cited by 83 · see citing works
“(2010) [193] described IL-7 as a novel myokine, which may play a role in the regulation”
BackgroundMolecular insights of exercise therapy in disease prevention and treatment
Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 89 · see citing works
Lombardi, G., Ziemann, E., & Banfi, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00060 · Cited by 88 · see citing works
“IL-7 is essential for T-cell and B-cell development (136) but it is also expressed by the contracting muscles where it acts paracrinally to induce migration in satellite cells (158).”
BackgroundThe Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84 · see citing works
Silva, L. C. R., de Araújo, A. L., Fernandes, J. R., Matias, M. D. S. T., da Silva, P. R., Duarte, A. J. S., Leme, L. E. G., & Benard, G. (2016) · AGE · doi:10.1007/s11357-016-9879-0 · Cited by 82 · see citing works
Myonectin deletion promotes adipose fat storage and reduces liver steatosis
Little, H. C., Rodriguez, S., Lei, X., Tan, S. Y., Stewart, A. N., Sahagun, A., Sarver, D. C., & William Wong, G. (2019) · The FASEB Journal · doi:10.1096/fj.201900520r · Cited by 78 · see citing works
“Of the hundreds of proteins secreted by skeletal muscle (7–9), only a few have been functionally characterized, includingmyostatin (10–12), IL-6 (13), fibroblast growth factor 21 (14, 15), insulin-like 6 (16), follistatinlike 1 (17), leukemia inhibitory factor (18), IL-7 (19), IL-15 (20), musclin (21, 22), and irisin…”
BackgroundPhysical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?
Fernández‐Lázaro, D., González-Bernal, J. J., Sánchez-Serrano, N., Navascués, L. J., Ascaso, A., & Mielgo‐Ayuso, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228496 · Cited by 75 · see citing works
“In this sense, by immunoblotting and real-time reverse transcription polymerase chain reaction (RT-PCR), the IL-7 expression was confirmed with both protein and mRNA increased levels by regular moderate Ex [50], which could stimulate thymus function when IL-7 increases in plasma.”
BackgroundMicrophysiological Analysis Platform of Pancreatic Islet β‐Cell Spheroids
Lee, S. H., Hong, S., Song, J., Cho, B., Han, E. J., Kondapavulur, S., Kim, D., & Lee, L. P. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201701111 · Cited by 74 · see citing works
Gu, S., Zhao, L., Wu, Y., Li, S., Sun, J., Huang, J., & Li, D. (2015) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-015-1838-x · Cited by 74 · see citing works
Differential Bone Loss in Mouse Models of Colon Cancer Cachexia
Bonetto, A., Kays, J. K., Parker, V. A., Matthews, R. R., Barreto, R., Puppa, M., Kang, K. S., Carson, J. A., Guise, T. A., Mohammad, K. S., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2016.00679 · Cited by 73 · see citing works
“…cytokines, such as IL-6, IL7, and IL-15, were originally described in association with muscle contraction and exercise, thus further supporting the idea that mechanical stimulation is fundamental to maintain bone integrity (Nielsen et al., 2007; Pedersen, 2009; Haugen et al., 2010; Hamrick, 2012).”
BackgroundMuscle cell‐derived cytokines in skeletal muscle regeneration
Waldemer, R. J., Kim, D., & Chen, J. (2022) · FEBS Journal · doi:10.1111/febs.16372 · Cited by 74 · see citing works
Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines
Seldin, M. M., & Wong, G. W. (2012) · Adipocyte · doi:10.4161/adip.20877 · Cited by 70 · see citing works
Identification of Differentially Regulated Secretome Components During Skeletal Myogenesis
Chan, C. Y. X., Masui, O., Krakovska, O., Belozerov, V. E., Voisin, S. N., Ghanny, S., Chen, J., Dharsee, M., Zhu, P., Evans, K., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004804 · Cited by 69 · see citing works
“Apart from the well-known myokines, such as members of the insulin-like growth factor-1 (54–63) and transforming growth factor (TGF) families (64– 72), there are studies investigating other myokines, such as plasminogen activator (73), collagenase (74), decorin (75), glial growth factor (76), neurocrescin (77), meltri…”
BackgroundKim, M. H., Kay, D. I., Rudra, R. T., Chen, B. M., Hsu, N., Izumiya, Y., Martinez, L., Spencer, M. J., Walsh, K., Grinnell, A. D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr015 · Cited by 66 · see citing works
“It is feasible that myokine production downstream of Akt indirectly promotes satellite cell differentiation through paracrine signaling from mature myofibers (64) and autocrine amplification of IGF-1 receptor stimulation from differentiating myoblasts (61).”
BackgroundTurner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 65 · see citing works
“Finally, contracting skeletal muscle secretes IL-7 [67] which might increase thymic mass and promote the emergence of recent thymic emigrants [68].”
BackgroundHjorth, M., Norheim, F., Meen, A. J., Pourteymour, S., Lee-Ødegård, S., Holen, T., Jensen, J., Birkeland, K. I., Martinov, V. N., Langleite, T. M., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12473 · Cited by 65 · see citing works
“vastus lateralis of five healthy, male donors (33–53 years of age) were isolated as previously described (Haugen et al. 2010).”
MethodPerilipin 4 in human skeletal muscle: localization and effect of physical activity
Pourteymour, S., Lee-Ødegård, S., Langleite, T. M., Eckardt, K., Hjorth, M., Bindesbøll, C., Dalen, K. T., Birkeland, K. I., Drevon, C. A., Holen, T., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12481 · Cited by 62 · see citing works
“3 software (Applied Biosystems) as previously described (Haugen et al. 2010).”
MethodInfluentialPedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00522.x · Cited by 59 · see citing works
Weigert, C., Lehmann, R., Hartwig, S., & Lehr, S. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300094 · Cited by 57 · see citing works
The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models
Maleiner, B., Tomasch, J., Heher, P., Oliver Spadiut, A., Rünzler, D., & Fuchs, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01130 · Cited by 56 · see citing works
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P. A., Pletz, M. W., Wagner, H., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301619r · Cited by 68 · see citing works
“Literature was searched to examine the acute changes in circulating levels of immunoregulatory myokines (i.e., IL-6, IL-10, IL-1ra, TNF-α , IL-15, IL-7, TGF-β 1, and FKN) induced by a bout of resistance exercise.”
BackgroundInfluentialMyokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance
Yi, J., Chen, J., Yao, X., Zhao, Z., Niu, X., Li, X., Sun, J., Ji, Y., Shang, T., Gong, L., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117326 · Cited by 59 · see citing works
Regulation of angiopoietin-like protein 4 production during and after exercise
Norheim, F., Hjorth, M., Langleite, T. M., Lee, S., Holen, T., Bindesbøll, C., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Kielland, A., et al. (2014) · Physiological Reports · doi:10.14814/phy2.12109 · Cited by 53 · see citing works
“Using High-Capacity cDNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA), 1000 ng of total RNA from human and mouse tissue samples or cells was converted into cDNA.”
BackgroundMethodInfluentialHanssen, K. E., Kvamme, N. H., Nilsen, T. S., Rønnestad, B. R., Ambjørnsen, I. K., Norheim, F., Kadi, F., Hallén, J., Drevon, C. A., & Raastad, T. (2012) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2012.01452.x · Cited by 51 · see citing works
“Other analyses of growth factors and myostatin in 10 selected subjects are as follows: Further analyses were either performed in 96-well plates (MGF) or with a custom-made 384-well microfluid card containing 96 predeveloped assays (Haugen et al., 2010).”
MethodBone-muscle crosstalk under physiological and pathological conditions
Dong, Y., Yuan, H., Ma, G., & Cao, H. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05331-y · Cited by 52 · see citing works
“IL7 signal has the potential to sustain the phenotype of SCs, which is evident in its ability to facilitate cellular migration and the expression of PAX7 , a marker of SCs that prevents myogenesis [67].”
BackgroundRoca-Rivada, A., Al–Massadi, O., Castelao, C., Senín, L. L., Alonso, J., Seoane, L. M., García‐Caballero, T., Casanueva, F. F., & Pardo, M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.06.037 · Cited by 48 · see citing works
Renin–angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms
Yosypiv, I. V. (2011) · Pediatric Nephrology · doi:10.1007/s00467-011-1820-2 · Cited by 46 · see citing works
Emery, A., Moore, S. E., Turner, J. E., & Campbell, J. P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.788113 · Cited by 44 · see citing works
“An important series of studies have shown that physically active individuals exhibit higher concentrations of immunoregulatory cytokines, such as interleukin (IL)-7 and IL-15 in blood (109, 127), which may be due to increased homeostatic cytokine output from skeletal muscle (102, 108) as both IL-15 and IL-7 are expres…”
BackgroundKoivisto, A., Olsén, T., Paur, I., Paulsen, G., Bastani, N. E., Garthe, I., Raastad, T., Matthews, J. B., Blomhoff, R., & Bøhn, S. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217895 · Cited by 47 · see citing works
Skeletal Muscle Protein Tyrosine Phosphatase 1B Regulates Insulin Sensitivity in African Americans
Stull, A. J., Wang, Z. Q., Zhang, X. H., Yu, Y., Johnson, W. D., & Cefalu, W. T. (2012) · Diabetes · doi:10.2337/db11-0744 · Cited by 44 · see citing works
“RPLP0 gene encodes the human acidic ribosomal phosphoprotein large P0 subunit and is used as a special housekeeping gene for human skeletal muscle (31,32).”
BackgroundPathophysiological mechanism of acute bone loss after fracture
Zheng, X.-Q., Huang, J., Lin, J., & Song, C. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.08.019 · Cited by 43 · see citing works
Myokines and Microbiota: New Perspectives in the Endocrine Muscle–Gut Axis
Saponaro, F., Bertolini, A., Baragatti, R., Galfo, L., Chiellini, G., Saba, A., & D’Urso, G. (2024) · Nutrients · doi:10.3390/nu16234032 · Cited by 43 · see citing works
Zamboni, M. M., Mazzali, G., Brunelli, A., Saatchi, T., Urbani, S., Giani, A., Rossi, A. P., Zoico, E., & Fantin, F. (2022) · Cells · doi:10.3390/cells11213361 · Cited by 42 · see citing works
“Furthermore, IL-7 plays an essential role in myogenesis and may influence the differentiation of satellite cells into fully developed skeletal muscle cells [58].”
BackgroundCornish, S. M., Bugera, E. M., Duhamel, T. A., Peeler, J. D., & Anderson, J. E. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04337-1 · Cited by 43 · see citing works
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 43 · see citing works
Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation
Covington, J. D., Tam, C. S., Bajpeyi, S., Galgani, J. E., Noland, R. C., Smith, S. R., Redman, L. M., & Ravussin, É. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000787 · Cited by 38 · see citing works
“IL-15 and leukocyte-inducing factor (LIF) have been speculated to regulate muscle cell growth and satellite cell proliferation (7,18), with IL-15 playing a potential role in adipose tissue lipolysis (33).”
Xu, J., Tang, M., Wu, X., Kong, X., Liu, Y., & Xu, X. (2022) · Food & Function · doi:10.1039/d1fo03804d · Cited by 38 · see citing works
- Authors
- Haugen, F., Norheim, F., Lian, H., Wensaas, A. J., Dueland, S., Berg, O., Funderud, A., Skålhegg, B. S., Raastad, T., & Drevon, C. A.
- Affiliations
- University of Oslo (NO)
- Norwegian School of Sport Sciences (NO)
- Corresponding author
- Haugen, Fred
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2010-04
- Volume
- 298
- Issue
- 4
- Pages
- C807-C816
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2112164340
- Cited by
- 237
- References
- 50
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 24 · 2023: 14 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 18 · 2015: 18 · 2014: 8 · 2013: 15 · 2012: 18
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- IL-7, myokines, skeletal muscle, satellite cells, myotubes, myogenesis, IL-7 receptor, myosin heavy chain, myogenin, resistance training, vastus lateralis, trapezius, muscle fiber phenotype
- MeSH terms
- Adult, Cell Differentiation, Cells, Cultured, Culture Media, Humans, Male, Middle Aged, RNA, Messenger, Biomarkers, Interleukin-7, Muscle Fibers, Skeletal, Myosin Heavy Chains, Receptors, Interleukin-7, Muscle Development, Satellite Cells, Skeletal Muscle, Cell Proliferation, Resistance Training
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