The DOI matches its Crossref record.
Effect of lung function and mode of inhalation on penetration of aerosol into the human lung.
Open accessAbstract
The method using radioactive tracer particles has been applied to study the effect of the mode of inhalation of aerosols on the depth of deposition in the lungs of 50 patients with airways obstruction. The findings show that the penetration of particles is directly related to: (1) volume inspired per breath (VI); (2) forced expiratory volume in one second (FEV1); and inversely related to (3) flow rate during inhalation (V). In mathematical terms, alveolar deposition (%) = 40-3 (VI)+10-98 (FEV1)--0-75 (V)+40-4; for this regression F = 4-41 and P less than 0-01.
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Citations
Cited by
Deposition, retention, and clearance of inhaled particles.
Lippmann, M., Yeates, D. B., & Albert, R. E. (1980) · Occupational and Environmental Medicine · doi:10.1136/oem.37.4.337 · Cited by 557
Labiris, N. R., & Dolovich, M. B. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01893.x · Cited by 451
Aerosol deposition considerations in inhalation therapy
Newman, S. P. (1985) · Chest · doi:10.1378/chest.88.2.152s · Cited by 264
Metadata
- Authors
- Pavia, D., Thomson, M. L., Clarke, S. W., & Shannon, H. S.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1977-04-01
- Volume
- 32
- Issue
- 2
- Pages
- 194-197
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2102244429
- Cited by
- 209
- References
- 0
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. https://app.cochat.ai/papers/10.1136/thx.32.2.194
- The paper
- Pavia, D., Thomson, M. L., Clarke, S. W., & Shannon, H. S. (1977). Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. Thorax. https://doi.org/10.1136/thx.32.2.194
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
