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Cited by 102Elasticity and Material ModelingCardiovascular Health and Disease PreventionPulmonary Hypertension Research and Treatments

Structural basis for the changing physical properties of human pulmonary vessels with age.

Open access
Mackay, E H, Banks, J, Sykes, B, Lee, G·1978·Thorax
DOI 10.1136/thx.33.3.335PMC PMC470893
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Abstract

Circumferential strips of pulmonary vessel wall were obtained at necropsy from the major arterial and venous branches at the lung hilum in patients aged 7-87 years. The extensibility of these strips was measured using the tension balance method of Harris et al. (British Heart Journal, 1965, 27, 651-659). The vessels were then bisected, and half of each strip was submitted for structural analysis using morphometric methods on paraffin sections stained to show the collagen, elastin, and muscle content. The other halves of the formalin-fixed vessel strips were examined chemically to determine their collagen content by estimation of the total hydroxyproline content. The thickness of the vessel media was measured microscopically on all of the sections examined. Quantitative measurements were made on 42 arteries and 37 veins. Contrary to expectation, there was a steady fall in medial collagen content with increasing age in arteries and veins. The decrease in collagen content was similar in the morphometric and chemical studies and was statistically significant. The thickness of the vessel media did not change significantly with age. The pulmonary artery and vein strips were less extensible in the older age groups, the main change occurring in the elastic phase of the vascular stress/strain curves. It is suggested that changes in the elastic tissue at a molecular and lamellar level are responsible for the increasing stiffness of pulmonary vessels rather than changes in the medial collagen content.

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  • Reduced alveolar-capillary density and changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging.

    “Reduced alveolar-capillary density as well as changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging (24–28).”

    From Aging and Lung Disease (2020) · cites this paper as [27]

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Research works printed but not linked: 2

  1. Bertram, C. D., Lee, G. de J., Rajagopalan, B., and Stallard, T. (1977). Measurement of the dimensions of the extraparenchymal pulmonary veins in the dog. Journal of Physiology, 272, 101-102.
  2. Dunnill, M. S_ (1968). Quantitative methods in his- tology. In: Recent Advances in Clinical Pathology, Series V, edited by S. C. Dyke, pp. 401-416.

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Authors
Mackay, E. H., Banks, J., Sykes, B., & Lee, G.
Affiliations
University of Oxford (GB)
Venue
Thorax
Publisher
BMJ
Published
1978-06-01
Volume
33
Issue
3
Pages
335-344
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.33.3.335
PMC
PMC470893
OpenAlex
W2051173440
Cited by
102
References
24
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 4 · 2012: 6
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Keywords
pulmonary vessels, aging, vascular stiffness, collagen content, elastin, pulmonary artery, pulmonary veins, hydroxyproline, elastic tissue
MeSH terms
Adolescent, Adult, Aged, Aging, Child, Collagen, Compliance, Elastin, Female, Humans, Male, Middle Aged, Muscle, Smooth, Pulmonary Artery, Pulmonary Veins

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