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Cited by 59Obstructive Sleep Apnea ResearchBlood Pressure and Hypertension StudiesSleep and related disorders

Nasal CPAP and weight loss in hypertensive patients with obstructive sleep apnoea.

Open access
Rauscher, H, Formanek, D, Popp, W, Zwick, H·1993·Thorax
DOI 10.1136/thx.48.5.529PMC PMC464508
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Abstract

BACKGROUND: The high prevalence of obstructive sleep apnoea (OSA) in patients with systemic hypertension and of hypertension in patients with OSA suggests a causal link between the two disorders. This study was carried out to determine whether nasal continuous positive airway pressure (CPAP) and weight loss affect daytime hypertension in OSA. METHODS: Sixty hypertensive patients with OSA took part in the study; 33 accepted nasal CPAP and used their machine for 5.7 (0.2) hours per night, and the remaining 27 patients refused nasal CPAP and upper airway surgery so the only therapeutic intervention was a recommendation of weight loss. A significant change in hypertension during follow up was defined as either a change in mean blood pressure of at least 10 mm Hg (or more than 8%) without a change in drug treatment, or a reduction in drug dosage with mean blood pressure within these limits. Weight loss was defined as a body mass index of at least 5% below the baseline value. RESULTS: After 512 (41) days, hypertension had become less severe in seven of 12 patients (58%) treated with weight loss only, in eight of 28 patients (29%) with nasal CPAP only, in two of five patients with nasal CPAP and weight loss, and in one of 15 patients without nasal CPAP or weight loss. Multivariate analysis of variance with the outcome of hypertension at follow up as the dependent variable revealed that only the percentage change in body mass index significantly contributed to the course of hypertension. CONCLUSION: The course of hypertension in OSA is more closely linked to weight loss than to elimination of sleep apnoea by nasal CPAP.

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  • In surgery intervention studies, the apnoea-hypopnoea index decreased by 44±22 h−1 (77%).

    “The AHI decreased by 44±22 h−1 (77%) (table e3) 29–31.”

    From Non-CPAP therapies in obstructive sleep apnoea (2011) · cites this paper as [29]

    The Methods state that patients who declined CPAP also refused upper-airway surgery; this was not a surgery intervention study. The Results attribute the AHI reduction to nasal CPAP, not surgery, and do not report a decrease of 44±22 h−1 (77%). (LLM, conf=0.88)

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Research works printed but not linked: 5

  1. [11]11. Williams AJ, Houston D, Finberg S, Lam C, Kinney JL, Santiago S. Sleep apnea syndromes and essential hyper- tension. Am J7Cardiol 1985;55:1019-22.
  2. [14]14. Staats BA, Offord KP, Richardson JW, Westbrook PR, Fredrickson PA. Long-term follow up of obstructive sleep apnea patients treated with tracheostomy. Sleep Res 1988;17:262.
  3. [24]24. Tilkian AG, Guilleminault C, Schroeder JS, Lehrman KU, Simmons FB, Dement WC. Hemodynamics in sleep- induced apnea: studies during wakefulness and sleep. Ann Intern Med 1976;85:714-9.
  4. [25]25. Goldstein DS. Plasma catecholamines and essential hypertension. Hypertension 1983;5:86-99.
  5. [31]31. Guilleminault C, Stoohs R, Duncan S. Snoring (I): Daytime sleepiness in regular heavy snorers. Chest 1991; 99:40-8.

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Authors
Rauscher, H., Formanek, D., Popp, W., & Zwick, H.
Venue
Thorax
Publisher
BMJ
Published
1993-05-01
Volume
48
Issue
5
Pages
529-533
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.48.5.529
PMC
PMC464508
OpenAlex
W2099908875
Cited by
58
References
29
Citations by year
2025: 1 · 2023: 2 · 2020: 1 · 2019: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obstructive sleep apnea, hypertension, nasal continuous positive airway pressure, weight loss, body mass index, daytime blood pressure, upper airway surgery, comorbidities
MeSH terms
Female, Humans, Hypertension, Male, Middle Aged, Positive-Pressure Respiration, Sleep Apnea Syndromes, Weight Loss, Body Mass Index

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