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Effects of upper respiratory tract infections in patients with cystic fibrosis.
Open accessAbstract
BACKGROUND: The polymerase chain reaction has improved the detection of picornaviruses and rhinoviruses and our understanding of their role in reversible airways disease. The effects of colds on lower respiratory morbidity and bacterial colonisation in cystic fibrosis remain uncertain. METHODS: Children with cystic fibrosis were evaluated regularly in the clinic and the parents notified the investigators when their child developed a cold. Nasopharyngeal specimens were collected at the start of the infection for polymerase chain reaction, bacteriology was also undertaken and again three weeks later, and pulmonary function was measured in children aged > or = 6 years at four day intervals for three weeks. The effects of colds on rate of progression of cystic fibrosis were assessed by pulmonary function, Shwachman scores, and radiology. RESULTS: Thirty eight children suffered 147 colds over 17 months. Picornaviruses were detected in 51 (43%) of 119 nasopharyngeal specimens, and 21 of the 51 were further identified as rhinoviruses. Pulmonary dysfunction was similar following picornavirus and non-picornavirus infections; the mean change from baseline in forced expiratory volume in one second (FEV1) was -16.5% and -10.3% at 1-4 days and 21-24 days, respectively, after onset of a cold. Children who experienced more colds than average had evidence of disease progression with reduction in Shwachman score, increasing Chrispin-Norman score, and greater deterioration in FEV1 per annum. Ten of 12 new bacterial infections were associated with a cold. CONCLUSIONS: Picornavirus and non-picornavirus colds are associated with pulmonary function abnormalities and disease progression in patients with cystic fibrosis, and predispose to secondary bacterial infection and colonisation.
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“Bacteria adhere to various host cell molecules on the airway epithelium, including platelet-activating factor receptor (PAF-r), outer membrane protein P5-homologous fimbriae (P5 fimbriae), carcinoembryonic antigen-related cellular adhesion 1 (CEACAM-1), and intercellular adhesion molecule 1 (ICAM-1) (37, 124, 251).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [37]
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Metadata
- Authors
- Collinson, J., Nicholson, K. G., Cancio, E., Ashman, J., Ireland, D. C., Hammersley, V, Kent, J., & O'Callaghan, C.
- Affiliations
- University of Leicester (GB)
- ORCID
- Hammersley, V
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1996-11-01
- Volume
- 51
- Issue
- 11
- Pages
- 1115-1122
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC1090523
- OpenAlex
- W2138192279
- Cited by
- 173
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Cystic Fibrosis Trust
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
- Keywords
- cystic fibrosis, upper respiratory tract infection, common cold, picornavirus, rhinovirus, lung function, disease progression, bacterial colonization, secondary bacterial infection, nasopharyngeal viral detection, children
- MeSH terms
- Adolescent, Bacterial Infections, Child, Child, Preschool, Common Cold, Cystic Fibrosis, Female, Forced Expiratory Volume, Humans, Infant, Male, Opportunistic Infections, Picornaviridae Infections, Respiratory Tract Infections, Vital Capacity, Disease Progression
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