The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Increased exhaled nitric oxide in patients with stable chronic obstructive pulmonary disease
Open accessAbstract
BACKGROUND: Nitric oxide (NO) plays an important role as an inflammatory mediator in the airways. Since chronic obstructive pulmonary disease (COPD) is characterised by airway inflammation, a study was undertaken to determine NO levels in the exhaled air of patients with COPD. METHODS: Two groups of patients with clinically stable COPD were studied, 10 current smokers and 10 ex-smokers. Two control groups of healthy subjects consisting of 10 current smokers and 20 non-smokers were also studied. Exhaled NO levels were measured by the collection bag technique and NO chemiluminescence analyser. RESULTS: Mean (SE) levels of exhaled NO in ex-smokers and current smokers with COPD (25.7 (3.0) ppb and 10.2 (1.4) ppb, respectively) were significantly higher than in non-smoker and current smoker control subjects (9.4 (0.8) ppb and 4.6 (0.4) ppb, respectively). In current smokers with COPD exhaled levels of NO were significantly lower than in ex-smokers. In this latter group of patients there was a significant negative correlation between smoking history (pack years) and levels of exhaled NO (r = -0.8, p = 0.002). A positive correlation was seen between forced expiratory volume in one second (FEV1) and levels of exhaled NO (r = 0.65, p = 0.001) in patients with COPD. CONCLUSIONS: These data show that exhaled NO is increased in patients with stable COPD, both current and ex-smokers, compared with healthy control subjects.
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Cites
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
The biology of nitrogen oxides in the airways
Gaston, B., Drazen, J. M., Loscalzo, J., & Stamler, J. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.7508323 · Cited by 918 · cited 1×
“In the past, nitric oxide (NO) was regarded exclusively as an atmospheric contaminant. Currently, however, it is thought to play an important endogenous signalling role in the physiological control of airway function and in the pathophysiology of airway diseases.”
Background
Cited by
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Mediators of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Hansel, T. T., Kharitonov, S. A., Donnelly, L. E., Erin, E. M., Currie, M. G., Moore, W. M., Manning, P. T., Recker, D. P., & Barnes, P. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0633fje · Cited by 208
Markers of lung disease in exhaled breath: nitric oxide
Choi, J., Hoffman, L. A., Rodway, G. W., & Sethi, J. M. (2006) · Biological Research For Nursing · doi:10.1177/1099800405286131 · Cited by 43
Metadata
- Authors
- Corradi, M., Majori, M., Cacciani, G. C., Consigli, G. F., de'Munari, E., & Pesci, A.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1999-07-01
- Volume
- 54
- Issue
- 7
- Pages
- 572-575
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2161768389
- Cited by
- 167
- References
- 2
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Corradi, M., Majori, M., Cacciani, G. C., Consigli, G. F., de'Munari, E., & Pesci, A. (1999). Increased exhaled nitric oxide in patients with stable chronic obstructive pulmonary disease. Thorax. https://doi.org/10.1136/thx.54.7.572
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