Cited by 27Antioxidants, Aging, Portulaca oleraceaFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

Fisetin, a Potential Caloric Restriction Mimetic, Attenuates Senescence Biomarkers in Rat Erythrocytes

Singh, Sandeep, Garg, Geetika, Singh, Abhishek Kumar, Bissoyi, Akalabya, Rizvi, Syed Ibrahim·2019·Biochemistry and Cell Biology

Abstract

An imbalanced redox status is a hallmark of the aging process. Caloric restriction mimetics (CRMs) are compounds that produce caloric restriction benefits at the molecular, cellular, and physiological level, translating into health-promoting effects. Fisetin is the least explored CRM, and its role in modulating oxidative stress during aging is not clearly known. This study investigated the antioxidative and protective potential of fisetin in a rat model of d-galactose (D-gal)-induced accelerated senescence, and in naturally aged rat erythrocytes. Young rats (4 months), aged D-gal-induced rats [24 months; 500 mg/kg body mass (b.m.); subcutaneous injection] and naturally aged D-gal-induced rats [24 months; 500 mg/kg b.m.; subcutaneous injection] were supplemented with fisetin (15 mg/kg b.m.; orally) for 6 weeks. The resulting data indicated that supplementation with fisetin suppresses aging-induced increases in the levels of reactive oxygen species, eryptosis, lipid peroxidation, and protein oxidation. Our data also show that fisetin significantly increases the levels of antioxidants and activates the plasma membrane redox system. Taken together, the findings show that a fisetin-rich diet could be an anti-aging intervention strategy.

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Registry

Crossref · 10.1139/bcb-2018-0159

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58 of 58 references verified0 citation errors · 0 not checkable

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  • In vivo, 6-week oral administration of fisetin drastically reduced senescence, ROS, lipid peroxidation and protein oxidation in a rat model of induced aging, and lifespan extension has been reported in mice.

    “In vivo, 6-week oral administration of fisetin drastically reduced senescence, ROS, lipid peroxidation and protein oxidation in a rat model of induced aging, and lifespan extension has been reported in mice [235,272].”

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Authors
Singh, S., Garg, G., Singh, A. K., Bissoyi, A., & Rizvi, S. I.
Affiliations
  • University of Allahabad (IN)
  • National Institute of Technology Raipur (IN)
Corresponding author
  • Singh, Sandeep
  • Garg, Geetika
Venue
Biochemistry and Cell Biology
Published
2019-08
Volume
97
Issue
4
Pages
480-487
ISSN
  • 0829-8211 (ISSN-L)
  • 1208-6002
OpenAlex
W2908894911
Cited by
27
References
58
Citations by year
2026: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 3
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemistry and Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
fisetin, caloric restriction mimetics, cellular senescence, erythrocytes, D-galactose-induced aging, oxidative stress, eryptosis, lipid peroxidation, protein oxidation, reactive oxygen species, antioxidants, plasma membrane redox system, anti-aging interventions
MeSH terms
Animals, Antioxidants, Erythrocytes, Flavonoids, Galactose, Injections, Subcutaneous, Male, Biomarkers, Cellular Senescence, Rats, Wistar, Caloric Restriction, Flavonols, Rats

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