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LncRNA H19 promotes inflammatory response induced by cerebral ischemia–reperfusion injury through regulating the miR-138-5p–p65 axis

Li, Hui, Tang, Chenglu, Wang, Dan·2020·Biochemistry and Cell Biology
DOI 10.1139/bcb-2019-0281
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Abstract

Recent studies have shown that long non-coding RNA(LncRNA) H19 is up-regulated in the brain of rats suffering from cerebral ischemia–reperfusion (I/R) injury, inducing severe disability and mortality. Little was known about the molecular mechanisms underlying the involvement of H19 in cerebral I/R injury. In this study, a rat model of I/R was induced by transient middle cerebral artery occlusion (tMCAO). PC-12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) were used as an in vitro model. Our results show that H19 is up-regulated in both in vivo and in our in vitro model. Further study indicated that knockdown of H19 promotes cell proliferation, decreases the rate of cell apoptosis, and ameliorates inflammation after OGD/R simulation. Our in vivo study shows that H19 knockdown ameliorates inflammation and improves neurological function in our rat model of tMCAO. Remarkably, the results from our luciferase reporter assays suggest that H19 negatively regulates the expression of miR-138-5p, and p65 was identified as a target of miR-138-5p. To sum up, this study demonstrated that H19 promotes an inflammatory response and improves neurological function in a rat model of tMCAO by regulating the expression of miR-138-5p and p65. This study reveals the important role and underlying mechanism of H19 in the progress of cerebral I/R injury, which could serve as a potential target for further treatment.

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Research works printed but not linked: 59

  1. 10.1016/j.ijbiomac.2017.04.091 · DOI
  2. 10.1038/jcbfm.2012.16 · DOI
  3. 10.1016/j.ijbiomac.2018.10.033 · DOI
  4. 10.1139/cjpp-2017-0586 · DOI
  5. 10.1016/S0140-6736(08)60694-7 · DOI
  6. 10.1016/j.neuropharm.2008.01.005 · DOI
  7. 10.1016/j.pbb.2007.04.015 · DOI
  8. 10.1038/nm.2507 · DOI
  9. 10.1038/nrneurol.2016.125 · DOI
  10. 10.1155/2018/5945128 · DOI
  11. 10.1242/dev.036061 · DOI
  12. 10.1002/bies.200900170 · DOI · Paper page
  13. 10.2147/JIR.S35629 · DOI
  14. 10.1172/JCI118543 · DOI
  15. 10.1016/j.bbrc.2013.10.151 · DOI
  16. 10.1016/j.cell.2010.06.040 · DOI · Paper page
  17. 10.1097/00019052-200102000-00014 · DOI
  18. 10.1007/s12035-010-8102-z · DOI
  19. 10.1007/978-94-017-7215-0_8 · DOI
  20. 10.1097/00004647-199607000-00003 · DOI
  21. 10.1172/JCI116967 · DOI
  22. 10.1016/S2214-109X(13)70089-5 · DOI
  23. 10.1016/j.expneurol.2007.05.017 · DOI
  24. 10.1042/BJ20120680 · DOI
  25. 10.1002/mus.1037 · DOI
  26. 10.1016/j.jneumeth.2008.12.028 · DOI
  27. 10.1186/1742-2094-10-28 · DOI
  28. 10.1038/srep11155 · DOI
  29. 10.1371/journal.pone.0000845 · DOI
  30. 10.1016/j.bbamcr.2010.01.010 · DOI
  31. 10.1161/CIR.0000000000000350 · DOI · Paper page
  32. 10.1007/s12975-016-0479-1 · DOI
  33. 10.3727/096504017X15017209042610 · DOI
  34. 10.1186/1752-0509-8-83 · DOI
  35. 10.1038/jcbfm.2012.101 · DOI
  36. 10.1161/CIRCRESAHA.108.193102 · DOI
  37. 10.1186/s12943-015-0458-2 · DOI
  38. 10.1038/nprot.2008.73 · DOI · Paper page
  39. 10.4103/0976-3147.118787 · DOI
  40. 10.1097/00004647-200003000-00017 · DOI
  41. 10.3892/etm.2016.3021 · DOI · Paper page
  42. 10.1016/j.yexcr.2018.03.042 · DOI · Paper page
  43. 10.18632/oncotarget.18512 · DOI
  44. 10.1161/STROKEAHA.113.000731 · DOI
  45. 10.14336/AD.2016.0530 · DOI
  46. Wei Z.J., 2017, Eur. Rev. Med. Pharmacol. Sci., 21, 2177
  47. 10.1016/j.brainresbull.2013.06.001 · DOI
  48. 10.7150/ijms.27543 · DOI
  49. 10.1007/s12035-016-0246-z · DOI
  50. 10.1038/srep06088 · DOI
  51. 10.1038/cddis.2016.57 · DOI
  52. 10.1016/j.brainres.2011.10.007 · DOI
  53. 10.1111/j.1742-4658.2012.08694.x · DOI
  54. 10.1097/00001756-199806220-00041 · DOI
  55. 10.1186/1471-2121-14-26 · DOI
  56. 10.1016/S0022-510X(97)00154-8 · DOI
  57. 10.1007/s11064-015-1647-5 · DOI
  58. 10.1016/j.biopha.2018.03.040 · DOI
  59. 10.1159/000447809 · DOI

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Metadata

Authors
Li, H., Tang, C., & Wang, D.
Affiliations
  • Department of Neurology, The First People’s Hospital of Tianmen city in Hubei Province, Tianmen City, Hubei Province, 431700, China.
  • Department of Gastroenterology, Wuhan Fifth Hospital, Wuhan City, Hubei Province, 430050, China.
  • Department of Geriatrics, Hefei Binhu Hospital, Hefei City, Anhui Province, 230601, China.
Venue
Biochemistry and Cell Biology
Publisher
Canadian Science Publishing
Published
2020-08
Volume
98
Issue
4
Pages
525-536
ISSN
  • 0829-8211
  • 1208-6002
DOI
10.1139/bcb-2019-0281
Cited by
35
References
3
Language
en
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)

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CoChat. (2026). Citation check: LncRNA H19 promotes inflammatory response induced by cerebral ischemia–reperfusion injury through regulating the miR-138-5p–p65 axis. https://app.cochat.ai/papers/10.1139/bcb-2019-0281
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Li, H., Tang, C., & Wang, D. (2020). LncRNA H19 promotes inflammatory response induced by cerebral ischemia–reperfusion injury through regulating the miR-138-5p–p65 axis. Biochemistry and Cell Biology. https://doi.org/10.1139/bcb-2019-0281