Ursolic acid plays a protective role in obesity-induced cardiovascular diseases
Abstract
The metabolic disturbance of obesity is one of the most common risk factors of atherosclerosis. Resistin, an obesity-induced adipokine, can induce the expression of cell adhesion molecules and the attachment of monocytes to endothelial cells, which play an important role in the development of atherosclerosis. Ursolic acid, a pentacyclic triterpenoid found in fruits and many herbs, exhibits an array of biological effects such as anti-inflammatory and antioxidative properties. The aim of this study was to investigate the potential underlying mechanisms of the effect of ursolic acid on resistin-induced adhesion of U937 cells to human umbilical vein endothelial cells (HUVECs). Our data indicated that ursolic acid suppressed the adhesion of U937 to HUVECs and downregulated the expression of adhesion molecules, vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1), and E-selectin, in resistin-induced HUVECs by decreasing the production of intracellular reaction oxygen species (ROS) and attenuating the nuclear translocation of NFκB. Ursolic acid appeared to inhibit resistin-induced atherosclerosis, suggesting that ursolic acid may play a protective role in obesity-induced cardiovascular diseases.
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Triterpenic acids (OA, MA and UA) have been reported to suppress the expression of E-selectin, ICAM-1 and VCAM-1 in different cultured human endothelial cells.
“Triterpenic acids (OA, MA and UA) have been reported to suppress the expression of E-selectin, ICAM-1 and VCAM-1 in different cultured human endothelial cells [39–41], although none of these parameters showed variations after the intake of OPO and HOSO (Table 5).”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [40]
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References 38 · Cited by 17
- Authors
- Lin, Y.-T., Yu, Y.-M., Chang, W.-C., Chiang, S.-Y., Chan, H.-C., & Lee, M.-F.
- Affiliations
- China Medical University (TW)
- Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan, Taiwan.
- Chang Jung Christian University (TW)
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 2016-06
- Volume
- 94
- Issue
- 6
- Pages
- 627-633
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W2288465332
- Cited by
- 17
- References
- 38
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2018: 1 · 2017: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- ursolic acid, resistin, obesity, atherosclerosis, monocyte-endothelial cell adhesion, VCAM-1, ICAM-1, E-selectin, reactive oxygen species, NF-κB nuclear translocation, pentacyclic triterpenes, cardioprotection
- MeSH terms
- Ursolic Acid, Cardiotonic Agents, Cardiovascular Diseases, Cell Adhesion, Cell Survival, Cells, Cultured, Dose-Response Relationship, Drug, Endothelium, Vascular, Humans, Monocytes, Obesity, Triterpenes, U937 Cells, Human Umbilical Vein Endothelial Cells
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