The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
How to increase serotonin in the human brain without drugs
Open accessAbstract
For the last 4 decades, the question of how to manipulate the serotonergic system with drugs has been an important area of research in biological psychiatry, and this research has led to advances in the treatment of depression. Research on the association between various polymorphisms and depression supports the idea that serotonin plays a role, not only in the treatment of depression but also in susceptibility to depression and suicide. The research focus here has been on polymorphisms of the serotonin transporter, but other serotonin-related genes may also be involved.1–5 In the future, genetic research will make it possible to predict with increasing accuracy who is susceptible to depression. Much less attention has been given to how this information will be used for the benefit of individuals with a serotonin-related susceptibility to depression, and little evidence exists concerning strategies to prevent depression in those with such a susceptibility. Various studies have looked at early intervention in those with prodromal symptoms as well as at population strategies for preventing depression.6–11 Obviously, prevention is preferable to early intervention; moreover, although population strategies are important, they are ideally supplemented with preventive interventions that can be used over long periods of time in targeted individuals who do not yet exhibit even nonclinical symptoms. Clearly, pharmacologic approaches are not appropriate, and given the evidence for serotonin's role in the etiology and treatment of depression, nonpharmacologic methods of increasing serotonin are potential candidates to test for their ability to prevent depression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The benefits of frequent positive affect: Does happiness lead to success?
Lyubomirsky, S., King, L., & Diener, E. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.6.803 · Cited by 7,143
Personality Development: Stability and Change
Caspi, A., Roberts, B. W., & Shiner, R. L. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141913 · Cited by 2,699
Positive emotions in early life and longevity: Findings from the nun study.
Danner, D. D., Snowdon, D. A., & Friesen, W. V. (2001) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.80.5.804 · Cited by 1,406
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160
Positive Psychology in Clinical Practice
Lee Duckworth, A., Steen, T. A., & Seligman, M. E. P. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144154 · Cited by 1,095 · cited 1×
“positive emotions and agreeableness foster congenial relationships with others.(28,29) This in turn will create the condi-”
BackgroundGolden, R. N., Gaynes, B. N., Ekstrom, R. D., Hamer, R. M., Jacobsen, F. M., Suppes, T., Wisner, K. L., & Nemeroff, C. B. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.656 · Cited by 896
Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001336 · Cited by 421
Brummett, B. H., Barefoot, J. C., Siegler, I. C., Clapp-Channing, N. E., Lytle, B. L., Bosworth, H. B., Williams, R. B., & Mark, D. B. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200103000-00010 · Cited by 396
Weiss, A., & Costa, P. T. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000181272.58103.18 · Cited by 311 · cited 1×
“For example, the opposite of hostility, agreeableness, was a significant protective factor against mortality in a sample of older, frail participants.(19)”
BackgroundAnguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001328 · Cited by 276
Cited by
Rodriguez-Ayllon, M., Cadenas-Sánchez, C., Estévez-López, F., Muñoz, N. E., Mora-Gonzalez, J., Migueles, J. H., Molina-García, P., Henriksson, H., Mena-Molina, A., Martínez-Vizcaíno, V., et al. (2019) · Sports Medicine · doi:10.1007/s40279-019-01099-5 · Cited by 1,360
Mandolesi, L., Polverino, A., Montuori, S., Foti, F., Ferraioli, G., Sorrentino, P., & Sorrentino, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00509 · Cited by 1,038
Bioactive compounds in banana and their associated health benefits – A review
Singh, B., Singh, J. P., Kaur, A., & Singh, N. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.03.033 · Cited by 531
Physical activity and subjective well-being in healthy individuals: a meta-analytic review
Buecker, S., Simacek, T., Ingwersen, B., Terwiel, S., & Simonsmeier, B. A. (2021) · Health Psychology Review · doi:10.1080/17437199.2020.1760728 · Cited by 374
Evolution of Well-Being and Happiness After Increases in Consumption of Fruit and Vegetables
Mujcic, R., & J.Oswald, A. (2016) · American Journal of Public Health · doi:10.2105/ajph.2016.303260 · Cited by 293
Metadata
- Authors
- Young, S. N.
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2007-11
- Volume
- 32
- Issue
- 6
- Pages
- 394-399
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- OpenAlex
- W1596412005
- Cited by
- 335
- References
- 15
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: How to increase serotonin in the human brain without drugs. https://app.cochat.ai/papers/10.1139/jpn.0738
- The paper
- Young, S. N. (2007). How to increase serotonin in the human brain without drugs. Journal of Psychiatry and Neuroscience. https://doi.org/10.1139/jpn.0738
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
