The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Characteristics of γ-H2AX foci at DNA double-strand breaks sites
Abstract
Phosphorylated H2AX (γ-H2AX) is essential to the efficient recognition and (or) repair of DNA double strand breaks (DSBs), and many molecules, often thousands, of H2AX become rapidly phosphorylated at the site of each nascent DSB. An antibody to γ-H2AX reveals that this highly amplified process generates nuclear foci. The phosphorylation site is a serine four residues from the C-terminus which has been evolutionarily conserved in organisms from giardia intestinalis to humans. Mice and yeast lacking the conserved serine residue demonstrate a variety of defects in DNA DSB processing. H2AX Δ/Δ mice are smaller, sensitive to ionizing radiation, defective in class switch recombination and spermatogenesis while cells from the mice demonstrate substantially increased numbers of genomic defects. γ-H2AX foci formation is a sensitive biological dosimeter and presents new and exciting opportunities to understand important biological processes, human diseases, and individual variations in radiation sensitivity. These potentialities demonstrate the importance of understanding the parameters and functions of γ-H2AX formation.
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Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Self-citationMegabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
Self-citationA critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098
Self-citationWard, J. F. (1988) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60611-x · Cited by 1,492
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
Self-citationFelsenfeld, G., & Groudine, M. (2003) · Nature · doi:10.1038/nature01411 · Cited by 1,150
Sensing and repairing DNA double-strand breaks
Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,128
Recombinational DNA double-strand breaks in mice precede synapsis
Mahadevaiah, S. K., Turner, J. M. A., Baudat, F., Rogakou, E. P., de Boer, P., Blanco-Rodríguez, J., Jasin, M., Keeney, S., Bonner, W. M., & Burgoyne, P. S. (2001) · Nature Genetics · doi:10.1038/85830 · Cited by 851
Self-citationHistone H2A variants H2AX and H2AZ
Redon, C., Pilch, D., Rogakou, E., Sedelnikova, O., Newrock, K., & Bonner, W. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00282-4 · Cited by 767
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Cited by
γH2AX: a sensitive molecular marker of DNA damage and repair
Mah, L.-J., El-Osta, A., & Karagiannis, T. C. (2010) · Leukemia · doi:10.1038/leu.2010.6 · Cited by 1,557
-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
Kinner, A., Wu, W., Staudt, C., & Iliakis, G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn550 · Cited by 1,256
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
Masumoto, H., Hawke, D., Kobayashi, R., & Verreault, A. (2005) · Nature · doi:10.1038/nature03714 · Cited by 544
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510015 · Cited by 518
Self-citationInduction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish
Choi, J. E., Kim, S., Ahn, J. H., Youn, P., Kang, J. S., Park, K., Yi, J., & Ryu, D.-Y. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.12.012 · Cited by 494
Metadata
- Authors
- Pilch, D. R., Sedelnikova, O. A., Redon, C., Celeste, A., Nussenzweig, A., & Bonner, W. M.
- Venue
- Biochemistry and Cell Biology
- Publisher
- Canadian Science Publishing
- Published
- 2003-06-01
- Volume
- 81
- Issue
- 3
- Pages
- 123-129
- ISSN
- 0829-8211 (ISSN-L)
- 1208-6002
- OpenAlex
- W2152745581
- Cited by
- 451
- References
- 35
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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