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Role of creatine phosphokinase in cellular function and metabolism
Abstract
This paper summarizes the data concerning the role of the creatine phosphokinase system in muscle cells with main attention to the cardiac muscle. Creatine phosphokinase isoenzymes play a key role in the intracellular energy transport from mitochondria to myofibrils and other sites of energy utilization. Due to the existence of the creatine phosphate pathway for energy transport, intracellular creatine phosphate concentration is apparently an important regulatory factor for muscle contraction which influences the contractile force by determining the rate of regeneration of ATP directly available for myosin ATPase, and at the same time controls the activator calcium entry into the myoplasm across the surface membrane of the cells.
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Citations
Cited by
Wallimann, T., Wyss, M., Brdiczka, D., Nicolay, K., & Eppenberger, H. M. (1992) · Biochemical Journal · doi:10.1042/bj2810021 · Cited by 2,011
The creatine kinase system and pleiotropic effects of creatine
Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011) · Amino Acids · doi:10.1007/s00726-011-0877-3 · Cited by 797
CNS energy metabolism as related to function
Ames, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00038-2 · Cited by 663
Wallimann, T., Schlösser, T., & Eppenberger, H. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42981-4 · Cited by 202
Oral creatine supplementation and skeletal muscle metabolism in physical exercise
Mesa, J. L. M., Ruiz, J. R., Gonz??lez-Gross, M. M., Guti??rrez S??inz, ?., & Castillo Garz??n, M. J. (2002) · Sports Medicine · doi:10.2165/00007256-200232140-00003 · Cited by 103
Metadata
- Authors
- Saks, V. A., Rosenshtraukh, L. V., Smirnov, V. N., & Chazov, E. I.
- Venue
- Canadian Journal of Physiology and Pharmacology
- Publisher
- Canadian Science Publishing
- Published
- 1978-10-01
- Volume
- 56
- Issue
- 5
- Pages
- 691-706
- ISSN
- 0008-4212 (ISSN-L)
- 1205-7541
- OpenAlex
- W1989693351
- Cited by
- 303
- References
- 0
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Role of creatine phosphokinase in cellular function and metabolism. https://app.cochat.ai/papers/10.1139/y78-113
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- Saks, V. A., Rosenshtraukh, L. V., Smirnov, V. N., & Chazov, E. I. (1978). Role of creatine phosphokinase in cellular function and metabolism. Canadian Journal of Physiology and Pharmacology. https://doi.org/10.1139/y78-113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
