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Digital Microfluidics
Abstract
Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.
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Cited by
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Heikenfeld, J., Jajack, A., Rogers, J., Gutruf, P., Tian, L., Pan, T., Li, R., Khine, M., Kim, J., Wang, J., et al. (2018) · Lab on a Chip · doi:10.1039/c7lc00914c · Cited by 1,434
Advances in Microfluidic Materials, Functions, Integration, and Applications
Nge, P. N., Rogers, C. I., & Woolley, A. T. (2013) · Chemical Reviews · doi:10.1021/cr300337x · Cited by 958
Molecular Digital Data Storage Using DNA
Ceze, L., Nivala, J., & Strauss, K. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0125-3 · Cited by 551
Active droplet sorting in microfluidics: a review
Xi, H.-D., Zheng, H., Guo, W., Gañán-Calvo, A. M., Ai, Y., Tsao, C.-W., Zhou, J., Li, W., Huang, Y., Nguyen, N.-T., et al. (2017) · Lab on a Chip · doi:10.1039/c6lc01435f · Cited by 369
Recent Advances in Droplet Microfluidics
Ding, Y., Howes, P. D., & deMello, A. J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05047 · Cited by 357
Metadata
- Authors
- Choi, K., Ng, A. H. C., Fobel, R., & Wheeler, A. R.
- Venue
- Annual Review of Analytical Chemistry
- Publisher
- Annual Reviews
- Published
- 2012-07-19
- Volume
- 5
- Issue
- 1
- Pages
- 413-440
- ISSN
- 1936-1327 (ISSN-L)
- 1936-1335
- OpenAlex
- W4239130850
- Cited by
- 817
- References
- 0
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Digital Microfluidics. https://app.cochat.ai/papers/10.1146/annurev-anchem-062011-143028
- The paper
- Choi, K., Ng, A. H. C., Fobel, R., & Wheeler, A. R. (2012). Digital Microfluidics. Annual Review of Analytical Chemistry. https://doi.org/10.1146/annurev-anchem-062011-143028
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
