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Cited by 215Veterinary Oncology ResearchHuman-Animal Interaction StudiesVeterinary Pharmacology and Anesthesia

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Dogs as a Model for Cancer

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Gardner, Heather L., Fenger, Joelle M., London, Cheryl A.·2016·Annual Review of Animal Biosciences
DOI 10.1146/annurev-animal-022114-110911PMC PMC6314649
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Abstract

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts with respect to clinical presentation, histological features, molecular profiles, and response and resistance to therapy, as well as the evolution of drug-resistant metastases. In several instances the incorporation of dogs with cancer into the preclinical development path of cancer therapeutics has influenced outcome by helping to establish pharmacokinetic/pharmacodynamics relationships, dose/regimen, expected clinical toxicities, and ultimately the potential for biologic activity. As our understanding regarding the molecular drivers of canine cancers has improved, unique opportunities have emerged to leverage this spontaneous model to better guide cancer drug development so that therapies likely to fail are eliminated earlier and therapies with true potential are optimized prior to human studies. Both pets and people benefit from this approach, as it provides dogs with access to cutting-edge cancer treatments and helps to insure that people are given treatments more likely to succeed.

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Metadata

Authors
Gardner, H. L., Fenger, J. M., & London, C. A.
Affiliations
  • Department of Veterinary Clinical Sciences and
  • The Ohio State University (US)
ORCID
Venue
Annual Review of Animal Biosciences
Publisher
Annual Reviews
Published
2016-02-15
Volume
4
Issue
1
Pages
199-222
ISSN
  • 2165-8102 (ISSN-L)
  • 2165-8110
DOI
10.1146/annurev-animal-022114-110911
PMC
PMC6314649
OpenAlex
W1894349587
Cited by
215
References
9
Citations by year
2026: 22 · 2025: 27 · 2024: 29 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 22 · 2019: 17 · 2018: 11 · 2017: 10 · 2016: 3
FWCI
1.42
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Animal Biosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (K01OD019923)
Topics
  • Health Sciences › Veterinary › Small Animals › Veterinary Oncology Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
  • Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
Keywords
canine cancer, dogs as cancer models, spontaneous tumors, preclinical drug development, pharmacokinetics, pharmacodynamics, drug resistance, metastasis, clinical toxicity, companion animal oncology
MeSH terms
Animals, Animals, Newborn, Antineoplastic Agents, Disease Models, Animal, Dog Diseases, Dogs, Humans, Neoplasms

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