Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Alizadeh, Ash A.; Eisen, Michael B.; Davis, R. Eric; Ma, Chi; Lossos, Izidore S.; Rosenwald, Andreas; Boldrick, Jennifer C.; Sabet, Hajeer; Tran, Truc; Yu, Xin; Powell, John I.; Yang, Liming; Marti, Gerald E.; Moore, Troy; Hudson, James; Lu, Lisheng; Lewis, David B.; Tibshirani, Robert; Sherlock, Gavin; Chan, Wing C.; Greiner, Timothy C.; Weisenburger, Dennis D.; Armitage, James O.; Warnke, Roger; Levy, Ronald; Wilson, Wyndham; Grever, Michael R.; Byrd, John C.; Botstein, David; Brown, Patrick O.; Staudt, Louis M.

doi:10.1038/35000501

Cited by 9,925Lymphoma Diagnosis and TreatmentBreast Cancer Treatment StudiesGene expression and cancer classification

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Alizadeh, Ash A., Eisen, Michael B., Davis, R. Eric, Ma, Chi, Lossos, Izidore S., Rosenwald, Andreas, Boldrick, Jennifer C., Sabet, Hajeer +23 more·2000·Nature

DOI 10.1038/35000501

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Abstract

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells ('activated B-like DLBCL'). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer.

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Tumor samples have discrete transcriptome profile differences.
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From Rare and common variants: twenty arguments (2012) · cites this paper as [89]

Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
Self-citation
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516 · see citing works
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609 · see citing works
Self-citation
A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]
Harris, N. L., Jaffe, E., Stein, H., Pm, B., Jk, C., Cleary, M. L., Delsol, G., Peeters, C., Falini, B., & Gatter, K. C. (1994) · Blood · doi:10.1182/blood.v84.5.1361.1361 · Cited by 6,312 · see citing works
A Predictive Model for Aggressive Non-Hodgkin's Lymphoma
The International Non-Hodgkin's Lymphoma Prognostic Factors Project (1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291402 · Cited by 4,950 · see citing works
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
Alon, U. S., Barkai, N., Notterman, D. A., Gish, K., Ybarra, S. E., Mack, D. H., & Levine, A. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6745 · Cited by 4,170 · see citing works
A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma
The Non-Hodgkin's Lymphoma Classification Project (1997) · Blood · doi:10.1182/blood.v89.11.3909 · Cited by 2,456 · see citing works
Handbook of Experimental Immunology.
Denman, A. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-68-6-1376_1 · Cited by 2,414 · see citing works
Comparison of a Standard Regimen (CHOP) with Three Intensive Chemotherapy Regimens for Advanced Non-Hodgkin's Lymphoma
Fisher, R. I., Gaynor, E. R., Dahlberg, S., Oken, M. M., Grogan, T. M., Mize, E. M., Glick, J. H., Coltman, C. A., & Miller, T. P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304083281404 · Cited by 2,148 · see citing works
Use of a cDNA microarray to analyse gene expression patterns in human cancer
DeRisi, J. L., Penland, L., Brown, P. O., Bittner, M. L., Meltzer, P. S., Ray, M., Chen, Y.-W., Su, Y. A., & Trent, J. M. (1996) · Nature Genetics · doi:10.1038/ng1296-457 · Cited by 1,952 · see citing works
Self-citation
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
Perou, C. M., Jeffrey, S. S., van de Rijn, M., Rees, C. A., Eisen, M. B., Ross, D. T., Pergamenschikov, A., Williams, C. F., Zhu, S., Lee, J. C. F., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9212 · Cited by 1,402 · see citing works
Self-citation
Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells
Klein, U., Rajewsky, K., & Küppers, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1679 · Cited by 1,161 · see citing works
[12] DNA arrays for analysis of gene expression
Eisen, M. B., & Brown, P. O. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)03014-1 · Cited by 1,043 · see citing works
Self-citation
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., & Staudt, L. M. (1997) · Science · doi:10.1126/science.276.5312.589 · Cited by 945 · see citing works
Self-citation
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
Ye, B. H., Cattoretti, G., Shen, Q. “., Zhang, J., Hawe, N., de Waard, R., Leung, C. C., Nouri-Shirazi, M. A., Orazi, A., Chaganti, R. S. K., et al. (1997) · Nature Genetics · doi:10.1038/ng0697-161 · Cited by 820 · see citing works
Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W. (1997) · Science · doi:10.1126/science.275.5299.540 · Cited by 583 · see citing works
Inhibition of Fas death signals by FLIPs
Tschopp, J., Irmler, M., & Thome, M. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80223-9 · Cited by 527 · see citing works
On Some Morbid Appearances of the Absorbent Glands and Spleen
Hodgkin (1832) · Journal of the Royal Society of Medicine · doi:10.1177/095952873201700106 · Cited by 519 · see citing works
Prognostic Significance of Bcl-2 Protein Expression and Bcl-2 Gene Rearrangement in Diffuse Aggressive Non-Hodgkin's Lymphoma
Gascoyne, R. D., Adomat, S. A., Krajewski, S., Krajewska, M., Horsman, D. E., Tolcher, A. W., O’Reilly, S. E., Hoskins, P. J., Coldman, A. J., Reed, J. C., et al. (1997) · Blood · doi:10.1182/blood.v90.1.244 · Cited by 508 · see citing works
Clinical Relevance of BCL2, BCL6, and MYC Rearrangements in Diffuse Large B-Cell Lymphoma
Kramer, M. H. H., Hermans, J. H., Wijburg, E. R., et al. (1998) · Blood · doi:10.1182/blood.v92.9.3152 · Cited by 492 · see citing works
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
Tangye, S. G., Liu, Y.-J., Aversa, G., Phillips, J. H., & de Vries, J. E. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1691 · Cited by 456 · see citing works
Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.
Khan, J. I., Simon, R., Bittner, M. L., Chen, Y., Leighton, S. B., Pohida, T. J., Smith, P. D., Jiang, Y. Y., Gooden, G. C., Trent, J. M., et al. (1998) · PubMed · Cited by 437 · see citing works
The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors
Djerbi, M., Screpanti, V., Catrina, A. I., Bogen, B., Biberfeld, P., & Grandien, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1025 · Cited by 420 · see citing works
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Fukuda, T., Yoshida, T., Okada, S., Hatano, M., Miki, T., Ishibashi, K., Okabe, S., Koseki, H., Hirosawa, S., Taniguchi, M., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.3.439 · Cited by 356 · see citing works
Hormone Therapy Failure in Human Prostate Cancer: Analysis by Complementary DNA and Tissue Microarrays
Bubendorf, L., Kolmer, M., Kononen, J., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.20.1758 · Cited by 355 · see citing works
Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
Iida, S., Rao, P. H., Butler, M. P., Corradini, P., Boccadoro, M., Klein, B., CHAGANTI, R. S. K., & Dalla‐Favera, R. (1997) · Nature Genetics · doi:10.1038/ng1097-226 · Cited by 338 · see citing works
Somatic hypermutation in normal and transformed human B cells
Klein, U., Goasens, T., Fischer, M., Kanzler, H., Braeuninger, A., Rajewsky, K., & Küppers, R. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01447.x · Cited by 333 · see citing works
Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
Medema, J. P., de Jong, J., van Hall, T., Melief, C. J. M., & Offringa, R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1033 · Cited by 330 · see citing works
Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray
Wang, K., Gan, L., Jeffery, E. W., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00035-9 · Cited by 303 · see citing works
BCL-6 expression during B-cell activation
Allman, D., Jain, A., Dent, A. L., Maile, R., Selvaggi, T. A., Kehry, M. R., & Staudt, L. M. (1996) · Blood · doi:10.1182/blood.v87.12.5257.bloodjournal87125257 · Cited by 251 · see citing works
Self-citation
Clonal evolution of a follicular lymphoma: evidence for antigen selection.
Bahler, D. W., & Levy, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6770 · Cited by 250 · see citing works
Self-citation
The Lymphochip: A Specialized cDNA Microarray for the Genomic-scale Analysis of Gene Expression in Normal and Malignant LymphocytesPreprint
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Sabet, H., TRAN, T., Powell, J. I., Yang, L., MARTI, G. E., Moore, D., et al. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.71 · Cited by 247 · see citing works
Self-citation
Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
Matsuyama, T., Grossman, A., Mittrücker, H.-W., Siderovski, D. P., Kiefer, F., Kawakami, T., Richardson, C. D., Taniguchi, T., Yoshinaga, S. K., & Mak, T. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2127 · Cited by 232 · see citing works
Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67
Grogan, T., Sm, L., Spier, C., Slymen, D. J., Rybski, J. A., Cs, R., Richter, L., & Miller, T. (1988) · Blood · doi:10.1182/blood.v71.4.1157.1157 · Cited by 227 · see citing works
Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study.
Kramer, M. H. H., Hermans, J., Parker, J., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.7.2131 · Cited by 206 · see citing works
LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processesPreprint
Rabbitts, T. H. (1998) · Genes & Development · doi:10.1101/gad.12.17.2651 · Cited by 162 · see citing works
Lymphocyte homing and clinical behavior of non-Hodgkin's lymphoma.
Jalkanen, S., Joensuu, H., Söderström, K. ‐., et al. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115205 · Cited by 132 · see citing works
Molecular and immunological dissection of diffuse large B cell lymphoma: CD5+, and CD5− with CD10+ groups may constitute clinically relevant subtypes
Harada, S., Suzuki, R., Uehira, K., et al. (1999) · Leukemia · doi:10.1038/sj.leu.2401487 · Cited by 120 · see citing works
Prognostic value of serum interleukin-6 in diffuse large-cell lymphoma
Preti, H. A., Cabanillas, F., Talpaz, M., Tucker, S. L., Seymour, J. F., & Kurzrock, R. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-3-199708010-00002 · Cited by 112 · see citing works
Probing Lymphocyte Biology by Genomic-Scale Gene Expression Analysis
Alizadeh, A. A., Eisen, M. B., Botstein, D., et al. (1998) · Journal of Clinical Immunology · doi:10.1023/a:1023293621057 · Cited by 110 · see citing works
Self-citation
Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon
Zani, V. J., Asou, N., Jadayel, D. M., Heward, J., SHIPLEY, J. M., Nacheva, E. P., Takasuki, K., Catovsky, D., & Dyer, M. J. S. (1996) · Blood · doi:10.1182/blood.v87.8.3124.bloodjournal8783124 · Cited by 104 · see citing works
A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells.
Flenghi, L., Ye, B. H., Fizzotti, M., et al. (1995) · PubMed · Cited by 97 · see citing works
Regulation of Lymphocyte Cell Fate Decisions and Lymphomagenesis by BCL-6
Staudt, L. M., Dent, A. L., Shaffer, A. L., & Yu, X. (1999) · International Reviews of Immunology · doi:10.3109/08830189909088490 · Cited by 78 · see citing works
Self-citation
MUTATION OF THE VON HIPPEL-LINDAU TUMOUR SUPPRESSOR GENE IN CAPILLARY HAEMANGIOBLASTOMAS OF THE CENTRAL NERVOUS SYSTEM
Oberstraß, J., Reifenberger, G., REIFENBERGER, J., Wechsler, W., & Collins, V. P. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199606)179:2 · Cited by 76 · see citing works
Current approaches to the management of non-Hodgkin's lymphoma.
Vose, J. M. (1998) · PubMed · Cited by 74 · see citing works
Classification of lymphoid neoplasms [editorial; comment] [see comments]
Rosenberg, S. A. (1994) · Blood · doi:10.1182/blood.v84.5.1359.bloodjournal8451359 · Cited by 54 · see citing works
Augmented Expression of a Human Gene for 8-oxoguanine DNA Glycosylase (MutM) in B Lymphocytes of the Dark Zone in Lymph Node Germinal Centers
Kuo, F. C., & Sklar, J. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1547 · Cited by 47 · see citing works
Classification of lymphoid neoplasms [editorial; comment] [see comments]
Rosenberg, S. A. (1994) · Blood · doi:10.1182/blood.v84.5.1359.1359 · Cited by 42 · see citing works
The A- myb gene is preferentially expressed in tonsillar CD38+, CD39-, and sIgM- B lymphocytes and in Burkitt's lymphoma cell lines.
Golay, J., Erba, E., Bernasconi, S., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.2.543 · Cited by 30 · see citing works

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Troyanskaya, O., Cantor, M., Sherlock, G., Brown, P., Hastie, T., Tibshirani, R., Botstein, D., & Altman, R. B. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.6.520 · Cited by 4,230 · see citing works
Self-citation
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Petricoin, E. F., Ardekani, A. M., Hitt, B. A., Levine, P. J., Fusaro, V. A., Steinberg, S. M., Mills, G. B., Simone, C., Fishman, D. A., Kohn, E. C., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07746-2 · Cited by 3,236 · see citing works
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Khan, J., Wei, J. S., Ringnér, M., Saal, L. H., Ladanyi, M., Westermann, F., Berthold, F., Schwab, M., Antonescu, C. R., Peterson, C., et al. (2001) · Nature Medicine · doi:10.1038/89044 · Cited by 2,644 · see citing works
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Genuer, R., Poggi, J.-M., & Tuleau-Malot, C. (2010) · Pattern Recognition Letters · doi:10.1016/j.patrec.2010.03.014 · Cited by 2,619 · see citing works
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Schmitz, R., Wright, G. W., Huang, D. W., Johnson, C. A., Phelan, J. D., Wang, J. Q., Roulland, S., Kasbekar, M., Young, R. M., Shaffer, A. L., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801445 · Cited by 2,241 · see citing works
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Revisiting Global Gene Expression Analysis
Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.10.012 · Cited by 616 · see citing works
Common markers of proliferation
Whitfield, M. L., George, L. K., Grant, G. D., & Perou, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1802 · Cited by 650 · see citing works
Immune and stromal classification of colorectal cancer is associated with molecular subtypes and relevant for precision immunotherapy
Becht, E., de Reyniès, A., Giraldo, N. A., Pilati, C., Buttard, B., Lacroix, L., Selves, J., Sautès-Fridman, C., Laurent-Puig, P., & Fridman, W. H. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2879 · Cited by 590 · see citing works
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612 · see citing works
Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems
Birgersdotter, A., Sandberg, R., & Ernberg, I. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.009 · Cited by 591 · see citing works
Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis
Gracey, A. Y., Troll, J. V., & Somero, G. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1993 · Cited by 561 · see citing works
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns
Hastie, T., Tibshirani, R., Eisen, M. B., Alizadeh, A., Levy, R., Staudt, L., Chan, W. C., Botstein, D., & Brown, P. (2000) · Genome Biology · doi:10.1186/gb-2000-1-2-research0003 · Cited by 547 · see citing works
Self-citation
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays
Yuen, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e48 · Cited by 520 · see citing works
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance
Gillet, J.-P., Calcagno, A. M., Varma, S., Marino, M., Green, L. J., Vora, M. I., Patel, C., Orina, J. N., Eliseeva, T. A., Singal, V., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111840108 · Cited by 477 · see citing works
Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases
Sun, Y. V., & Hu, Y.-J. (2016) · Advances in Genetics · doi:10.1016/bs.adgen.2015.11.004 · Cited by 459 · see citing works
Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
Giordano, T. J., Kuick, R., Else, T., Gauger, P. G., Vinco, M., Bauersfeld, J., Sanders, D., Thomas, D. G., Doherty, G., & Hammer, G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1067 · Cited by 401 · see citing works
Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
Morton, L. M., Turner, J. J., Cerhan, J. R., Linet, M. S., Treseler, P. A., Clarke, C. A., Jack, A., Cozen, W., Maynadié, M., Spinelli, J. J., et al. (2007) · Blood · doi:10.1182/blood-2006-11-051672 · Cited by 387 · see citing works
Self-citation
Human cancer cell lines: fact and fantasy
Masters, J. R. W. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043102 · Cited by 352 · see citing works
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Palmer, C., Diehn, M., Alizadeh, A. A., & Brown, P. O. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-115 · Cited by 331 · see citing works
Self-citation
Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition
Ennishi, D., Takata, K., Béguelin, W., Duns, G., Mottok, A., Farinha, P., Bashashati, A., Saberi, S., Boyle, M., Meissner, B., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1090 · Cited by 318 · see citing works
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
Ranuncolo, S. M., Polo, J. M., Dierov, J., Singer, M., Kuo, T., Greally, J., Green, R., Carroll, M., & Melnick, A. (2007) · Nature Immunology · doi:10.1038/ni1478 · Cited by 278 · see citing works
Differential coexpression analysis using microarray data and its application to human cancer
Choi, J. K., Yu, U., Yoo, O. J., & Kim, S. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti722 · Cited by 265 · see citing works
Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic acid microarrays identifies several candidate genes as markers of malignancy
de Fraipont, F., El Atifi, M., Cherradi, N., Le Moigne, G., Defaye, G., Houlgatte, R., Bertherat, J., Bertagna, X., Plouin, P.-F., Baudin, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1075 · Cited by 261 · see citing works
InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directions
Turner, J. J., Morton, L. M., Linet, M. S., Clarke, C. A., Kadin, M. E., Vajdic, C. M., Monnereau, A., Maynadié, M., Chiu, B. C.-H., Marcos-Gragera, R., et al. (2010) · Blood · doi:10.1182/blood-2010-06-289561 · Cited by 231 · see citing works
Self-citation
Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
Soucy, T. A., Smith, P. G., & Rolfe, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0343 · Cited by 222 · see citing works
Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex
Eng, F. J., & Friedman, S. L. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.1.g7 · Cited by 222 · see citing works
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, P. R., Man, H.-W., Fontanillo, C., Wang, M., Couto, S., Breider, M., Bjorklund, C., Havens, C. G., Lu, G., Rychak, E., et al. (2015) · Blood · doi:10.1182/blood-2015-02-628669 · Cited by 203 · see citing works
On the efficiency of targeted clinical trials
Maitournam, A., & Simon, R. (2005) · Statistics in Medicine · doi:10.1002/sim.1975 · Cited by 200 · see citing works
Structural Information and Dynamical Complexity of Networks
Li, A., & Pan, Y. (2016) · IEEE Transactions on Information Theory · doi:10.1109/tit.2016.2555904 · Cited by 200 · see citing works
Gene expression changes in children with autism
Gregg, J. P., Lit, L., Baron, C. A., Hertz-Picciotto, I., Walker, W., Davis, R. A., Croen, L. A., Ozonoff, S., Hansen, R., Pessah, I. N., et al. (2008) · Genomics · doi:10.1016/j.ygeno.2007.09.003 · Cited by 181 · see citing works
Self-citation
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
Cardenas, M. G., Yu, W., Beguelin, W., Teater, M. R., Geng, H., Goldstein, R. L., Oswald, E., Hatzi, K., Yang, S.-N., Cohen, J., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85795 · Cited by 176 · see citing works
Radiogenomic Analysis to Identify Imaging Phenotypes Associated with Drug Response Gene Expression Programs in Hepatocellular Carcinoma
Kuo, M. D., Gollub, J., Sirlin, C. B., Ooi, C., & Chen, X. (2007) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2007.04.031 · Cited by 168 · see citing works
T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells
Azzaoui, I., Uhel, F., Rossille, D., Pangault, C., Dulong, J., Le Priol, J., Lamy, T., Houot, R., Le Gouill, S., Cartron, G., et al. (2016) · Blood · doi:10.1182/blood-2015-08-662783 · Cited by 168 · see citing works
Progress in the use of microarray technology to study the neurobiology of disease
Mirnics, K., & Pevsner, J. (2004) · Nature Neuroscience · doi:10.1038/nn1230 · Cited by 150 · see citing works
Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas
Rood, J. E., Hupalowska, A., & Regev, A. (2024) · Cell · doi:10.1016/j.cell.2024.07.035 · Cited by 139 · see citing works
A transcriptional profile of multicellular development inDictyostelium discoideum
Van Driessche, N., Shaw, C., Katoh, M., Morio, T., Sucgang, R., Ibarra, M., Kuwayama, H., Saito, T., Urushihara, H., Maeda, M., et al. (2002) · Development · doi:10.1242/dev.129.7.1543 · Cited by 130 · see citing works
Predicting survival for diffuse large B-cell lymphoma patients using baseline neutrophil/lymphocyte ratio
Porrata, L. F., Ristow, K., Habermann, T., Inwards, D. J., Micallef, I. N., & Markovic, S. N. (2010) · American Journal of Hematology · doi:10.1002/ajh.21849 · Cited by 124 · see citing works
Human transcriptome array for high-throughput clinical studies
Xu, W., Seok, J., Mindrinos, M. N., Schweitzer, A. C., Jiang, H., Wilhelmy, J., Clark, T. A., Kapur, K., Xing, Y., Faham, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019753108 · Cited by 124 · see citing works
Self-citation
Machine learning in bioinformatics: A brief survey and recommendations for practitioners
Bhaskar, H., Hoyle, D. C., & Singh, S. (2006) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2005.09.002 · Cited by 109 · see citing works
Resistance to <scp>Bruton tyrosine kinase</scp> inhibition in <scp>chronic lymphocytic leukaemia</scp> and <scp>non‐Hodgkin</scp> lymphoma
Nakhoda, S., Vistarop, A., & Wang, Y. L. (2023) · British Journal of Haematology · doi:10.1111/bjh.18418 · Cited by 104 · see citing works
Patient-specific data fusion defines prognostic cancer subtypes
Yuan, Y., Savage, R. S., & Markowetz, F. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002227 · Cited by 97 · see citing works
Classification of Dukes' B and C colorectal cancers using expression arrays
Frederiksen, C. M., Knudsen, S., Laurberg, S., & Ørntoft, T. F. (2003) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0434-x · Cited by 95 · see citing works
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma
Green, M. R., Vicente-Dueñas, C., Romero-Camarero, I., Long Liu, C., Dai, B., González-Herrero, I., García-Ramírez, I., Alonso-Escudero, E., Iqbal, J., Chan, W. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms4904 · Cited by 88 · see citing works
Self-citation
The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles
Sandberg, R., & Ernberg, I. (2005) · Genome Biology · doi:10.1186/gb-2005-6-8-r65 · Cited by 84 · see citing works
Signal Enhancement in Antibody Microarrays Using Quantum Dots Nanocrystals: Application to Potential Alzheimer’s Disease Biomarker Screening
Morales-Narváez, E., Montón, H., Fomicheva, A., & Merkoçi, A. (2012) · Analytical Chemistry · doi:10.1021/ac301369e · Cited by 79 · see citing works
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation
Tabach, Y., Milyavsky, M., Shats, I., Brosh, R., Zuk, O., Yitzhaky, A., Mantovani, R., Domany, E., Rotter, V., & Pilpel, Y. (2005) · Molecular Systems Biology · doi:10.1038/msb4100030 · Cited by 72 · see citing works
Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier
Carpio, C., Bouabdallah, R., Ysebaert, L., Sancho, J.-M., Salles, G., Cordoba, R., Pinto, A., Gharibo, M., Rasco, D., Panizo, C., et al. (2020) · Blood · doi:10.1182/blood.2019002395 · Cited by 72 · see citing works
Distinct subtypes of serous ovarian carcinoma identified by p53 determination☆☆☆☆☆Supplementary data associated with this article can be found at doi: 10.1016/S0090-8258(03)00608-5
Lassus, H., Leminen, A., Lundin, J., Lehtovirta, P., & Butzow, R. (2003) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.08.034 · Cited by 68 · see citing works
Apoptosis protection and survival signal by the CD53 tetraspanin antigen
Yunta, M., & Lazo, P. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206183 · Cited by 69 · see citing works
Machine Learning in Laboratory Medicine: Recommendations of the IFCC Working Group
Master, S. R., Badrick, T. C., Bietenbeck, A., & Haymond, S. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad055 · Cited by 64 · see citing works
Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2
Choi, J., Lee, K., Ingvarsdottir, K., Bonasio, R., Saraf, A., Florens, L., Washburn, M. P., Tadros, S., Green, M. R., & Busino, L. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0084-5 · Cited by 50 · see citing works
Correlation signature of the macroscopic states of the gene regulatory network in cancer
Slavov, N., & Dawson, K. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810803106 · Cited by 49 · see citing works
(De)Personalized Medicine
Horwitz, R. I., Cullen, M. R., Abell, J., & Christian, J. B. (2013) · Science · doi:10.1126/science.1234106 · Cited by 49 · see citing works
Expression of C‐IAP1, C‐IAP2 and SURVIVIN discriminates different types of lymphoid malignancies
de Graaf, A. O., Han van Krieken, J., Tönnissen, E., Wissink, W., van de Locht, L., Overes, I., Dolstra, H., de Witte, T., van der Reijden, B. A., & Jansen, J. H. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05690.x · Cited by 42 · see citing works
GO-PCA: An Unsupervised Method to Explore Gene Expression Data Using Prior Knowledge
Wagner, F. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143196 · Cited by 35 · see citing works
Novel disease targets and management approaches for diffuse large B-cell lymphoma
Wilson, W. H., Hernandez-Ilizaliturri, F. J., Dunleavy, K., Little, R. F., & O'Connor, O. A. (2010) · Leukemia & Lymphoma · doi:10.3109/10428194.2010.500045 · Cited by 34 · see citing works
Self-citation
A Tumor-specific MicroRNA Recognition System Facilitates the Accurate Targeting to Tumor Cells by Magnetic Nanoparticles
Yu, Y., Yao, Y., Yan, H., Wang, R., Zhang, Z., Sun, X., Zhao, L., Ao, X., Xie, Z., & Wu, Q. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.28 · Cited by 31 · see citing works
Representing high throughput expression profiles via perturbation barcodes reveals compound targets
Filzen, T. M., Kutchukian, P. S., Hermes, J. D., Li, J., & Tudor, M. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005335 · Cited by 31 · see citing works
New insights into redox homeostasis as a therapeutic target in B-cell malignancies
Graczyk-Jarzynka, A., Zagozdzon, R., Muchowicz, A., Siernicka, M., Juszczynski, P., & Firczuk, M. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000351 · Cited by 29 · see citing works
Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge
Ahuja, S. K., Manoharan, M. S., Harper, N. L., Jimenez, F., Hobson, B. D., Martinez, H., Ingale, P., Liu, Y.-G., Carrillo, A., Lou, Z., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.019 · Cited by 18 · see citing works
The impact of SOCS1 mutations in diffuse large B‐cell lymphoma
Mellert, K., Martin, M., Lennerz, J. K., Lüdeke, M., Staiger, A. M., Kreuz, M., Löffler, M., Schmitz, N., Trümper, L., Feller, A. C., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.16147 · Cited by 17 · see citing works
Self-citation

UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma
Bedekovics, T., Hussain, S., Feldman, A. L., & Galardy, P. J. (2015) · Blood · doi:10.1182/blood-2015-07-656678 · Cited by 48 · see citing works
Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner
Bessa, J., Köpf, M., & Bachmann, M. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903949 · Cited by 139 · see citing works
Development and Function of B Cell Subsets
Vale, A. M., Kearney, J. F., Nóbrega, A., & Schroeder, H. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397933-9.00007-2 · Cited by 17 · see citing works
Transcription Factors IRF8 and PU.1 Are Required for Follicular B Cell Development and BCL6‐driven Germinal Center Responses
Wang, H., Jain, S., Li, P., Lin, J.-X., Oh, J., Qi, C., Gao, Y., Sun, J., Sakai, T., Naghashfar, Z., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901258116 · Cited by 81 · see citing works
Cutaneous Diffuse Large B‐Cell Lymphoma, Leg Type
Cerroni, L. (2014) · doi:10.1002/9781118492505.ch13

Authors: Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., Powell, J. I., Yang, L., Marti, G. E., Moore, T., Hudson, J., Lu, L., Lewis, D. B., Tibshirani, R., Sherlock, G., Chan, W. C., Greiner, T. C., Weisenburger, D. D., Armitage, J. O., Warnke, R., Levy, R., Wilson, W., Grever, M. R., Byrd, J. C., Botstein, D., Brown, P. O., & Staudt, L. M.
Affiliations: Stanford Medicine (US)
National Institutes of Health (US)
Center for Biologics Evaluation and Research (US)
Pediatrics and Genetics (US)
University of California, Berkeley (US)
University of Nebraska Medical Center (US)
Johns Hopkins University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Staudt, Louis M.
ORCID: Alizadeh, Ash A.
Eisen, Michael B.
Davis, R. Eric
Ma, Chi
Lossos, Izidore S.
Rosenwald, Andreas
Boldrick, Jennifer C.
Yu, Xin
Yang, Liming
Moore, Troy
Lewis, David B.
Tibshirani, Robert
Sherlock, Gavin
Greiner, Timothy C.
Weisenburger, Dennis D.
Armitage, James O.
Levy, Ronald
Wilson, Wyndham
Grever, Michael R.
Byrd, John C.
Botstein, David
Brown, Patrick O.
Staudt, Louis M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-02
Volume: 403
Issue: 6769
Pages: 503-511
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35000501
OpenAlex: W2147246240
Cited by: 9,925
References: 49
Citations by year: 2026: 142 · 2025: 211 · 2024: 207 · 2023: 322 · 2022: 300 · 2021: 335 · 2020: 340 · 2019: 341 · 2018: 304 · 2017: 320 · 2016: 352 · 2015: 366 · 2014: 382 · 2013: 379 · 2012: 416
FWCI: 333.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: University of Nebraska Medical Center
School of Medicine, Stanford University
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Keywords: diffuse large B-cell lymphoma, gene expression profiling, B cell differentiation, host response, overall survival, non-Hodgkin lymphoma, tumor subtypes
MeSH terms: Adult, B-Lymphocytes, Humans, Phenotype, Tumor Cells, Cultured, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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