The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Transcription in Living Cells: Molecular Mechanisms of Bursting
Abstract
Transcription in several organisms from certain bacteria to humans has been observed to be stochastic in nature: toggling between active and inactive states. Periods of active nascent RNA synthesis known as bursts represent individual gene activation events in which multiple polymerases are initiated. Therefore, bursting is the single locus illustration of both gene activation and repression. Although transcriptional bursting was originally observed decades ago, only recently have technological advances enabled the field to begin elucidating gene regulation at the single-locus level. In this review, we focus on how biochemical, genomic, and single-cell data describe the regulatory steps of transcriptional bursts.
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In the citing paper
“In eukaryotic cells, transcription occurs in cycles [50,51,52].”
From Enhancer Function in the 3D Genome (2023) · cites this paper as [52]
Citations
Cites
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Cited by
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The Self-Organizing Genome: Principles of Genome Architecture and Function
Misteli, T. (2020) · Cell · doi:10.1016/j.cell.2020.09.014 · Cited by 742
RNA-Mediated Feedback Control of Transcriptional Condensates
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The Mediator complex as a master regulator of transcription by RNA polymerase II
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Metadata
- Authors
- Rodriguez, J., & Larson, D. R.
- Affiliations
- National Institute of Environmental Health Sciences (US)
- National Cancer Institute (US)
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2020-06-20
- Volume
- 89
- Issue
- 1
- Pages
- 189-212
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W3013821085
- Cited by
- 224
- References
- 161
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 50 · 2023: 38 · 2022: 29 · 2021: 42 · 2020: 14
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- transcriptional bursting, stochastic gene expression, gene activation, gene repression, RNA polymerase, single-cell transcriptomics, transcriptional noise
- MeSH terms
- Animals, Chromatin, DNA, Eukaryotic Cells, Gene Expression Regulation, Histones, Humans, RNA Polymerase II, RNA, Messenger, Stochastic Processes, Transcription, Genetic, Molecular Probes, Molecular Probe Techniques, Genome, Genetic Loci, Single-Cell Analysis
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