Cited by 235Gene Regulatory Network AnalysisGenomics and Chromatin DynamicsBacterial Genetics and Biotechnology

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Transcription in Living Cells: Molecular Mechanisms of Bursting

Rodriguez, Joseph, Larson, Daniel R.·2020·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-011520-105250

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Abstract

Transcription in several organisms from certain bacteria to humans has been observed to be stochastic in nature: toggling between active and inactive states. Periods of active nascent RNA synthesis known as bursts represent individual gene activation events in which multiple polymerases are initiated. Therefore, bursting is the single locus illustration of both gene activation and repression. Although transcriptional bursting was originally observed decades ago, only recently have technological advances enabled the field to begin elucidating gene regulation at the single-locus level. In this review, we focus on how biochemical, genomic, and single-cell data describe the regulatory steps of transcriptional bursts.

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Authors: Rodriguez, J., & Larson, D. R.
Affiliations: National Institute of Environmental Health Sciences (US)
National Cancer Institute (US)
ORCID: Rodriguez, Joseph
Larson, Daniel R.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2020-06-20
Volume: 89
Issue: 1
Pages: 189-212
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-011520-105250
OpenAlex: W3013821085
Cited by: 224
References: 161
Citations by year: 2026: 19 · 2025: 32 · 2024: 50 · 2023: 38 · 2022: 29 · 2021: 42 · 2020: 14
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: transcriptional bursting, stochastic gene expression, gene activation, gene repression, RNA polymerase, single-cell transcriptomics, transcriptional noise
MeSH terms: Animals, Chromatin, DNA, Eukaryotic Cells, Gene Expression Regulation, Histones, Humans, RNA Polymerase II, RNA, Messenger, Stochastic Processes, Transcription, Genetic, Molecular Probes, Molecular Probe Techniques, Genome, Genetic Loci, Single-Cell Analysis

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Transcription in Living Cells: Molecular Mechanisms of Bursting

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