The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis
Open accessAbstract
Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl diphosphate. Two of the most important discoveries in isoprenoid biosynthetic studies in recent years are the elucidation of a second isoprenoid biosynthetic pathway [the methylerythritol phosphate (MEP) pathway] and a modified mevalonic acid (MVA) pathway. In this review, we summarize mechanistic insights on the MEP pathway enzymes. Because many isoprenoids have important biological activities, the need to produce them in sufficient quantities for downstream research efforts or commercial application is apparent. Recent advances in both MVA and MEP pathway–based synthetic biology are also illustrated by reviewing the landmark work of artemisinic acid and taxadien-5α-ol production through microbial fermentations.
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Cited by
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
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Microalgae as a source of carotenoids in foods, obstacles and solutions
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Metadata
- Authors
- Zhao, L., Chang, W.-C., Xiao, Y., Liu, H.-W., & Liu, P.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2013-06-02
- Volume
- 82
- Issue
- 1
- Pages
- 497-530
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2135342375
- Cited by
- 353
- References
- 136
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, L., Chang, W.-C., Xiao, Y., Liu, H.-W., & Liu, P. (2013). Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-052010-100934
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