Microalgae as a source of carotenoids in foods, obstacles and solutions
Open accessAbstract
Recently, microalgae have attracted attention as a natural source of healthier bioactive molecules, especially carotenoids, because human bodies lack the ability to synthesize them, and their intake is necessary for human nutrition. Microalgae can produce various classes of these natural products, distinguished by their health benefits. In food sectors, microalgae are available as whole cells or as a source for extracting a specific carotenoid. This review summarizes recent knowledge of the biosynthesis pathway and the factors affecting carotenoid content, as well as strategies for increasing microalgae synthesis of various carotenoids. New uses of carotenoid-rich microalgae in food are highlighted, along with the main challenges and suggested solutions for using microalgal-carotenoids in the foodstuff. Carotenoids, particularly β-carotene and astaxanthin, face significant challenges in terms of bioavailability and stability when included in foods. Although many solutions were proposed, more research is required to determine the stability of other carotenoids under various food processing techniques. Furthermore, future studies should focus on improving bioavailability and accessibility after digestion in order to benefit from all added carotenoids. Modern technology and a fast-paced lifestyle necessitate the inclusion and acceptance of microalgal carotenoids, particularly for the most vulnerable populations, children, and pregnant women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intrinsic and extrinsic factors compromise nutrient release and absorption, including robust cell wall structures, chemical and physical instability of bioactives, and interactions with food matrix components.
“Several intrinsic and extrinsic factors compromise nutrient release and absorption, including the robust cell wall structures that restrict the liberation of intracellular nutrients, the chemical and physical instability of bioactives during processing and gastrointestinal digestion, and interactions with other food matrix components that hinder nutrient solubility and uptake [91,92].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [91]
The 'Obstacles and solutions' section (page unavailable) says microalgal cell walls impede nutrient access during digestion, dietary fiber reduces carotenoid absorption, and oxidation or prolonged boiling can reduce carotenoid availability. It does not establish the broader claim that bioactives undergo chemical and physical instability during gastrointestinal digestion; its discussion is chiefly about carotenoids rather than nutrients generally. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works
Chen, C.-Y., Yeh, K.-L., Aisyah, R., Lee, D.-J., & Chang, J.-S. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.159 · Cited by 1,860 · see citing works
Harvesting techniques applied to microalgae: A review
Barros, A. I., Gonçalves, A. L., Simões, M., & Pires, J. C. M. (2015) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2014.09.037 · Cited by 1,015 · see citing works
HOW MANY SPECIES OF ALGAE ARE THERE?
Guiry, M. D. (2012) · Journal of Phycology · doi:10.1111/j.1529-8817.2012.01222.x · Cited by 1,002 · see citing works
Handbook of Microalgal Culture: Applied Phycology and Biotechnology
(2013) · doi:10.1002/9781118567166 · Cited by 979 · see citing works
Microalgae Metabolites: A Rich Source for Food and Medicine
Sathasivam, R., Radhakrishnan, R., Hashem, A., & Abd_Allah, E. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.003 · Cited by 872 · see citing works
Carotenoid extraction methods: A review of recent developments
Saini, R. K., & Keum, Y.-S. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.099 · Cited by 857 · see citing works
Carotenoids in Algae: Distributions, Biosyntheses and Functions
Takaichi, S. (2011) · Marine Drugs · doi:10.3390/md9061101 · Cited by 809 · see citing works
Saini, R. K., Nile, S. H., & Park, S. W. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.047 · Cited by 758 · see citing works
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 727 · see citing works
Microalgae for High-Value Products Towards Human Health and Nutrition
Barkia, I., Saari, N., & Manning, S. R. (2019) · Marine Drugs · doi:10.3390/md17050304 · Cited by 719 · see citing works
Microalgae as versatile cellular factories for valued products
Koller, M., Muhr, A., & Braunegg, G. (2014) · Algal Research · doi:10.1016/j.algal.2014.09.002 · Cited by 639 · see citing works
Microalgae as sources of carotenoids
Guedes, A. C., Amaro, H. M., & Malcata, F. X. (2011) · Marine Drugs · doi:10.3390/md9040625 · Cited by 639 · see citing works
Techno-economic evaluation of microalgae harvesting and dewatering systems
Fasaei, F., Bitter, J. H., Slegers, P. M., & van Boxtel, A. J. B. (2018) · Algal Research · doi:10.1016/j.algal.2017.11.038 · Cited by 621 · see citing works
Dietary Sources of Lutein and Zeaxanthin Carotenoids and Their Role in Eye Health
Abdel‐Aal, E. M., Akhtar, H., Zaheer, K., & Ali, R. (2013) · Nutrients · doi:10.3390/nu5041169 · Cited by 555 · see citing works
Biotechnological production of carotenoids by yeasts: an overview
Mata-Gómez, L. C., Montañez, J., Méndez‐Zavala, A., & Aguilar, C. N. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-12 · Cited by 511 · see citing works
Maltsev, Y., Maltseva, K., Kulikovskiy, M., & Maltseva, S. (2021) · Biology · doi:10.3390/biology10101060 · Cited by 511 · see citing works
Sathasivam, R., & Ki, J. (2018) · Marine Drugs · doi:10.3390/md16010026 · Cited by 481 · see citing works
Functional Beverages: The Emerging Side of Functional Foods
Corbo, M. R., Bevilacqua, A., Petruzzi, L., Casanova, F. P., & Sinigaglia, M. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12109 · Cited by 462 · see citing works
Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction
Novoveská, L., Ross, M. E., Stanley, M. S., Pradelles, R., Wasiolek, V., & Sassi, J.-F. (2019) · Marine Drugs · doi:10.3390/md17110640 · Cited by 462 · see citing works
Heterotrophic cultivation of microalgae for pigment production: A review
Hu, J., Nagarajan, D., Zhang, Q., Chang, J., & Lee, D. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.09.009 · Cited by 456 · see citing works
Bhatnagar, A., Chinnasamy, S., Singh, M., & Das, K. C. (2011) · Applied Energy · doi:10.1016/j.apenergy.2010.12.064 · Cited by 451 · see citing works
Panis, G., & Carreón, J. R. (2016) · Algal Research · doi:10.1016/j.algal.2016.06.007 · Cited by 444 · see citing works
Handbook of Microalgal Mass Culture (1986)
(2017) · CRC Press eBooks · doi:10.1201/9780203712405 · Cited by 420 · see citing works
Camacho, F., Macedo, A., & Malcata, F. (2019) · Marine Drugs · doi:10.3390/md17060312 · Cited by 409 · see citing works
Biotechnological production of lutein and its applications
Fernández-Sevilla, J. M., Acién, F. G., & Grima, E. M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2420-y · Cited by 406 · see citing works
Availability and Utilization of Pigments from Microalgae
Begum, H., Yusoff, F. M., Banerjee, S., Khatoon, H., & Shariff, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.764841 · Cited by 380 · see citing works
Industrial potential of carotenoid pigments from microalgae: Current trends and future prospects
Ambati, R. R., Gogisetty, D., Aswathanarayana, R. G., Ravi, S., Bikkina, P. N., Bo, L., & Yuepeng, S. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1432561 · Cited by 372 · see citing works
Olaizola, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008159127672 · Cited by 359 · see citing works
Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis
Zhao, L., Chang, W., Xiao, Y., Liu, H., & Liu, P. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052010-100934 · Cited by 356 · see citing works
Meléndez‐Martínez, A. J., Mandić, A., Bantis, F., Böhm, V., Borge, G. I. A., Brnčić, M., Bysted, A., Cano, M. P., Dias, M. D. G., Elgersma, A., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867959 · Cited by 351 · see citing works
Lipid recovery from wet oleaginous microbial biomass for biofuel production: A critical review
Dong, T., Knoshaug, E. P., Pienkos, P. T., & Laurens, L. M. L. (2016) · Applied Energy · doi:10.1016/j.apenergy.2016.06.002 · Cited by 349 · see citing works
Microalgal cell disruption for biofuel development
Halim, R., Harun, R., Danquah, M. K., & Webley, P. A. (2011) · Applied Energy · doi:10.1016/j.apenergy.2011.08.048 · Cited by 347 · see citing works
Suparmaniam, U., Lam, M. K., Uemura, Y., Lim, J. W., Lee, K. T., & Shuit, S. H. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.109361 · Cited by 344 · see citing works
<i>Dunaliella</i>biotechnology: methods and applications
Hosseini Tafreshi, A., & Shariati, M. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04153.x · Cited by 343 · see citing works
Cell-wall disruption and lipid/astaxanthin extraction from microalgae: Chlorella and Haematococcus
Kim, D.-Y., Vijayan, D., Praveenkumar, R., Han, J., Lee, K., Park, J., Chang, W.-S., Lee, J., & Oh, Y. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.08.107 · Cited by 334 · see citing works
Acién, F. G., Gómez-Serrano, C., Morales-Amaral, M. M., Fernández-Sevilla, J. M., & Molina-Grima, E. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7835-7 · Cited by 333 · see citing works
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323 · see citing works
Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis
Khoo, K. S., Lee, S. Y., Ooi, C. W., Fu, X., Miao, X., Ling, T. C., & Show, P. L. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121606 · Cited by 318 · see citing works
Selective extraction from microalgae Nannochloropsis sp. using different methods of cell disruption
Grimi, N., Dubois, A., Marchal, L., Jubeau, S., Lebovka, N., & Vorobiev, E. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.12.011 · Cited by 314 · see citing works
Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration—Neurodegenerative Disease
Mrowicka, M., Mrowicki, J., Kucharska, E., & Majsterek, I. (2022) · Nutrients · doi:10.3390/nu14040827 · Cited by 299 · see citing works
Saini, R. K., Parchuri, P., Lokesh, V., Shang, X., Shin, J., Keum, Y., & Lee, J. (2022) · Antioxidants · doi:10.3390/antiox11040795 · Cited by 295 · see citing works
Gallego, R., Bueno, M., & Herrero, M. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.04.030 · Cited by 293 · see citing works
Concepts and studies on lipid and pigments of microalgae: A review
D’Alessandro, E. B., & Antoniosi Filho, N. R. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.162 · Cited by 289 · see citing works
Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M. G. J., de Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22725 · Cited by 277 · see citing works
Overview of carotenoid bioavailability determinants: From dietary factors to host genetic variations
Desmarchelier, C., & Borel, P. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.03.002 · Cited by 277 · see citing works
Mohan, S. V., Rohit, M. V., Chiranjeevi, P., Chandra, R., & Navaneeth, B. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.10.056 · Cited by 276 · see citing works
Fradique, M., Batista, A. P., Nunes, M. C., Gouveia, L., Bandarra, N. M., & Raymundo, A. (2010) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3999 · Cited by 274 · see citing works
Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark
Ip, P.-F., & Chen, F. (2005) · Process Biochemistry · doi:10.1016/j.procbio.2004.01.039 · Cited by 270 · see citing works
Sánchez, M. D. M., Mantell, C., RODRIGUEZ, M., MARTINEZDELAOSSA, E., Lubián, L. M., & Montero, O. (2008) · Talanta · doi:10.1016/j.talanta.2008.07.032 · Cited by 267 · see citing works
Sánchez, J. F., Fernández, J. M., Acién, F. G., Rueda, A., Pérez-Parra, J., & Molina, E. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.01.004 · Cited by 264 · see citing works
Effect of Light Intensity and Quality on Growth Rate and Composition of Chlorella vulgaris
Metsoviti, M. N., Papapolymerou, G., Karapanagiotidis, I. Τ., & Katsoulas, N. (2019) · Plants · doi:10.3390/plants9010031 · Cited by 262 · see citing works
Cordero, B. F., Obraztsova, I., Couso, I., León, R., Vargas, M. A., & Rodrı́guez, H. (2011) · Marine Drugs · doi:10.3390/md9091607 · Cited by 259 · see citing works
García-González, M., Moreno, J., Manzano, J. C., Florencio, F. J., & Guerrero, M. G. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.07.010 · Cited by 258 · see citing works
Production of carotenoids by microalgae: achievements and challenges
Varela, J. C. S., Pereira, H., Vilà, M., & León, R. (2015) · Photosynthesis Research · doi:10.1007/s11120-015-0149-2 · Cited by 252 · see citing works
Shi, X., Zhang, X., & Chen, F. (2000) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(00)00208-8 · Cited by 251 · see citing works
Fucoxanthin—An Antibacterial Carotenoid
Karpiński, T. M. M., & Adamczak, A. (2019) · Antioxidants · doi:10.3390/antiox8080239 · Cited by 236 · see citing works
Chemistry, Occurrence, Properties, Applications, and Encapsulation of Carotenoids—A Review
González-Peña, M. A., Ortega-Regules, A. E., de Parrodi, C. A., & Lozada‐Ramírez, J. D. (2023) · Plants · doi:10.3390/plants12020313 · Cited by 233 · see citing works
Supercritical fluid extraction of carotenoids and chlorophyll a from Nannochloropsis gaditana
Sánchez, M. D. M., Mantell, C., Rodríguez, M., de la Ossa, E. J. M., Lubián, L. M., & Montero, O. (2004) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2004.03.021 · Cited by 232 · see citing works
The potentials and challenges of using microalgae as an ingredient to produce meat analogues
Fu, Y., Chen, T., Chen, S. H. Y., Liu, B., Sun, P., Sun, H., & Chen, F. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.050 · Cited by 229 · see citing works
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases
Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13085128 · Cited by 228 · see citing works
Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
Mularczyk, M., Michalak, I., & Marycz, K. (2020) · Marine Drugs · doi:10.3390/md18090459 · Cited by 228 · see citing works
Cultivation of Microalgae for Biodiesel Production: A Review on Upstream and Downstream Processing
Tan, X. B., Lam, M. K., Uemura, Y., Lim, J. W., Wong, C. Y., & Lee, K. T. (2018) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2017.08.010 · Cited by 224 · see citing works
The Impact of Microalgae in Food Science and Technology
Matos, Â. P. (2017) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-017-3050-7 · Cited by 222 · see citing works
Biomass recovery and lipid extraction processes for microalgae biofuels production: A review
Menegazzo, M. L., & Fonseca, G. G. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.01.064 · Cited by 217 · see citing works
β-Carotene—properties and production methods
Bogacz-Radomska, L., & Harasym, J. (2018) · Food Quality and Safety · doi:10.1093/fqsafe/fyy004 · Cited by 216 · see citing works
Ho, S., Chan, M.-C., Liu, C.-C., Chen, C., Lee, W.-L., Lee, D., & Chang, J. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.11.031 · Cited by 211 · see citing works
Supercritical CO2 extraction of carotenoids and other lipids from Chlorella vulgaris
Mendes, R. L., Fernandes, H. L., Coelho, J. P., Reis, E. C., Cabral, J. M. S., Novais, J. M., & Palavra, A. M. F. (1995) · Food Chemistry · doi:10.1016/0308-8146(95)95794-7 · Cited by 211 · see citing works
Foo, S. C., Yusoff, F. M., Ismail, M., Basri, M., Yau, S. K., Khong, N. M. H., Chan, K. W., & Ebrahimi, M. M. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.11.026 · Cited by 209 · see citing works
Microalgal carotenoids: beneficial effects and potential in human health
Zhang, J., Sun, Z., Sun, P., Chen, T., & Chen, F. (2013) · Food & Function · doi:10.1039/c3fo60607d · Cited by 205 · see citing works
Viuda‐Martos, M., Sanchez-Zapata, E., Sayas‐Barberá, E., Sendra, E., Pérez‐Álvarez, J. Á., & Fernández‐López, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.623799 · Cited by 204 · see citing works
Potential of Microalgae Carotenoids for Industrial Application
Cezare-Gomes, E. A., Mejia-da-Silva, L. D. C., Mora, L. S. P., Matsudo, M. C., Ferreira‐Camargo, L. S., Singh, A. K., & de Carvalho, J. C. M. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-02945-4 · Cited by 198 · see citing works
Factors responsible for astaxanthin formation in the Chlorophyte Haematococcus pluvialis
Harker, M., Tsavalos, A. J., & Young, A. J. (1996) · Bioresource Technology · doi:10.1016/0960-8524(95)00002-x · Cited by 195 · see citing works
Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies
Ren, Y., Sun, H., Deng, J., Huang, J., & Chen, F. (2021) · Marine Drugs · doi:10.3390/md19120713 · Cited by 193 · see citing works
Cordero, B. F., Couso, I., León, R., Rodrı́guez, H., & Vargas, M. A. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3262-y · Cited by 190 · see citing works
Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms
Torregrosa‐Crespo, J., Montero, Z., Fuentes, J. L., García-Galbis, M. R., Garbayo, I., Vı́lchez, C., & Martínez‐Espinosa, R. M. (2018) · Marine Drugs · doi:10.3390/md16060203 · Cited by 187 · see citing works
Ip, P.-F., Wong, K.-H., & Chen, F. (2004) · Process Biochemistry · doi:10.1016/j.procbio.2003.08.003 · Cited by 184 · see citing works
Dominguez-Bocanegra, A. R., Legarreta, I. G., Martı́nez-Jerónimo, F., & Tomasini-Campocosio, A. (2003) · Bioresource Technology · doi:10.1016/j.biortech.2003.04.001 · Cited by 184 · see citing works
Valuable pigments from microalgae: phycobiliproteins, primary carotenoids, and fucoxanthin
Zittelli, G. C., Lauceri, R., Faraloni, C., Benavides, A. M. S., & Torzillo, G. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00407-3 · Cited by 184 · see citing works
Research progress on extraction, biological activities and delivery systems of natural astaxanthin
Zhao, T., Yan, X., Sun, L., Yang, T., Hu, X., He, Z., Liu, F., & Liu, X. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.07.014 · Cited by 183 · see citing works
Abe, K., Hattori, H., & Hirano, M. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2005.10.026 · Cited by 182 · see citing works
Beheshtipour, H., Mortazavian, A. M., Mohammadi, R., Sohrabvandi, S., & Khosravi‐Darani, K. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12004 · Cited by 178 · see citing works
Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90261-r · Cited by 178 · see citing works
Grünewald, K., Hirschberg, J., & Hagen, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006400200 · Cited by 175 · see citing works
Toti, E., Chen, O., Palmery, M., Villaño, D., & Peluso, I. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4637861 · Cited by 171 · see citing works
Astaxanthin: How much is too much? A safety review
Brendler, T., & Williamson, E. M. (2019) · Phytotherapy Research · doi:10.1002/ptr.6514 · Cited by 171 · see citing works
Liu, W., Wang, J., McClements, D. J., & Zou, L. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.11.046 · Cited by 167 · see citing works
Chemicals to enhance microalgal growth and accumulation of high-value bioproducts
Yu, X., Chen, L., & Zhang, W. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00056 · Cited by 166 · see citing works
Sanzo, G. D., Mehariya, S., Martino, M., Larocca, V., Casella, P., Chianese, S., Musmarra, D., Balducchi, R., & Molino, A. (2018) · Marine Drugs · doi:10.3390/md16090334 · Cited by 166 · see citing works
Molasses-based growth and production of oil and astaxanthin by Chlorella zofingiensis
Liu, J., Huang, J., Jiang, Y., & Chen, F. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.12.047 · Cited by 164 · see citing works
Borowitzka, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811405-6.00003-7 · Cited by 163 · see citing works
Nagarajan, D., Chang, J., & Lee, D. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122871 · Cited by 163 · see citing works
Cerón-García, M. C., Campos, I., Sánchez, J. F., Acién, F. G., Molina, E., & Fernández-Sevilla, J. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8025875 · Cited by 161 · see citing works
Trovão, M., Schüler, L., Machado, A., Bombo, G., Navalho, S., Barros, A. I. R. N. A., Pereira, H., Silva, J., Freitas, F., & Varela, J. C. S. (2022) · Marine Drugs · doi:10.3390/md20070440 · Cited by 160 · see citing works
Gouveia, L., Raymundo, A., Batista, A. P., de Sousa, I. M. N., & Empis, J. (2005) · European Food Research and Technology · doi:10.1007/s00217-005-0105-z · Cited by 158 · see citing works
Diversity and Ecology of Eukaryotic Marine Phytoplankton
Not, F., Siano, R., Kooistra, W. H. C. F., Simon, N., Vaulot, D., & Probert, I. (2012) · Advances in botanical research · doi:10.1016/b978-0-12-391499-6.00001-3 · Cited by 157 · see citing works
Potential and Challenges of Improving Photosynthesis in Algae
Vecchi, V., Barera, S., Bassi, R., & Dall’Osto, L. (2020) · Plants · doi:10.3390/plants9010067 · Cited by 157 · see citing works
Emerging Trends in Genetic Engineering of Microalgae for Commercial Applications
Grama, S. B., Liu, Z., & Li, J. (2022) · Marine Drugs · doi:10.3390/md20050285 · Cited by 157 · see citing works
Molino, A., Mehariya, S., Iovine, A., Larocca, V., Di Sanzo, G., Martino, M., Casella, P., Chianese, S., & Musmarra, D. (2018) · Marine Drugs · doi:10.3390/md16110432 · Cited by 155 · see citing works
Lutein production by Muriellopsis sp. in an outdoor tubular photobioreactor
Campo, J. A. D., Rodrı́guez, H., Moreno, J., Vargas, M. A., Rivas, J., & Guerrero, M. G. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00380-1 · Cited by 150 · see citing works
Martínez-Álvarez, Ó., Calvo, M. M., & Gómez-Estaca, J. (2020) · Marine Drugs · doi:10.3390/md18080406 · Cited by 148 · see citing works
Huang, W., Lin, Y., He, M., Gong, Y., & Huang, J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05400 · Cited by 147 · see citing works
Membrane applications for microalgae cultivation and harvesting: a review
Drexler, I. L. C., & Yeh, D. H. (2014) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-014-9350-6 · Cited by 141 · see citing works
Campenni’, L., Nobre, B. P., Santos, C. A., Oliveira, A. C., Aires-Barros, M. R., Palavra, A. M. F., & Gouveia, L. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4570-6 · Cited by 141 · see citing works
Outdoor cultivation of lutein-rich cells of Muriellopsis sp. in open ponds
Blanco, A. M., Moreno, J., Del Campo, J. A., Rivas, J., & Guerrero, M. G. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0598-9 · Cited by 140 · see citing works
Liu, J., Sun, Z., Gerken, H. G., Huang, J., Jiang, Y., & Chen, F. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5593-y · Cited by 139 · see citing works
Ummalyma, S. B., Sirohi, R., Udayan, A., Yadav, P., Raj, A., Sim, S. J., & Pandey, A. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09814-3 · Cited by 138 · see citing works
Gómez‐Estaca, J., Comunian, T. A., Montero, P., Furtado, R. F., & Fávaro-Trindade, C. S. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.05.005 · Cited by 134 · see citing works
Impact of Chlorella vulgaris on the rheology of wheat flour dough and bread texture
Graça, C., Fradinho, P., de Sousa, I. M. N., & Raymundo, A. (2017) · LWT · doi:10.1016/j.lwt.2017.11.024 · Cited by 132 · see citing works
Hossain, A. K. M. M., Brennan, M. A., Mason, S. L., Guo, X., Zeng, X. A., & Brennan, C. S. (2017) · Foods · doi:10.3390/foods6080057 · Cited by 131 · see citing works
Barsanti, L. A., & Gualtieri, P. (2014) · CRC Press eBooks · doi:10.1201/b16544 · Cited by 131 · see citing works
Luengo, E., Martínez, J. M., Bordetas, A., Álvarez, I., & Raso, J. (2015) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2015.02.012 · Cited by 130 · see citing works
Production of carotenoids from microalgae cultivated using agroindustrial wastes
Rodrigues, D. B., Flores, É. M. M., Barin, J. S., Mercadante, A. Z., Lopes, E. J., & Zepka, L. Q. (2014) · Food Research International · doi:10.1016/j.foodres.2014.06.037 · Cited by 130 · see citing works
Eilers, U., Bikoulis, A., Breitenbach, J., Büchel, C., & Sandmann, G. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0583-8 · Cited by 127 · see citing works
Functional biscuits with PUFA‐ω3 from <i>Isochrysis galbana</i>
Gouveia, L., Coutinho, C., Mendonça, E., Batista, A. P., Sousa, I., Bandarra, N. M., & Raymundo, A. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3166 · Cited by 126 · see citing works
Gómez‐Loredo, A., Benavides, J., & Rito‐Palomares, M. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0635-0 · Cited by 126 · see citing works
Pelah, D., Sintov, A., & Cohen, E. (2004) · World Journal of Microbiology and Biotechnology · doi:10.1023/b:wibi.0000040398.93103.21 · Cited by 123 · see citing works
HOŞOĞLU, M. İ. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.08.052 · Cited by 123 · see citing works
Le Goff, M., Le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., & Ulmann, L. (2019) · Biochimie · doi:10.1016/j.biochi.2019.09.012 · Cited by 123 · see citing works
Fucoxanthin production by heterokont microalgae
Petrushkina, M., Gusev, E., Sorokin, B., Zotko, N., Mamaeva, A. S., Filimonova, A., Kulikovskiy, M. S., Maltsev, Y., Yampolsky, I. V., Гугля, Е. Б., et al. (2017) · Algal Research · doi:10.1016/j.algal.2017.03.016 · Cited by 122 · see citing works
Pogorzelska-Nowicka, E., Godziszewska, J., Brodowska, M., & Wierzbicka, A. (2017) · Meat Science · doi:10.1016/j.meatsci.2017.09.002 · Cited by 122 · see citing works
Singh, D. P., Khattar, J. S., Rajput, A., Chaudhary, R., & Singh, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221930 · Cited by 120 · see citing works
Euglena as a potential natural source of value-added metabolites. A review
Kottuparambil, S., Thankamony, R. L., & Agusti, S. (2019) · Algal Research · doi:10.1016/j.algal.2018.11.024 · Cited by 117 · see citing works
Production, extraction and stabilization of lutein from microalga Chlorella sorokiniana MB-1
Chen, C.-Y., Jesisca, Hsieh, C., Lee, D.-J., Chang, C.-H., & Chang, J.-S. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2015.10.071 · Cited by 116 · see citing works
Medeiros, A. K. D. O. C., Gomes, C. D. C., Amaral, M. L. Q. D. A., de Medeiros, L. D. G., Medeiros, I., Porto, D. L., Aragão, C. F. S., Maciel, B. L. L., Morais, A. H. D. A., & Passos, T. S. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.07.099 · Cited by 116 · see citing works
Evolutionary Patterns of Thylakoid Architecture in Cyanobacteria
Mareš, J., Strunecký, O., Bučinská, L., & Wiedermannová, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00277 · Cited by 116 · see citing works
Li, S., Ji, L., Shi, Q., Wu, H., & Fan, J. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122048 · Cited by 113 · see citing works
Rodrigues, E., Mariutti, L. R. B., Chisté, R. C., & Mercadante, A. Z. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.074 · Cited by 112 · see citing works
Xu, J., Wei, R., Jia, Z., & Song, R. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105436 · Cited by 112 · see citing works
Metabolic Engineering of Chlamydomonas reinhardtii for Enhanced β-Carotene and Lutein Production
Rathod, J. P., Vira, C., Lali, A. M., & Prakash, G. (2020) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03194-9 · Cited by 112 · see citing works
Enhanced Photosynthesis of Carotenoids in Microalgae Driven by Light-Harvesting Gold Nanoparticles
Li, X., Sun, H., Mao, X., Lao, Y., & Chen, F. (2020) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c00315 · Cited by 110 · see citing works
Farooq, W., Moon, M., Ryu, B.-G., Suh, W. I., Shrivastav, A., Park, M., Mishra, S. K., & Yang, J. (2015) · Algal Research · doi:10.1016/j.algal.2014.12.007 · Cited by 106 · see citing works
Occurrence and biosynthesis of carotenoids in phytoplankton
Huang, J. J., Lin, S., Xu, W., & Cheung, P. C. K. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.05.001 · Cited by 104 · see citing works
Bernaerts, T. M. M., Verstreken, H., Dejonghe, C., Gheysen, L., Foubert, I., Grauwet, T., & Van Loey, A. M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103770 · Cited by 102 · see citing works
Dong, S., Huang, Y. Q., Zhang, R., Wang, S., & Liu, Y. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/694305 · Cited by 100 · see citing works
In vitro bioaccesibility of lutein and zeaxanthin from the microalgae Scenedesmus almeriensis
Granado‐Lorencio, F., Herrero-Barbudo, C., Acién, F. G., Grima, E. M., Fernández-Sevilla, J. M., Pérez-Sacristán, B., & Blanco-Navarro, I. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.10.058 · Cited by 99 · see citing works
Liu, J., Gerken, H. G., Huang, J., & Chen, F. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.04.020 · Cited by 98 · see citing works
Mojaat, M., Pruvost, J., Foucault, A. P., & Legrand, J. (2007) · Biochemical Engineering Journal · doi:10.1016/j.bej.2007.09.009 · Cited by 98 · see citing works
Jaeschke, D. P., Rech, R., Marczak, L. D. F., & Mercali, G. D. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.11.107 · Cited by 96 · see citing works
Pohndorf, R. S., CAMARA, A. S., LARROSA, A. P. Q., Pinheiro, C. P., Strieder, M. M., & Pinto, L. A. D. A. (2016) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2016.06.020 · Cited by 95 · see citing works
Morowvat, M. H., & Ghasemi, Y. (2016) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2016.06.008 · Cited by 95 · see citing works
Extraction of value-added compounds from microalgae
Ventura, S. P. M., Nobre, B. P., Kaymak‐Ertekin, F., Hayes, M., García‐Vaquero, M., Vieira, F. A., Koç, M., Gouveia, L., Aires-Barros, M. R., & Palavra, A. M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-101023-5.00019-4 · Cited by 95 · see citing works
Marine Microalgae for Potential Lutein Production
Saha, S. K., Ermiş, H., & Murray, P. (2020) · Applied Sciences · doi:10.3390/app10186457 · Cited by 92 · see citing works
Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress
Wei, D., Chen, F., Chen, G., Zhang, X., Liu, L., & Zhang, H. (2008) · Science in China Series C: Life Sciences · doi:10.1007/s11427-008-0145-2 · Cited by 91 · see citing works
Liu, J., Sun, Z., Zhong, Y., Gerken, H. G., Huang, J., & Chen, F. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9974-x · Cited by 90 · see citing works
Cardoso, L. A. D. C., Karp, S. G., Vendruscolo, F., Kanno, K. Y. F., Zoz, L. I. C., & de Carvalho, J. C. (2017) · InTech eBooks · doi:10.5772/67725 · Cited by 90 · see citing works
Main Carotenoids Produced by Microorganisms
Martínez-Cámara, S., Ibáñez, A., Rubio, S., Barreiro, C., & Barredo, J. L. (2021) · Encyclopedia · doi:10.3390/encyclopedia1040093 · Cited by 90 · see citing works
İmamoğlu, E., Dalay, M. C., & Sukan, F. V. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.08.007 · Cited by 89 · see citing works
Algal Carotenoids: Chemistry, Sources, and Application
Mekinić, I. G., Šimat, V., Rathod, N. B., Hamed, I., & Čagalj, M. (2023) · Foods · doi:10.3390/foods12142768 · Cited by 89 · see citing works
Chlorella sorokiniana: A new alternative source of carotenoids and proteins for gluten-free bread
Diprat, A. B., Thys, R. C. S., Rodrigues, E., & Rech, R. (2020) · LWT · doi:10.1016/j.lwt.2020.109974 · Cited by 87 · see citing works
Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering
Wan, X., Zhou, X., Moncalián, G., Su, L. C., Chen, W., Zhu, H.-Z., Chen, D., Gong, Y., Huang, F., & Deng, Q. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101083 · Cited by 87 · see citing works
Stoll, L., Rech, R., Flôres, S. H., Nachtigall, S. M. B., & Rios, A. D. O. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2018.12.100 · Cited by 85 · see citing works
Determination of Volatile Organic Compounds in Selected Strains of Cyanobacteria
Milovanović, I., Mišan, A. Č., Simeunović, J. B., Blagojević, D., Škrobot, D., & Mandić, A. (2015) · Journal of Chemistry · doi:10.1155/2015/969542 · Cited by 82 · see citing works
Machado, F. R. S., Reis, D. F., Boschetto, D. L., Burkert, J. F. M., Ferreira, S. R. S., de Oliveira, J. V., & Burkert, C. A. V. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.01.007 · Cited by 82 · see citing works
Bassijeh, A., Ansari, S., & Hosseini, S. M. H. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109689 · Cited by 82 · see citing works
Passive cell disruption lipid extraction methods of microalgae for biofuel production – A review
Nagappan, S., Devendran, S., Tsai, P., Dinakaran, S., Dahms, H.-U., & Ponnusamy, V. K. (2019) · Fuel · doi:10.1016/j.fuel.2019.04.092 · Cited by 81 · see citing works
Rao, A. R., Ravishankar, G. A., & Sarada, R. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.07.009 · Cited by 80 · see citing works
Batista, A. P., Nunes, M. C., Fradinho, P., Gouveia, L., de Sousa, I. M. N., Raymundo, A., & Franco, J. M. (2011) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2011.05.044 · Cited by 80 · see citing works
Algal Pigments for Human Health and Cosmeceuticals
Chakdar, H., & Pabbi, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-444-63784-0.00009-6 · Cited by 80 · see citing works
Molino, A., Mehariya, S., Iovine, A., Casella, P., Marino, T., Karatza, D., Chianese, S., & Musmarra, D. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00415 · Cited by 80 · see citing works
Zhang, J., Jia, G., Wanbin, Z., Minghao, J., Wei, Y., Hao, J., Liu, X., Gan, Z., & Sun, A. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106280 · Cited by 80 · see citing works
Torzillo, G., & Chini Zittelli, G. (2015) · Algal Biorefineries · doi:10.1007/978-3-319-20200-6_5 · Cited by 79 · see citing works
Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets
Le, T., Knulst, A. C., & Röckmann, H. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.10.024 · Cited by 77 · see citing works
Chen, J.-H., Chen, C., & Chang, J. (2017) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2017.04.022 · Cited by 77 · see citing works
Goecke, F., Noda, J., Paliocha, M., & Gislerød, H. R. (2020) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-020-02897-0 · Cited by 77 · see citing works
Chen, J.-H., Chen, C., Hasunuma, T., Kondo, A., Chang, C., Ng, I., & Chang, J. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.01.041 · Cited by 76 · see citing works
What Do We Know about Antimicrobial Activity of Astaxanthin and Fucoxanthin?
Karpiński, T. M. M., Ożarowski, M., Alam, R., Łochyńska, M., & Stasiewicz, M. (2021) · Marine Drugs · doi:10.3390/md20010036 · Cited by 76 · see citing works
Park, H.-S., Kwak, M., Seo, J., Ju, J.-H., Heo, S.-Y., Park, S.-M., & Hong, W.-K. (2018) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-018-1963-7 · Cited by 73 · see citing works
Ma, R., Zhang, Z., Ho, S., Ruan, C., Li, J., Xie, Y., Shi, X., Liu, L., & Chen, J. (2020) · Algal Research · doi:10.1016/j.algal.2020.102119 · Cited by 73 · see citing works
Harvesting microalgal biomass and lipid extraction for potential biofuel production: A review
Japar, A. S., Takriff, M. S., & Yasin, N. H. M. (2016) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2016.12.016 · Cited by 72 · see citing works
Úbeda, B., Gálvez, J. A., Michel-Rodriguez, M., & Bartual, A. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.12.095 · Cited by 71 · see citing works
New insights into Chlorella vulgaris applications
Al-Hammadi, M. S., & Güngörmüşler, M. (2024) · Biotechnology and Bioengineering · doi:10.1002/bit.28666 · Cited by 68 · see citing works
Production of Single Cell Oils by Dinoflagellates
Wynn, J. P., Behrens, P., Sundararajan, A., Hansen, J., & Apt, K. E. (2010) · Elsevier eBooks · doi:10.1016/b978-1-893997-73-8.50010-4 · Cited by 67 · see citing works
Minyuk, G., Sidorov, R., & Solovchenko, A. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02060-0 · Cited by 67 · see citing works
Novel protocol optimized for microalgae lutein used as food additives
Low, K. L., Idris, A., & Yusof, N. M. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125631 · Cited by 66 · see citing works
Abdel‐Aal, E. M., Young, J. C., Akhtar, H., & Rabalski, I. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102400t · Cited by 64 · see citing works
Bioaccessibility, Bioavailability and Bioactivities of Carotenoids in Microalgae: A Review
Duan, X., Xie, C., Hill, D. R., Barrow, C. J., Dunshea, F. R., Martin, G. J. O., & Suleria, H. A. R. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2165095 · Cited by 64 · see citing works
Encapsulation of microalgal-based carotenoids: Recent advances in stability and food applications
Hamed, I., Moradi, M., Ezati, P., O’Higgins, L., Meléndez‐Martínez, A. J., Matas, R. F., Šimat, V., McClements, D. J., Jakobsen, A. N., & Lerfall, J. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.027 · Cited by 64 · see citing works
Microalgae: from staple foodstuff to avant-garde cuisine
Pérez-Lloréns, J. L. (2020) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2020.100221 · Cited by 61 · see citing works
Coulombier, N., Nicolau, E., Le Déan, L., Barthelemy, V., Schreiber, N., Brun, P., Lebouvier, N., & Jauffrais, T. (2020) · Marine Drugs · doi:10.3390/md18090453 · Cited by 61 · see citing works
Development of a Green Downstream Process for the Valorization of Porphyridium cruentum Biomass
Gallego, R., Martínez, M., Cifuentes, A., Ibáñez, E., & Herrero, M. (2019) · Molecules · doi:10.3390/molecules24081564 · Cited by 60 · see citing works
Mixotrophic cultivation of microalgae for carotenoid production
Liaqat, F., Khazi, M. I., Bahadar, A., He, L., Aslam, A., Liaquat, R., Agathos, S. N., & Li, J. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12700 · Cited by 60 · see citing works
Bonilla-Ahumada, F. D. J., Khandual, S., & Lugo-Cervantes, E. D. C. (2018) · Algal Research · doi:10.1016/j.algal.2018.10.006 · Cited by 59 · see citing works
Photoprotective Role of Neoxanthin in Plants and Algae
Giossi, C. E., Cartaxana, P., & Cruz, S. (2020) · Molecules · doi:10.3390/molecules25204617 · Cited by 58 · see citing works
Zou, X., Li, Y., Xu, K., Wen, H., Shen, Z., & Ren, X. (2018) · Algal Research · doi:10.1016/j.algal.2018.04.010 · Cited by 57 · see citing works
Development and Characterization of Astaxanthin-Containing Whey Protein-Based Nanoparticles
Zanoni, F., Vakarelova, M., & Zoccatelli, G. (2019) · Marine Drugs · doi:10.3390/md17110627 · Cited by 57 · see citing works
Are Cyanobacteria an Ancestor of Chloroplasts or Just One of the Gene Donors for Plants and Algae?
Sato, N. (2021) · Genes · doi:10.3390/genes12060823 · Cited by 57 · see citing works
Bioaccessibility of microalgae-based carotenoids and their association with the lipid matrix
Fernandes, A. S., do Nascimento, T. C., Pinheiro, P. N., Vendruscolo, R. G., Wagner, R. C., de Rosso, V. V., Lopes, E. J., & Zepka, L. Q. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110596 · Cited by 57 · see citing works
de Medeiros, V. P. B., Pimentel, T. C., Sant’Ana, A. S., & Magnani, M. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2020.10.014 · Cited by 55 · see citing works
Celi, C., Fino, D., & Savorani, F. (2022) · Bioresource Technology Reports · doi:10.1016/j.biteb.2022.101122 · Cited by 55 · see citing works
Vaquero, I., Ruiz‐Domínguez, M. C., Márquez, M., & Vı́lchez, C. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.01.016 · Cited by 54 · see citing works
Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides
Szabo, N. J., Matulka, R. A., & Chan, T. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.035 · Cited by 52 · see citing works
Production of stable food-grade microencapsulated astaxanthin by vibrating nozzle technology
Vakarelova, M., Zanoni, F., Lardo, P., Rossin, G., Mainente, F., Chignola, R., Menin, A., Rizzi, C., & Zoccatelli, G. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.10.085 · Cited by 51 · see citing works
Caporgno, M. P., Haberkorn, I., Böcker, L., & Mathys, A. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121476 · Cited by 50 · see citing works
Bio-refinery of Chlorella sorokiniana with pulsed electric field pre-treatment
Leonhardt, L., Käferböck, A., Smetana, S. M., de Vos, R., Toepfl, S., & Parniakov, O. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122743 · Cited by 50 · see citing works
Cuaresma, M., Casal, C., Forján, E., & Vı́lchez, C. (2010) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-010-0841-3 · Cited by 49 · see citing works
Wolf, L., Cummings, T., Müller, K., Reppke, M., Volkmar, M., & Weuster‐Botz, D. (2021) · Engineering in Life Sciences · doi:10.1002/elsc.202000044 · Cited by 49 · see citing works
Cell Disruption and Pressurized Liquid Extraction of Carotenoids from Microalgae
Taucher, J., & Baer, S. (2016) · Journal of Thermodynamics & Catalysis · doi:10.4172/2157-7544.1000158 · Cited by 48 · see citing works
Ho, C. W., Tan, W. S., Yap, W. B., Ling, T. C., & Tey, B. T. (2008) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-008-0020-9 · Cited by 46 · see citing works
dos Santos, A. M., Vieira, K. R., Sartori, R. B., dos Santos, A. M., Queiroz, M. I., Zepka, L. Q., & Lopes, E. J. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00012 · Cited by 45 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- Fay P (1992) Oxygen relations of nitrogen fixation in cyanobacteria. Microbiol Rev 56:340-373. https://doi.org/ 10.1128/mr.56.2.340-373 · DOI
- molecules24081564 · DOI
- foods12142768 · DOI
- plants12020313 · DOI
- molecules27082540 · DOI
- 0c00315 · DOI
- biology10101060 · DOI · Paper page
- antiox11040795 · DOI
- Sun H, Wang Y, He Y et al (2023) Microalgae-derived pigments for the food industry. Mar Drugs 21:82. https://doi.org/10. 3390/md210200820 · DOI
Cited by
Sorted by citations
Microalgae Bioactives for Functional Food Innovation and Health Promotion
Guil-Guerrero, J. L., & Prates, J. A. M. (2025) · Foods · doi:10.3390/foods14122122 · Cited by 47 · see citing works
“…the robust cell wall structures that restrict the liberation of intracellular nutrients, the chemical and physical instability of bioactives during processing and gastrointestinal digestion, and interactions with other food matrix components that hinder nutrient solubility and uptake [91,92].”
Algae as a sustainable feed resource: revolutionizing animal nutrition
Kazemi, M. (2025) · Aquaculture International · doi:10.1007/s10499-025-02195-2 · Cited by 12 · see citing works
Alqahtani, A., & Altoaimi, B. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1737889 · Cited by 7 · see citing works
Hanifa, N. M., Thevarajah, B., Nimarshana, P. H. V., Perera, M. A. R. C., Harshan, G. M. M., Abeyarathna, D. R. P., & Ariyadasa, T. U. (2025) · ACS ES&T Water · doi:10.1021/acsestwater.5c00897 · Cited by 5 · see citing works
Nur, S., Das, T., Acharjee, M. R., Newase, S., Haque, M. E., Afrin, S., Heema, H. P., Siddiki, A. Z., & Khatoon, H. (2025) · Journal of Phycology · doi:10.1111/jpy.70050 · Cited by 6 · see citing works
Advances in Synthetic Strategies for Microalgal Carotenoid Enhancement and Emerging Applications
Xu, P., Wang, Y., Luo, C., Xue, A., Du, H., & Chen, J. (2026) · Antioxidants · doi:10.3390/antiox15030359 · Cited by 4 · see citing works
Exploring major fruit coloring pigments: uncovering their biological significance and applications
Muhammad, N., Yang, Z., Wang, L., Liu, Z., Yang, M., & Liu, M. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250654 · Cited by 4 · see citing works
Fouad, M., El‐Fakharany, E. M., Mossad, M., Samy, M., & Alalm, M. G. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.107961 · Cited by 4 · see citing works
Sahadevan, S., Liow, M. Y., Mahendra, C. K., Ng, W. Z., Chan, E., Borhan, N., Yahya, L., Bakri, F. A. M., Japar, A. S., Chan, W., et al. (2026) · Phytochemistry Reviews · doi:10.1007/s11101-026-10247-5 · Cited by 2 · see citing works
Abreu, A. C., la Rosa, A. M.-D., Tristán, A. I., López‐Rosales, L., Salmerón, A. D. M., Sánchez‐Mirón, A., García-Camacho, F., Cerón-García, M. C., & Fernández, I. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c00160 · Cited by 1 · see citing works
Santana, J., de Mello, C., dos Santos, M. S., Bôas, R. N. V., Lucchetti, L., Mendes, M. F., & de Mendonça, H. V. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.117996 · Cited by 1 · see citing works
Multi-Omics Decoding of Fucoxanthin Biosynthesis: a Roadmap for Rational Synthetic Pathway Design
Sathishkumar, K., Ponnusamy, C. S., Santhoshkumar, M., Shanmugapriya, D., Parthasarathi, M., Kishore, K., Alam, M. M., & Al-Sehemi, A. G. (2026) · Waste and Biomass Valorization · doi:10.1007/s12649-026-03702-z · Cited by 1 · see citing works
Martins, V. F. R., Alves, A. J., Poças, M. D. F. T., Pintado, M., Morais, R. M. S. C., & Morais, A. M. M. B. (2025) · Phycology · doi:10.3390/phycology5030035
Perveen, I., Syed, Q., Abbas, N., Saleem, Y., Rehman, H. U., Rehman, M. U., Mazhar, S., Nawaz, S., Riaz, S., Mumtaz, A., et al. (2025) · Industrial Biotechnology · doi:10.1177/15509087251399209
New Insights for Microalgae Pigment Stability: Encapsulation Approaches
Pan-utai, W., & Thurakit, T. (2026) · Springer eBooks · doi:10.1007/978-3-032-05438-8_10
Non-Invasive Quantification of Microalgal Pigments Using RGB-Based Image AnalysisPreprint
Asgharnejad, H., Sarrafzadeh, M., Nazloo, E. K., & Bahri, P. A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6225538
Antioxidants from Algae: Treasured Natural Compounds for Human Benefits
Oyewusi, H. A., Adekilekun, H. A., Tijani, B. A., Oladipo, O. O., & Oyeyemi, B. F. (2026) · Reference series in phytochemistry · doi:10.1007/978-3-031-80866-1_18-1
Du, X., He, X., Wang, M., Wang, H., Lv, Q., Song, C., Liu, Y., Fan, Y., & Sui, F. (2026) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2026.109355
Sardrodi, M. M., Bandehagh, A., Hejazi, M. A., & Panahi, B. (2026) · BMC Plant Biology · doi:10.1186/s12870-026-08587-7
Development and Validation of LC-MS Analysis of Microalgal Pigments
Selvam, L., Mani, H., Sudharsan, M. S., Pandurangan, P., & Jaganathan, R. (2026) · Methods and protocols in food science · doi:10.1007/978-1-0716-5344-9_12
Algal Pigments: Chlorophylls, Carotenoids and Phycobilins as Health-Promoting Agents
Rani, M. H. E., Saranya, V. P., Rathnasamy, S., Kumar, S. R., & Aswini, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-22521-4_12
Optimizing culture conditions for micropropagation of Codium tomentosum
Sá, M. F., Duarte, A. M. G. D. D. A., Sousa-Pinto, I., & Marinho, G. S. (2026) · Journal of Applied Phycology · doi:10.1007/s10811-026-03944-3
Biofilm-assisted organic nitrogen uptake from chitin-containing cricket frass by Chlorella vulgaris
Kalbasi, A., Behin, J., & Bassi, A. (2026) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2026.109733
Environmental, Economic, and Sustainability Perspectives on Microbial Carotenoid Production
Kamikawachi, R. C., Contieri, L. S., & Mesquita, L. M. D. S. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837678297-00303
Alves, M. B. N., & Pereira, J. F. B. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837678297-00257
Microbial Carotenoid Market Trends and Regulatory Considerations
Tropea, A., Mondello, A., & Mondello, L. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837678297-00322
Health Benefits and Nutritional Significance of Microbial Carotenoids
Singhal, K., Sadukha, S., Chitania, K., Mehta, B., Nayak, M., Ghosh, A., & Dineshkumar, R. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837678297-00157
Šolto, T. J., Čagalj, M., & Šimat, V. (2026) · Sustainability · doi:10.3390/su18147433
Mokhtari, M., Mohammadi-Sichani, M., & Madani, M. (2026) · Biotechnology Letters · doi:10.1007/s10529-026-03767-9
Soliman, T. N., El-Dein, A. N., & Flefil, N. S. (2026) · Discover Food · doi:10.1007/s44187-026-01097-3
Park, S., Kim, G., Song, Y., Tian, C., Baek, C., Cho, Y., Kim, J. W., Jin, E., & Cho, S. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c02572
Antioxidant Compounds in Microalgae and Cyanobacteria: A Sustainable Source of Bioactive Molecules
Gómez‐Villegas, P., Díaz‐Santos, E., Rengel, R., Molina-Márquez, A., Rodríguez-González, J. M., Vigara, J., León, R., & Léon-Vaz, A. (2026) · Marine Drugs · doi:10.3390/md24080288
Mostafa, H. S. (2026) · LWT · doi:10.1016/j.lwt.2026.119921
Self-citationKossalbayev, B. D., Sadvakasova, A. K., Sandybayeva, S. K., Zaletova, D. E., & ZAIYR, E. M. (2026) · Photosynthetica · doi:10.32615/ps.2026.022
Das, T., Haque, M. E., Acharjee, M. R., Nur, S., Newase, S., Mustaquim, S., Islam, S. M. R., Minhaz, T. M., & Khatoon, H. (2026) · International Journal of Energy Research · doi:10.1155/er/8207111
Shruthy, N. S., Dong, C.-D., Chen, Y.-T., Hsieh, S.-L., Singhania, R. R., & Patel, A. K. (2026) · Bioresources and Bioprocessing · doi:10.1186/s40643-026-01136-y
- Authors
- Mostafa, H. S., & Hashem, M. M.
- Affiliations
- Cairo University (EG)
- Assiut University (EG)
- Corresponding author
- Mostafa, Heba Sayed
- Hashem, Marwa Mahmoud
- Venue
- Phytochemistry Reviews
- Published
- 2024-11-28
- Volume
- 24
- Issue
- 5
- Pages
- 4295-4337
- ISSN
- 1568-7767 (ISSN-L)
- 1572-980X
- OpenAlex
- W4404821446
- Cited by
- 36
- References
- 264
- Citations by year
- 2026: 26 · 2025: 10
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Phytochemistry Reviews (publishedVersion, cc-by)
- Funders
- Cairo University
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- microalgae, carotenoids, beta-carotene, astaxanthin, carotenoid biosynthesis, carotenoid bioavailability, carotenoid stability, food processing, health benefits
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review