The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Mechanisms of Methicillin Resistance in Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), with significantly lower affinity for β-lactams. This resistance allows cell-wall biosynthesis, the target of β-lactams, to continue even in the presence of typically inhibitory concentrations of antibiotic. PBP2a is encoded by the mecA gene, which is carried on a distinct mobile genetic element (SCCmec), the expression of which is controlled through a proteolytic signal transduction pathway comprising a sensor protein (MecR1) and a repressor (MecI). Many of the molecular and biochemical mechanisms underlying methicillin resistance in S. aureus have been elucidated, including regulatory events and the structure of key proteins. Here we review recent advances in this area.
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Waves of resistance: Staphylococcus aureus in the antibiotic era
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"Celbenin" - resistant Staphylococci
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The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
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Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat
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Cited by
Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, D., & Ingmer, H. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0057-2018 · Cited by 490
Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review
Teow, S.-Y., Liew, K., Ali, S. A., Khoo, A. S.-B., & Peh, S.-C. (2016) · Journal of Tropical Medicine · doi:10.1155/2016/2853045 · Cited by 328
Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 266
Metadata
- Authors
- Peacock, S. J., & Paterson, G. K.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2015-06-02
- Volume
- 84
- Issue
- 1
- Pages
- 577-601
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2130462828
- Cited by
- 656
- References
- 114
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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