The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Structural Biology of the Major Facilitator Superfamily Transporters
Abstract
The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of physiological processes. MFS proteins transport a broad spectrum of ions and solutes across membranes via facilitated diffusion, symport, or antiport. In recent years, remarkable advances in understanding the structural biology of the MFS transporters have been made. This article reviews the history, classification, and general features of the MFS proteins; summarizes recent structural progress with a focus on the sugar porter family transporters exemplified by GLUT1; and discusses the molecular mechanisms of substrate binding, alternating access, and cotransport coupling.
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Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
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Metadata
- Authors
- Yan, N.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2015-06-22
- Volume
- 44
- Issue
- 1
- Pages
- 257-283
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W1932059283
- Cited by
- 450
- References
- 118
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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