The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
Open accessAbstract
The concentration of glucose in plasma is held within narrow limits (4-10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine. Three membrane proteins are responsible for glucose reabsorption from the glomerular filtrate in the proximal tubule: sodium-glucose cotransporters SGLT1 and SGLT2, in the apical membrane, and GLUT2, a uniporter in the basolateral membrane. 'Knockout' of these transporters in mice and men results in the excretion of filtered glucose in the urine. In humans, intravenous injection of the plant glucoside phlorizin also results in excretion of the full filtered glucose load. This outcome and the finding that, in an animal model, phlorizin reversed the symptoms of diabetes, has stimulated the development and successful introduction of SGLT2 inhibitors, gliflozins, in the treatment of type 2 diabetes mellitus. Here we summarise the current state of our knowledge about the physiology of renal glucose handling and provide background to the development of SGLT2 inhibitors for type 2 diabetes treatment.
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Cites
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SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects
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SGLT2 Inhibitor–Induced Sympathoinhibition
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Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: A Clinician’s Guide
Simes, B. C., & MacGregor, G. G. (2019) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s212003 · Cited by 103
Obesity and the kidney: mechanistic links and therapeutic advances
Yau, K., Kuah, R., Cherney, D. Z. I., & Lam, T. K. T. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00951-7 · Cited by 91
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells
Vergari, E., Denwood, G., Salehi, A., Zhang, Q., Adam, J., Alrifaiy, A., Wernstedt Asterholm, I., Benrick, A., Chibalina, M. V., Eliasson, L., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0158-0 · Cited by 43
Metadata
- Authors
- Ghezzi, C., Loo, D. D. F., & Wright, E. M.
- Venue
- Diabetologia
- Published
- 2018-08-22
- Volume
- 61
- Issue
- 10
- Pages
- 2087-2097
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2883722299
- Cited by
- 348
- References
- 48
- FWCI
- 20.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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