Scaling of Subcellular Structures
Open accessAbstract
As cells grow, the size and number of their internal organelles increase in order to keep up with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer and an important aspect of diagnosis in cytopathology. Most organelles vary in either size or number, or both, as a function of cell size, but the mechanisms that create this variation remain unclear. In some cases, organelle size appears to scale with cell size through processes of relative growth, but in others the size may be set by either active measurement systems or genetic programs that instruct organelle biosynthetic activities to create organelles of a size appropriate to a given cell type.
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The volume of several cellular structures in the cell correlates with overall cell volume, including the nucleus and mitochondria.
“It has previously been shown that the volume of several cellular structures in the cell correlates with the overall cell volume, including the nucleus and mitochondria24.”
From Integrated intracellular organization and its variations in human iPS cells (2023) · cites this paper as [24]
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Integrated intracellular organization and its variations in human iPS cells
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“Cells were cultured in a Cytomat 24 (Thermo Fisher Scientific) at 37 °C and 5% CO 2 in mTeSR1 medium with and without phenol red (STEMCELL Technologies), supplemented with 1% penicillin–streptomycin (Thermo Fisher Scientific).”
- Authors
- Marshall, W. F.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Marshall, Wallace F.
- ORCID
- Marshall, Wallace F.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2020-10-06
- Volume
- 36
- Issue
- 1
- Pages
- 219-236
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC8562892
- OpenAlex
- W3039274856
- Cited by
- 54
- References
- 87
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R35GM130327)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cell size, relative growth, cancer, cytopathology
- MeSH terms
- Animals, Humans, Models, Biological, Subcellular Fractions, Organelles
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