Heterochromatin: Guardian of the Genome

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Transposable elements and the epigenetic regulation of the genome

Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Guelen, L., Pagie, L., Brasset, É., Meuleman, W. R. A., Faza, M. B., Talhout, W., Eussen, B. H. J., de Klein, A., Wessels, L. F. A., de Laat, W. L., et al. (2008) · Nature · doi:10.1038/nature06947 · Cited by 2,042

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009

Phase separation drives heterochromatin domain formation

Strom, A. R., Emelyanov, A. V., Mir, M., Fyodorov, D. V., Darzacq, X., & Karpen, G. H. (2017) · Nature · doi:10.1038/nature22989 · Cited by 1,789

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Larson, A. G., Elnatan, D., Keenen, M. M., Trnka, M. J., Johnston, J. B., Burlingame, A. L., Agard, D. A., Redding, S., & Narlikar, G. J. (2017) · Nature · doi:10.1038/nature22822 · Cited by 1,717

The impact of retrotransposons on human genome evolution

Cordaux, R., & Batzer, M. A. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2640 · Cited by 1,692

Karyotype Evolution in 10 Pinniped Species: Variability of Heterochromatin versus High Conservatism of Euchromatin as Revealed by Comparative Molecular Cytogenetics

Beklemisheva, V. R., Perelman, P. L., Lemskaya, N. A., Proskuryakova, A. A., Serdyukova, N. A., Николаевич, Б. В., Gorshunov, M. B., Ryder, O. A., Thompson, M. A., Lento, G. M., et al. (2020) · Genes · doi:10.3390/genes11121485 · Cited by 14

Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development

Chu, D. B., Nguyen, A., Smith, S. S., Vavrušová, Z., & Schneider, R. A. (2020) · Biology Open · doi:10.1242/bio.055343 · Cited by 13

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cellsPreprint

Novo, C. L., Wong, E. V., Hockings, C., Poudel, C., Sheekey, E., Walker, S. A., Schierle, G. S. K., Narlikar, G. J., & Rugg‐Gunn, P. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.08.139642 · Cited by 14

Expansion in situ genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repressionPreprint

Labade, A. S., Chiang, Z., Comenho, C., Reginato, P., Payne, A. C., Earl, A., Shrestha, R., Duarte, F. M., Habibi, E., Zhang, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.24.614614 · Cited by 14

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Gaurav, N., O’Hara, R. A., Hyder, U., Qin, W., Her, C., Romero, H., Kumar, A., Marcaida, M. J., Singh, R. K., Hovius, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60279-2 · Cited by 14

Genome‐wide DNA methylation dynamics following recent polyploidy in the allotetraploid Tragopogon miscellus (Asteraceae)

Shan, S., Gitzendanner, M. A., Boatwright, J. L., Spoelhof, J. P., Ethridge, C. L., Ji, L., Liu, X., Soltis, P. S., Schmitz, R. J., & Soltis, D. E. (2024) · New Phytologist · doi:10.1111/nph.19655 · Cited by 14

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance

Li, Z., & Qian, D. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01348-6 · Cited by 14

Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation

Kim, H. S., Roche, B., Bhattacharjee, S., Touat‐Todeschini, L., Chang, A.-Y., Hammell, C. M., Verdel, A., & Martienssen, R. A. (2024) · Nature Communications · doi:10.1038/s41467-024-53417-9 · Cited by 13

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

Dong, Z., Sepúlveda, H., Arteaga-Vazquez, L. J., Blouin, C., Fernandez, J. A., Binder, M., Chou, W., Tien, H., Patnaik, M. M., Faulkner, G. J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413302121 · Cited by 13

The shifting paradigm of chromatin structure: from the 30-nm chromatin fiber to liquid-like organization

Maeshima, K. (2025) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.101.020 · Cited by 18

The nucleosomes that mark centromere location on chromosomes old and new

Gambogi, C. W., & Black, B. E. (2019) · Essays in Biochemistry · doi:10.1042/ebc20180060 · Cited by 13

Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis

Walther, M., Schrahn, S., Krauß, V., Lein, S., Kessler, J., Jenuwein, T., & Reuter, G. (2020) · Chromosoma · doi:10.1007/s00412-020-00732-x · Cited by 13

Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription

Chang, R. C.-A., Thomas, K. N., Mehta, N. A., Veazey, K. J., Parnell, S. E., & Golding, M. C. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00403-w · Cited by 13

miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway

Guan, C.-Y., Cao, J., Zhang, L., Wang, X., Ma, X., & Xia, H.-F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.917386 · Cited by 13

Epigenetics across the evolutionary tree: New paradigms from non‐model animals

Sadler, K. C. (2022) · BioEssays · doi:10.1002/bies.202200036 · Cited by 14

Driving Chromatin Organisation through N6-methyladenosine Modification of RNA: What Do We Know and What Lies Ahead?

Selmi, T., & Lanzuolo, C. (2022) · Genes · doi:10.3390/genes13020340 · Cited by 14

Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis

Yadav, R. P., Leskinen, S., Ma, L., Mäkelä, J., & Kotaja, N. (2022) · Reproduction · doi:10.1530/rep-22-0240 · Cited by 12

Multi-Scale Imaging of the Dynamic Organization of Chromatin

Fernández, F. G., Huet, S., & Miné-Hattab, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115975 · Cited by 13

Epigenetic regulation of NKG2D ligand and the rise of NK cell-based immunotherapy for cancer treatment

Kumar, R., & Gupta, R. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1456631 · Cited by 12

Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence

Xie, J., Lu, Z., Bai, S., Cui, X., Lian, H.-Y., Xie, C.-Y., Wang, N., Wang, L., & Han, Z. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00212-3 · Cited by 14

Prenatal Perfluoroalkyl Substance Exposure in Association with Global Histone Post-Translational Methylation in 2-Year-Old Children

Tsai, W.-J., Hsieh, W., Chen, P., & Liu, C.-Y. (2024) · Toxics · doi:10.3390/toxics12120876 · Cited by 14

H3K36 methylation stamps transcription resistive to preserve development in plants

Yao, Y., Zhou, J., Wang, J., Lei, X., Jiang, A., & Sun, Q. (2025) · Nature Plants · doi:10.1038/s41477-025-01962-6 · Cited by 12

Streptonigrin at low concentration promotes heterochromatin formation

Loyola, A. C., Dao, K., Shang, R., Zhang, L., Dutta, P., Fowler, C. C., Li, J., & Li, W. X. (2020) · Scientific Reports · doi:10.1038/s41598-020-60469-6 · Cited by 12

Recent insights into mechanisms preventing ectopic centromere formation

Dong, Q., Yang, J., Gao, J., & Li, F. (2021) · Open Biology · doi:10.1098/rsob.210189 · Cited by 11

Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity

Lee, S., Abini-Agbomson, S., Perry, D. S., Goodman, A., Rao, B., Huang, M. Y., Diedrich, J. K., Moresco, J. J., Yates, J. R., Armache, K., et al. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01000-z · Cited by 12

Correlative Light and Electron Microscopy (CLEM) Analysis of Nuclear Reorganization Induced by Clustered DNA Damage Upon Charged Particle Irradiation

Tonnemacher, S., Eltsov, M., & Jakob, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061911 · Cited by 12

Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation

Ban, H., Sun, W., Chen, Y.-H., Chen, Y., & Li, F. (2021) · Genetics · doi:10.1093/genetics/iyab032 · Cited by 12

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

Kendek, A., Wensveen, M. R., & Janssen, A. (2021) · Genes · doi:10.3390/genes12091415 · Cited by 14

Emerging roles of histone methylation in phytopathogenic fungi

Zhang, Q., & Zeng, T. (2025) · aBIOTECH · doi:10.1007/s42994-025-00223-6 · Cited by 11

Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy

Melters, D. P., Neuman, K. C., Bentahar, R. S., Rakshit, T., & Dalal, Y. (2023) · eLife · doi:10.7554/elife.86709 · Cited by 11

Amplification of different satellite-DNAs in prostate cancer

Ariffen, N. A., Ornellas, A. A., Alves, G., Shana'ah, A. M., Sharma, S., Kankel, S., Jamali, E., Theis, B., & Liehr, T. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155269 · Cited by 11

Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation

Shao, Z., Lu, J., Khudaverdyan, N., & Song, J. (2024) · Nature Communications · doi:10.1038/s41467-024-51246-4 · Cited by 12

RNA impacts formation of biomolecular condensates in the nucleus

Matsui, S., & Nozawa, R. (2021) · Biomedical Research · doi:10.2220/biomedres.42.153 · Cited by 11

Meta‐analysis of the association between chromosomal polymorphisms and outcomes of embryo transfer following in vitro fertilization and/or intracytoplasmic sperm injection

Ou, Z., Yin, M.-N., Chen, Z., & Sun, L. (2018) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12702 · Cited by 11

Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate in C. elegans

DasGupta, A., Lee, T. L., Li, C., & Saltzman, A. L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590195 · Cited by 11

Long RNA-Mediated Chromatin Regulation in Fission Yeast and Mammals

Faber, M. W., & Vo, T. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020968 · Cited by 11

Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer’s Patients: A Biphasic Regulation of Neurogenesis

Gil, L., Chi-Ahumada, É., Niño, S. A., Capdeville, G., Méndez-Torres, A. M., Guerrero, C., Poves, A. B. R., Olazabal, I. M., & Jiménez-Capdeville, M. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112873 · Cited by 10

A genomic and epigenomic view of human centromeres

Jaggi, K. E., Hoyt, S. J., O'Neill, R. J. W., & Sullivan, B. A. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-025-00923-1 · Cited by 10

A predictive chromatin architecture nexus regulates transcription and DNA damage repair

Bhat, A., Bhan, S., Kabiraj, A., PANDITA, R. K., Ramos, K. S., Nandi, S., Sopori, S., Sarkar, P. S., Dhar, A., Pandita, S., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108300 · Cited by 12

Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome

Wang, S. E., Cheng, Y., Lim, J., Jang, M., Forrest, E., Kim, Y., Donahue, M., Jo, S., Qiao, S.-N., Lee, D. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61156-8 · Cited by 10

Shining Light on the Dark Side of the Genome

Wallrath, L. L., Rodríguez, F., & Geyer, P. (2022) · Cells · doi:10.3390/cells11030330 · Cited by 10

Can aggressive cancers be identified by the “aggressiveness” of their chromatin?

Gurova, K. V. (2022) · BioEssays · doi:10.1002/bies.202100212 · Cited by 9

Chromosomal Heteromorphisms and Cancer Susceptibility Revisited

Liehr, T. (2022) · Cells · doi:10.3390/cells11203239 · Cited by 10

The impact of chromatin on double-strand break repair: Imaging tools and discoveries

van Bueren, M. A. E., & Janssen, A. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103592 · Cited by 11

The Paramount Role of Drosophila melanogaster in the Study of Epigenetics: From Simple Phenotypes to Molecular Dissection and Higher-Order Genome Organization

Gibert, J., & Peronnet, F. (2021) · Insects · doi:10.3390/insects12100884 · Cited by 11

Shaping of genome by long noncoding RNAs

Ichikawa, Y., & Saitoh, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823579-9.00018-7 · Cited by 9

Liquid-liquid phase separation: a new perspective on respiratory diseases

Wang, L., Wang, Y., Ke, Z., Wang, Z., Guo, Y., Zhang, Y., Zhang, X., Guo, Z., & Wan, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1444253 · Cited by 9

The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

Sinha, J., Nickels, J. F., Thurm, A. R., Ludwig, C., Archibald, B. N., Hinks, M. M., Wan, J., Fang, D., & Bintu, L. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.09.015 · Cited by 14

The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer

Akano, I., Hebert, J. M., Tiedemann, R. L., Gao, Q., Xiao, Y. F., Prescott, N. A., Liu, Y., Tan, K. S., Bastle, R. M., Ramakrishnan, A., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.020 · Cited by 10

WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster

Cappucci, U., Casale, A. M., Proietti, M., Marinelli, F., Giuliani, L., & Piacentini, L. (2022) · Cells · doi:10.3390/cells11244036 · Cited by 11

Structural variations of subterminal satellite blocks and their source mechanisms as inferred from the meiotic configurations of chimpanzee chromosome termini

Hirai, H., Hirai, Y., Udono, T., Matsubayashi, K., Tosi, A. J., & Koga, A. (2019) · Chromosome Research · doi:10.1007/s10577-019-09615-z · Cited by 9

Regulation of epigenetic processes by non-coding RNAs

Heyt, K. M., & Thakur, J. (2021) · The Nucleus · doi:10.1007/s13237-021-00372-1 · Cited by 9

TGF-β controls stromal telomere length through epigenetic modifications

Mishra, R., Haldar, S., Biondi, S., Bhari, V. K., Singh, G., & Bhowmick, N. A. (2022) · 3 Biotech · doi:10.1007/s13205-022-03346-5 · Cited by 9

The chromatin – triple helix connection

Maldonado, R., & Längst, G. (2023) · Biological Chemistry · doi:10.1515/hsz-2023-0189 · Cited by 9

YTHDF2 promotes DNA damage repair by positively regulating the histone methyltransferase SETDB1 in spermatogonia

Guo, M. Z., Li, X., Li, T., Liu, R., Pang, W., Luo, J., Zeng, W., & Zheng, Y. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad136 · Cited by 9

The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

Bauwens, S., Lototska, L., Koundrioukoff, S., Debatisse, M., Ye, J., Gilson, É., & Méndez-Bermúdez, A. (2021) · Life · doi:10.3390/life11040267 · Cited by 9

Suv420 enrichment at the centromere limits Aurora B localization and function

Herlihy, C. P., Hahn, S., Hermance, N. M., Crowley, E. A., & Manning, A. L. (2021) · Journal of Cell Science · doi:10.1242/jcs.249763 · Cited by 9

HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalizationPreprint

Brennan, L. D., Kim, H.-K., Colmenares, S., Ego, T., Ryu, J.-K., & Karpen, G. H. (2025) · bioRxiv · doi:10.1101/2024.10.18.618981 · Cited by 7

Reduction of histone proteins dosages increases CFW sensitivity and attenuates virulence of Candida albicans

Dong, Y., Du, J., Deng, Y., Cheng, M., Shi, Z., Zhu, H., Sun, H., Yu, Q., & Li, M. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127552 · Cited by 8

Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing

Carlier, F., Ramirez, S. C., Kilani, J., Chehboub, S., Loïodice, I., Taddei, A., & Gladyshev, E. A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402944121 · Cited by 8

Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair

Colicino-Murbach, E., Hathaway, C., & Dungrawala, H. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae721 · Cited by 8

Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

Fujiwara, K., Inoue, T., Kimoto, A., Zixian, J., Tokuhiro, K., Yasukochi, Y., Akama, T. O., Cai, C., Shiojima, I., Kimurâ, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115048 · Cited by 8

Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres

Fukagawa, T., & Kakutani, T. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102021 · Cited by 8

G × E interactions as a basis for toxicological uncertainty

Suciu, I., Pamies, D., Peruzzo, R., Wirtz, P. H., Smirnova, L., Pallocca, G., Hauck, C. R., Cronin, M., Hengstler, J. G., Brunner, T., et al. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03500-9 · Cited by 15

Depletion of HP1α alters the mechanical properties of MCF7 nuclei

Pradhan, S., Solomon, R., Gangotra, A., Yakubov, G. E., Willmott, G. R., Whitby, C. P., Hale, T. K., & Williams, M. A. K. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.05.017 · Cited by 8

Heterochromatic hues of transcription—the diverse roles of noncoding transcripts from constitutive heterochromatin

Saha, P., & Mishra, R. K. (2019) · FEBS Journal · doi:10.1111/febs.15104 · Cited by 8

Evolutionary Dynamics of the Pericentromeric Heterochromatin in Drosophila virilis and Related Species

Rezvykh, A. P., Funikov, S. Y., Protsenko, L. A., Kulikova, D. A., Zelentsova, E. S., Chuvakova, L. N., Blumenstiel, J. P., & Evgen’ev, M. B. (2021) · Genes · doi:10.3390/genes12020175 · Cited by 8

Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity

Sebastian, R., Aladjem, M. I., & Oberdoerffer, P. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.746380 · Cited by 8

Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation

Padilla‐Benavides, T., Olea‐Flores, M., Sharma, T., Syed, S. A., Witwicka, H., Zuñiga‐Eulogio, M. D., Zhang, K., Navarro‐Tito, N., & Imbalzano, A. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411256 · Cited by 7

SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts

Huang, Z., Cui, W., Ratnayake, I. S., Gallik, K. L., Cohen, L., Tawil, R., & Pfeifer, G. P. (2025) · Nature Communications · doi:10.1038/s41467-025-62211-0 · Cited by 7

A Tale of Two States: Pluripotency Regulation of Telomeres

Novo, C. L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703466 · Cited by 7

Pericentric major satellite transcription is essential for meiotic chromosome stability and spindle pole organization

Baumann, C., Zhang, X., Viveiros, M. M., & Fuente, R. D. L. (2023) · Open Biology · doi:10.1098/rsob.230133 · Cited by 7

The 20S proteasome activator PA28γ controls the compaction of chromatin

Fesquet, D., Llères, D., Grimaud, C., Viganó, C., Méchali, F., Boulon, S., Coux, O., Bonne-Andréa, C., & Baldin, V. (2021) · Journal of Cell Science · doi:10.1242/jcs.257717 · Cited by 7

Imaging the Response to DNA Damage in Heterochromatin Domains

Chansard, A., Pobega, E., Caron, P., & Polo, S. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.920267 · Cited by 7

Ultrastructural Analysis of Cancer Cells Treated with the Radiopharmaceutical Radium Dichloride ([223Ra]RaCl2): Understanding the Effect on Cell Structure

Filho, J. F. S. D., de Barros, A. O. D. S., Pijeira, M. S. O., Ricci‐Júnior, E., Midlej, V. D. V. P., Baroni, M. P. M. A., dos Santos, C. C., Alencar, L. M. R., & Santos‐Oliveira, R. (2023) · Cells · doi:10.3390/cells12030451 · Cited by 7

Toward decoding the mechanisms that shape sub-megabase-scale genome organization

Paggi, J. M., & Zhang, B. (2025) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2025.103062 · Cited by 7

Forced expression of MSR repeat transcripts above a threshold limit breaks heterochromatin organisation

Ching, R. W., Świst-Rosowska, K. M., Erikson, G. A., Koschorz, B., Engist, B., & Jenuwein, T. (2025) · Nature Communications · doi:10.1038/s41467-025-61586-4 · Cited by 6

Strigolactone signaling repressor SMXL7 modulates genome architecture via JMJ30 ‐mediated H3K27me3 demethylation in Arabidopsis

Li, J., Xu, G., Qu, G., Ma, H., He, Z., Sun, M., Gao, L., Yu, H., Wang, Y., Zhang, Y., et al. (2025) · New Phytologist · doi:10.1111/nph.70580 · Cited by 6

Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein

Rajshekar, S., Adame-Arana, O., Bajpai, G., Colmenares, S. U., Papoi, H., Brennan, L. D., Tsukamoto, S., Safran, S. A., & Karpen, G. H. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01806-7 · Cited by 8

Radiation and Diabetic Retinopathy: A Dark Synergy

Gardiner, T. A., ARCHER, D. B., Silvestri, G., & Amoaku, W. M. K. (2023) · International Journal of Translational Medicine · doi:10.3390/ijtm3010011 · Cited by 6

The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B

Sun, W., Dong, Q., Li, X., Gao, J., Ye, X., Hu, C., Li, F., & Chen, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-48418-7 · Cited by 6

Cytogenetic events in the endosperm of amphiploid Avena magna × A. longiglumis

Tomaszewska, P., & Kosina, R. (2021) · Journal of Plant Research · doi:10.1007/s10265-021-01314-3 · Cited by 6

Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin

Zhang, J., Bellani, M. A., Huang, J., James, R. C., Pokharel, D., Gichimu, J., Gali, H., Stewart, G. S., & Seidman, M. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.729265 · Cited by 6

53BP1: guarding the genome with a novel liquid weapon

Tangudu, N. K., & Aird, K. M. (2022) · Communications Biology · doi:10.1038/s42003-022-03401-0 · Cited by 6

Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin

Misra, S., Chowdhury, S. G., Ghosh, G., Mukherjee, A., & Karmakar, P. (2022) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2022.111800 · Cited by 6

Integrating Genomic and Chromosomal Data: A Cytogenetic Study of Transancistrus santarosensis (Loricariidae: Hypostominae) with Characterization of a ZZ/ZW Sex Chromosome System

Nirchio, M., Cioffi, M. D. B., Sassi, F. D. M. C., Deon, G. A., Oliveira, C., Kuranaka, M., Valdiviezo‐Rivera, J., Gonzalez, V. H., & Rossi, A. R. (2023) · Genes · doi:10.3390/genes14091662 · Cited by 6

High levels of intra-strain structural variation in Drosophila simulans X pericentric heterochromatin

Courret, C., & Larracuente, A. M. (2023) · Genetics · doi:10.1093/genetics/iyad176 · Cited by 6

Role of Trifluoroacetic Acid Anions in pHP1α Liquid–Liquid Phase Separations

Chin, S. Y., Chen, Y., Zhao, L., Chng, C., Kuang, J., Zhai, Z., Lu, Y., Huang, C., Shi, C., Shi, X., et al. (2025) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5c03218 · Cited by 5

BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells

Gallardo, A., Belmonte‐Reche, E., Marti-Marimon, M., Domingo-Reinés, J., Peris, G., López-Onieva, L., Fernández-Rengel, I., Xie, J., Tristán-Ramos, P., Bellora, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63778-4 · Cited by 5

HISTONE DEACETYLASE-1 is required for epigenome stability in Neurospora crassa

Ebot-Ojong, F., Ferraro, A. R., Yap, R. E., Kaddar, F., Hull-Crew, C., Scadden, A. W., Deaven, A. M., Klocko, A. D., & Lewis, Z. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2503876122 · Cited by 6

Chromatin Regulation of HSV Gene Transcription

Zheng, Y., Zhang, J., & Pan, D. (2025) · Viruses · doi:10.3390/v17111409 · Cited by 5

Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes: a retrospective cohort study

Lu, Y., Tian, T., Chen, L., Yan, L., Chang, L., & Qiao, J. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06532-w · Cited by 5

Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly

Colmenares, S. U., Tsukamoto, S., Hickmann, C., Brennan, L. D., Khavani, M., Mofrad, M. R. K., & Karpen, G. H. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf976 · Cited by 8

Genome size versus geographic range size in birds

Grzywacz, B., & Skórka, P. (2021) · PeerJ · doi:10.7717/peerj.10868 · Cited by 5

Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination

Mladenov, E., Paul‐Konietzko, K., Mladenova, V., Stuschke, M., & Iliakis, G. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169180 · Cited by 5

CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States

Jeffery, D., Lochhead, M., & Almouzni, G. (2022) · Results and problems in cell differentiation · doi:10.1007/978-3-031-06573-6_7 · Cited by 5

Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation

Khella, M. S., Bröhm, A., Weirich, S., & Jeltsch, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228832 · Cited by 5

An RNA-interference screen in Drosophila to identify ZAD-containing C2H2 zinc finger genes that function in female germ cells

Shapiro-Kulnane, L., Bautista, O., & Salz, H. K. (2020) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaa016 · Cited by 5

Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndromePreprint

Zhou, L., Ge, C., Malachowski, T., Kim, J. H., Chandradoss, K. R., Chuanbin, S., Wu, H., Rojas, L. A., Wallace, O. B., Titus, K. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.23.441217 · Cited by 5

Transposons Repressed by H3K27me3 Were Co-Opted as Cis-Regulatory Elements of H3K27me3 Controlled Protein Coding Genes During Evolution of PlantsPreprint

Hisanaga, T., Romani, F., Wu, S., Kowar, T., Lintermann, R., Jamge, B., Montgomery, S. A., Axelsson, E., Akimcheva, S., Dierschke, T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513474 · Cited by 5

Heterochromatin: A Critical Part of the Genome

Wallrath, L. L., Vitalini, M. W., & Elgin, S. C. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_13 · Cited by 6

Epigenetic regulation of heterochromatic DNA stability

Peng, J. C., & Karpen, G. H. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.021 · Cited by 214

L’hétérochromatine constitutive dans tous ses états

Terranova, R. (2008) · médecine/sciences · doi:10.1051/medsci/20082489720 · Cited by 6

Heterochromatin and Euchromatin-Organization, Boundaries, and Gene Regulation

Strålfors, A., & Ekwall, K. (2011) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200400018.pub2 · Cited by 8

Drosophila heterochromatin: structure and function

Mteirek, R., Gueguen, N., Jensen, S., Brasset, É., & Vaury, C. (2014) · Current Opinion in Insect Science · doi:10.1016/j.cois.2014.04.003 · Cited by 7