The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Developmental Control of Transposable Elements and the Evolution of Higher Species
Open accessAbstract
Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight epigenetic control during the earliest phases of embryonic development via histone and DNA methylation. Key to this process is recognition by sequence-specific RNA- and protein-based repressors. Collectively, these mediators are responsible for silencing a very broad range of TEs in an evolutionarily dynamic fashion. As a consequence, mobile elements and their controllers exert a marked influence on transcriptional networks in embryonic stem cells and a variety of adult tissues. The emerging picture is not that of a simple arms race but rather of a massive and sophisticated enterprise of TE domestication for the evolutionary benefit of the host.
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Cites
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Cited by
Regulatory activities of transposable elements: from conflicts to benefits
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Restricting retrotransposons: a review
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Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
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Self-citation
Metadata
- Authors
- Friedli, M., & Trono, D.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2015-11-13
- Volume
- 31
- Issue
- 1
- Pages
- 429-451
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2153220649
- Cited by
- 277
- References
- 43
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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