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Cited by 63Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Architecture and Dynamics of the Neuronal Secretory Network

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Kennedy, Matthew J., Hanus, Cyril·2019·Annual Review of Cell and Developmental Biology
DOI 10.1146/annurev-cellbio-100818-125418PMC PMC6935261
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Abstract

Regulated synthesis and movement of proteins between cellular organelles are central to diverse forms of biological adaptation and plasticity. In neurons, the repertoire of channel, receptor, and adhesion proteins displayed on the cell surface directly impacts cellular development, morphology, excitability, and synapse function. The immensity of the neuronal surface membrane and its division into distinct functional domains present a challenging landscape over which proteins must navigate to reach their appropriate functional domains. This problem becomes more complex considering that neuronal protein synthesis is continuously refined in space and time by neural activity. Here we review our current understanding of how integral membrane and secreted proteins important for neuronal function travel from their sites of synthesis to their functional destinations. We discuss how unique adaptations to the function and distribution of neuronal secretory organelles may facilitate local protein trafficking at remote sites in neuronal dendrites to support diverse forms of synaptic plasticity.

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Sorted by citations

Authors
Kennedy, M. J., & Hanus, C.
Affiliations
  • University of Colorado Anschutz (US)
  • Inserm (FR)
ORCID
Venue
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Published
2019-10-06
Volume
35
Issue
1
Pages
543-566
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
DOI
10.1146/annurev-cellbio-100818-125418
PMC
PMC6935261
OpenAlex
W2958571635
Cited by
63
References
3
Citations by year
2026: 8 · 2025: 11 · 2024: 2 · 2023: 8 · 2022: 9 · 2021: 18 · 2020: 7
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-16-CE16-0009)
  • Institut National de la Santé et de la Recherche Médicale
  • Université de Paris
  • National Institute on Aging (R21AG058005)
  • National Institute of Neurological Disorders and Stroke (UF1NS107710, R01NS107554, F32NS010755, R01NS082271)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
protein trafficking, secretory organelles, synaptic plasticity, membrane protein localization, dendrites
MeSH terms
Animals, Cell Compartmentation, Cell Membrane, Dendrites, Endoplasmic Reticulum, Golgi Apparatus, Membrane Proteins, Neuronal Plasticity, Neurons, Endosomes, Synapses, Protein Transport

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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