Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons
Open accessAbstract
The use-dependent modification of synapses is strongly influenced by dopamine, a transmitter that participates in both the physiology and pathophysiology of animal behavior. In the hippocampus, dopaminergic signaling is thought to play a key role in protein synthesis-dependent forms of synaptic plasticity. The molecular mechanisms by which dopamine influences synaptic function, however, are not well understood. Using a GFP-based reporter, as well as a small-molecule reporter of endogenous protein synthesis, we show that dopamine D1/D5 receptor activation stimulates local protein synthesis in the dendrites of hippocampal neurons. We also identify the GluR1 subunit of AMPA receptors as one protein upregulated by dopamine receptor activation, with increased incorporation of surface GluR1 at synaptic sites. The insertion of new GluRs is accompanied by an increase in the frequency of miniature synaptic events. Together, these data suggest a local protein synthesis-dependent activation of previously silent synapses as a result of dopamine receptor stimulation.
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Dopamine enhances protein synthesis within dendrites of hippocampal neurons.
“Dopamine enhances protein synthesis within dendrites of hippocampal neurons [85].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [85]
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- Authors
- Smith, W. B., Starck, S. R., Roberts, R. W., & Schuman, E. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- California Institute of Technology (US)
- Corresponding author
- Schuman, Erin M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 45
- Issue
- 5
- Pages
- 765-779
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2091597912
- Cited by
- 252
- References
- 63
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 19 · 2012: 17
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dopamine, local protein synthesis, GluR1, AMPA receptors, synaptic plasticity, hippocampal neurons, dendritic protein synthesis, cell surface receptor expression, silent synapses, synaptic transmission
- MeSH terms
- Animals, Cells, Cultured, Gene Expression Regulation, Hippocampus, Synaptic Transmission, Neurons, Proteins, Receptors, Dopamine, Synapses, Rats, Sprague-Dawley, Receptors, AMPA, Dopamine Agonists, Rats
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