The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles
Open accessAbstract
The rhomboid proteases were first discovered as regulators of Drosophila EGF receptor signaling; soon after, it was recognized that they represented the founder members of a widespread family of intramembrane serine proteases conserved in all kingdoms. More recently still, the family was promoted to a superfamily, encompassing a wide variety of distantly related proteins. One of the surprises has been that many members of the rhomboid-like superfamily are not active proteases. Given the size of this clan, and its relatively recent discovery, there is still much to learn. Nevertheless, we already understand much about how rhomboid proteases perform their surprising function of cleaving transmembrane domains. We also already know that members of the rhomboid-like superfamily participate in biological functions as diverse as growth factor signaling, mitochondrial dynamics, inflammation, parasite invasion, and the machinery of protein quality control. Their potential medical significance is now becoming apparent in several areas.
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- Authors
- Freeman, M.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Freeman, Matthew
- ORCID
- Freeman, Matthew
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2014-10-11
- Volume
- 30
- Issue
- 1
- Pages
- 235-254
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2100884747
- Cited by
- 145
- References
- 2
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 8 · 2019: 18 · 2018: 21 · 2017: 7 · 2016: 20 · 2015: 4 · 2014: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (101035/Z/13/Z, 101035)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- rhomboid protease, intramembrane serine proteases, EGF receptor signaling, growth factor signaling, mitochondrial dynamics, inflammation, parasite invasion, protein quality control
- MeSH terms
- Animals, Carrier Proteins, Multigene Family, Humans, Inflammation, Mammals, Membrane Proteins, Mitochondria, Terminology as Topic, Parasitic Diseases, Plant Proteins, Catalytic Domain, Mitochondrial Proteins, Drosophila Proteins, Serine Proteases, Proteolysis
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