Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Rhomboid Protease PARL
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Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 (PARL ortholog) maintains the function and lifecycle of mitochondria. We examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin resistance. PARL mRNA and mitochondrial mass were both reduced in elderly subjects and in subjects with T2DM. Muscle knockdown of PARL in mice resulted in malformed mitochondrial cristae, lower mitochondrial content, decreased PGC1alpha protein levels, and impaired insulin signaling. Suppression of PARL protein in healthy myotubes lowered mitochondrial mass and insulin-stimulated glycogen synthesis and increased reactive oxygen species production. We propose that lower PARL expression may contribute to the mitochondrial abnormalities seen in aging and T2DM.
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PARL levels are reduced in skeletal muscle during aging and type 2 diabetes mellitus.
“PARL levels are reduced in skeletal muscle during aging and type 2 diabetes mellitus [168].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [168]
In mice, muscle knockdown of PARL results in alteration in mitochondrial cristae morphology, mitochondrial dysfunction, oxidative stress, and altered insulin signaling, probably explained by reduction in PARL-mediated OPA1 processing.
“In mice, muscle knockdown of PARL results in an alteration in mitochondrial cristae morphology, mitochondrial dysfunction, oxidative stress, and altered insulin signaling, which probably can be explained by the reduction in PARL-mediated OPA1 processing [168].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [168]
Suppression of PARL protein in cultured healthy human myotubes lowers mitochondrial mass and insulin-stimulated glycogen synthesis and increases reactive oxygen species production.
“Suppression of PARL protein in cultured healthy human myotubes lowered mitochondrial mass and insulin-stimulated glycogen synthesis and increased reactive oxygen species production (60).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [60]
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Rhomboid proteases: key players at the cell surface within haloarchaea
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- Authors
- Civitarese, A. E., MacLean, P. S., Carling, S., Kerr-Bayles, L., McMillan, R. P., Pierce, A., Becker, T. C., Moro, C., Finlayson, J., Lefort, N., Newgard, C. B., Mandarino, L., Cefalu, W., Walder, K., Collier, G. R., Hulver, M. W., Smith, S. R., & Ravussin, E.
- Affiliations
- Pennington Biomedical Research Center (US)
- University of Colorado Denver (US)
- Deakin University (AU)
- Virginia Tech (US)
- Duke University (US)
- Arizona State University (US)
- Mayo Clinic in Arizona (US)
- Corresponding author
- Civitarese, Anthony E.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 412-426
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3835349
- OpenAlex
- W1970594198
- Cited by
- 95
- References
- 95
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 10
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute on Aging (U01AG020478, R01 AG20478)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-67403, R01DK047936, K01DK067403, R01DK078765, R01DK066483, P30DK048520, P30DK072476)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- PARL, rhomboid protease, mitochondrial proteolysis, skeletal muscle, insulin resistance, type 2 diabetes, aging, mitochondrial mass, mitochondrial cristae, PGC-1α, insulin signaling, reactive oxygen species, glycogen synthesis, mitochondrial dysfunction
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Cells, Cultured, Diabetes Mellitus, Type 2, Glycogen, Humans, Insulin, Middle Aged, Mitochondria, Transcription Factors, Signal Transduction, Trans-Activators, Reactive Oxygen Species, Mice, Knockout, Muscle, Skeletal, Mitochondrial Proteins, Metalloproteases, Mice
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