How do cells adapt? stories told in landscapes
Open accessAbstract
Cells adapt to changing environments. Perturb a cell and it returns to a point of homeostasis. Perturb a population and it evolves toward a fitness peak. We review quantitative models of the forces of adaptation and their visualizations on landscapes. While some adaptations result from single mutations or few-gene effects, others are more cooperative, more delocalized in the genome, and more universal and physical. For example, homeostasis and evolution depend on protein folding and aggregation, energy and protein production, protein diffusion, molecular motor speeds and efficiencies, and protein expression levels. Models provide a way to learn about the fitness of cells and cell populations by making and testing hypotheses.
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Homeostasis is a property of a normal cell to maintain constant intracellular concentrations over a cell cycle, responding to perturbations by adjusting biochemical pathways to bring concentrations back into an acceptable range.
“Homeostasis is a property of a normal cell to maintain constant intracellular concentrations over a cell cycle suggesting that upon experiencing a perturbation whether from the environment or an intracellular reaction, it responds by adjusting its biochemical pathways to bring the concentrations back into an acceptable range for stable functioning of its networks (Agozzino et al., 2020).”
From Fundamental behaviors emerge from simulations of a living minimal cell (2022) · cites this paper as Agozzino et al., 2020
In “Simple Homeostasis: The Basic Idea” (page unavailable), the paper defines homeostasis as a stable biomolecule concentration maintained by opposing synthesis and degradation flows; the Introduction says cells return to a stable state after perturbation. It does not establish that intracellular concentrations remain constant over an entire cell cycle or specifically describe this as a property of a “normal cell.” (LLM, conf=0.86)
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- Authors
- Agozzino, L., Balázsi, G., Wang, J., & Dill, K. A.
- Affiliations
- Stony Brook University (US)
- Venue
- Annual Review of Chemical and Biomolecular Engineering
- Publisher
- Annual Reviews
- Published
- 2020-06-08
- Volume
- 11
- Issue
- 1
- Pages
- 155-182
- ISSN
- 1947-5438 (ISSN-L)
- 1947-5446
- PMC
- PMC7291840
- OpenAlex
- W3033782339
- Cited by
- 37
- References
- 108
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Annual Review of Chemical and Biomolecular Engineering (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM124177, R01GM125813, R35GM122561)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- cellular adaptation, homeostasis, evolution, fitness landscape, quantitative model, protein folding, protein aggregation, energy production, protein diffusion, molecular motors, protein abundance, single mutation, cell populations
- MeSH terms
- Adaptation, Physiological, Animals, Energy Metabolism, Humans, Models, Biological, Mutation, Proteins, RNA, Messenger, Protein Folding, Evolution, Molecular
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