The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Design and Scaling Up of Microchemical Systems: A Review
Open accessAbstract
The past two decades have witnessed a rapid development of microreactors. A substantial number of reactions have been tested in microchemical systems, revealing the advantages of controlled residence time, enhanced transport efficiency, high product yield, and inherent safety. This review defines the microchemical system and describes its components and applications as well as the basic structures of micromixers. We focus on mixing, flow dynamics, and mass and heat transfer in microreactors along with three strategies for scaling up microreactors: parallel numbering-up, consecutive numbering-up, and scale-out. We also propose a possible methodology to design microchemical systems. Finally, we provide a summary and future prospects.
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Cites
Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device
Thorsen, T., Roberts, R. W., Arnold, F. H., & Quake, S. R. (2001) · Physical Review Letters · doi:10.1103/physrevlett.86.4163 · Cited by 2,051
Reactions in Droplets in Microfluidic Channels
Song, H., Chen, D. L., & Ismagilov, R. F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601554 · Cited by 1,847
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Micromixers—a review on passive and active mixing principles
Hessel, V., Löwe, H., & Schönfeld, F. (2005) · Chemical Engineering Science · doi:10.1016/j.ces.2004.11.033 · Cited by 1,479
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
Gutmann, B., Cantillo, D., & Kappe, C. O. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201409318 · Cited by 1,469
The past, present and potential for microfluidic reactor technology in chemical synthesis
Elvira, K. S., i Solvas, X. C., Wootton, R. C. R., & deMello, A. J. (2013) · Nature Chemistry · doi:10.1038/nchem.1753 · Cited by 1,203
Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis
Hartman, R. L., McMullen, J. P., & Jensen, K. F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201004637 · Cited by 999
Self-citationMultiphase microfluidics: from flow characteristics to chemical and materials synthesis
Günther, A., & Jensen, K. F. (2006) · Lab Chip · doi:10.1039/b609851g · Cited by 983
Self-citationOn-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Adamo, A., Beingessner, R. L., Behnam, M., Chen, J., Jamison, T. F., Jensen, K. F., Monbaliu, J.-C. M., Myerson, A. S., Revalor, E. M., Snead, D. R., et al. (2016) · Science · doi:10.1126/science.aaf1337 · Cited by 941
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Cited by
The Fundamentals Behind the Use of Flow Reactors in Electrochemistry
Noël, T., Cao, Y., & Laudadio, G. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00412 · Cited by 572
Dong, G., Chen, B., Liu, B., Hounjet, L. J., Cao, Y., Stoyanov, S. R., Yang, M., & Zhang, B. (2022) · Water Research · doi:10.1016/j.watres.2022.118047 · Cited by 303
The sustainability of emerging technologies for use in pharmaceutical manufacturing
Weaver, E., O’Hagan, C., & Lamprou, D. A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2093857 · Cited by 70
“As mentioned though, there are drawbacks to manufacturing formulations with MF, including the difficulty in scaling up processes to an industrial level [76].”
Background
Metadata
- Authors
- Zhang, J., Wang, K., Teixeira, A. R., Jensen, K. F., & Luo, G.
- Venue
- Annual Review of Chemical and Biomolecular Engineering
- Publisher
- Annual Reviews
- Published
- 2017-06-07
- Volume
- 8
- Issue
- 1
- Pages
- 285-305
- ISSN
- 1947-5438 (ISSN-L)
- 1947-5446
- OpenAlex
- W2559791338
- Cited by
- 293
- References
- 79
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, J., Wang, K., Teixeira, A. R., Jensen, K. F., & Luo, G. (2017). Design and Scaling Up of Microchemical Systems: A Review. Annual Review of Chemical and Biomolecular Engineering. https://doi.org/10.1146/annurev-chembioeng-060816-101443
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
