The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.
Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration
Open accessAbstract
Postpartum depression (PPD) adversely affects the health and well being of many new mothers, their infants, and their families. A comprehensive understanding of biopsychosocial precursors to PPD is needed to solidify the current evidence base for best practices in translation. We conducted a systematic review of research published from 2000 through 2013 on biological and psychosocial factors associated with PPD and postpartum depressive symptoms. Two hundred fourteen publications based on 199 investigations of 151,651 women in the first postpartum year met inclusion criteria. The biological and psychosocial literatures are largely distinct, and few studies provide integrative analyses. The strongest PPD risk predictors among biological processes are hypothalamic-pituitary-adrenal dysregulation, inflammatory processes, and genetic vulnerabilities. Among psychosocial factors, the strongest predictors are severe life events, some forms of chronic strain, relationship quality, and support from partner and mother. Fully integrated biopsychosocial investigations with large samples are needed to advance our knowledge of PPD etiology.
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“Psychosocial stressors such as lack of support, prior psychiatric history, and negative childbirth experiences further increase the risk of developing PPD.11”
From Influence of Neuraxial Anesthesia Technique During Vaginal and Cesarean Delivery and Association with Postpartum Depression: A Narrative Review of Literature (2026) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Importantly, confounding variables from unmeasured psychosocial variables, such as partner support, socioeconomic stress, prior trauma, and access to mental health care may influence reported associations.11”
From Influence of Neuraxial Anesthesia Technique During Vaginal and Cesarean Delivery and Association with Postpartum Depression: A Narrative Review of Literature (2026) · cites this paper as [11]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The development of PPD is multifactorial, influenced by biological, psychological, and social determinants.11,12”
In the citing paper
“Likewise, although animal studies have documented complex neurobiological modifications associated with the mammalian transition to parenthood (Lambert, 2012), biological factors have yet to be properly integrated within psychosocial studies of distress in the perinatal period (Yim, Tanner Stapleton, Guardino, Hahn-Holbrook, & Dunkel Schetter, 2015).”
From Couples becoming parents: Trajectories for psychological distress and buffering effects of social support (2020) · cites this paper as Yim, Tanner Stapleton, Guardino, Hahn-Holbrook, & Dunkel Schetter, 2015
In the citing paper
“our anxious-depressive symptoms latent factor encompassed scores on three standardized measures (i.e., CESD, STAI and GHQ) and was supplemented by prenatal assessments of both maternal and paternal cortisol (Yim et al., 2015).”
From Couples becoming parents: Trajectories for psychological distress and buffering effects of social support (2020) · cites this paper as Yim et al., 2015
In the citing paper
“most studies tend to investigate the contribution of only one or two risk factors altogether (e.g., Hetherington, McDonald, Williamson, Patten and Tough, 2018 [14]), so the communalities between biopsychosocial factors are not controlled and the unique contribution of each variable remains unclear [15].”
From Predicting Postpartum Depressive Symptoms from Pregnancy Biopsychosocial Factors: A Longitudinal Investigation Using Structural Equation Modeling (2020) · cites this paper as [15]
In the citing paper
“For example, biological factors, such as reproductive and stress hormones, psychological variables, such as beliefs and perceived anxiety control, social factors such as marital satisfaction and peer support, and contextual information (i.e., seasonal time frame or seasonal light exposure), have also been linked with depressive symptomatology in perinatal research [15,61], but were not included in”
From Predicting Postpartum Depressive Symptoms from Pregnancy Biopsychosocial Factors: A Longitudinal Investigation Using Structural Equation Modeling (2020) · cites this paper as [15]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
Eysenck, H. J. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90087-7 · Cited by 32,038
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183
Research works printed but not linked: 8
- Battin DA, 1985, Obstet. Gynecol., 65, 785
- Chatterji P, 2012, J. Ment. Health Policy Econ., 15, 61
- First MB, 2002, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P)
- Herrmann WM, 1978, Postgrad. Med. J., 54, 82
- Itil TM, 1974, Curr. Ther. Res. Clin. Exp., 16, 1147
- Lowry PJ, 1993, Ciba Found. Symp., 172, 108
- McCoy SJ, 2003, J. Reprod. Med., 48, 402
- Scrandis DA, 2008, Int. J. Child Health Hum. Dev., 1, 167
Cited by
Sorted by citations
Items 801–832 of 832
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Baldi, E., Gfüllner, J., Meneo, D., Cerolini, S., Hoedlmoser, K., & Baglioni, C. (2026) · Brain Sciences · doi:10.3390/brainsci16080821
Breedt-Kriek, M., Bosman, H., & Moeketsi, T. D. (2026) · BJPsych International · doi:10.1192/bji.2026.10126
Bilgi, A., Yıldırım, O., Cungu, R., SAĞLAM, R. N., Kılıç, Ş., Çelık, Ç., & Külhan, M. (2026) · Gynecologic and Obstetric Investigation · doi:10.1159/000552902
Machine Learning-Based Prediction of Antepartum Depression Symptoms: A Prospective Cohort Study
Xie, H., Cong, S., Ni, S., Han, J., Sun, X., Zhu, R., Zhang, T., Wang, M., Wu, Y., & Zhang, A. (2026) · International Journal of Women s Health · doi:10.2147/ijwh.s599295
Ruiz-Tagle, F., & Pretorius, I. (2026) · Journal of Child Psychotherapy · doi:10.1080/0075417x.2026.2708990
Guo, H., Wang, Q., & Guo, Y. (2026) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph23091134
Behavioural and Neurobiological Effects of Early Postnatal Stress in Mouse Dams and Their Pups
Mordvinova, V. (2026) · uO Research (University of Ottawa) · doi:10.20381/ruor-32210
Anhedonia in Postpartum Depression: The Role of Neuroinflammation and Dopamine Dysfunction
Motiejūnas, J., Ušinskienė, J., Characiejus, D., Tamosiunas, A. E., Tutkuvienė, J., Jatužis, D., Masiulis, N., Levin, O., Griškevičius, R., & Navickas, A. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100826
Lin, L., Tang, H., Kuang, H., Yang, Y., & Zhao, H. (2026) · International Journal of Women s Health · doi:10.2147/ijwh.s618420
Identifying risk factors associated with postpartum depression: a retrospective case-control study
Volz, R., Coenen, V. A., Baldermann, J. C., & Döbrössy, M. D. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-09932-2
Profiling zuranolone as a treatment option for postpartum depression
Gonzalez‐Torres, C., & Sharma, V. (2026) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2026.2733192
Stoliar, S. C. (2026) · Cross Connect (Southern Cross University) · doi:10.25918/thesis.603
Mordvinova, V., Trowsse, T., & Audet, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.22.753354
Echabe-Ecenarro, O. (2025) · DeustoTeka
Positive Mental Health in the Perinatal Period: Biopsychosocial Factors and Intervention Strategies
Muslu, Ö. N. (2026) · Journal of Midwifery and Health Sciences · doi:10.62425/esbder.1686834
Giac, R., Chaput‐Langlois, S., Booij, L., Séguin, K., Brun, A., Ryan, N. C., Vaillancourt, C., Lippé, S., & Herba, C. M. (2026) · Infant Mental Health Journal · doi:10.1002/imhj.70117
Perspective Chapter: Gut–Brain Axis and Psychobiotics – New Horizons in the Treatment of Depression
Işık, M. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015811
Reviani, N., Sumarwan, U., Herawati, T., & Yuliati, L. N. (2025) · International Journal of Environmental Sciences · doi:10.64252/53v5ac17
Intervenção psicológica em contexto de cuidados de saúde primários
Militão, M. (2026) · Repositório Institucional da Universidade Autónoma de Lisboa (Universidade Autónoma de Lisboa)
Well-Being Beyond the Binary in Perinatal Healthcare: An Application of Reproductive Justice
Wright, O. (2026) · Digital Commons - DU (University of Denver) · doi:10.56902/etdcrp.2026.199
Laijawala, R., Bind, R. H., Alford, S., Estevao, C., Hazelgrove, K. M., Priestley, K., Rebecchini, L., Kirkpatrick, M., Miller, C., Sethna, V., et al. (2026) · BMJ Mental Health · doi:10.1136/bmjment-2026-302774
The Relationship Between Post-Earthquake Trauma Levels and Postpartum Depression Levels
Atabey, K., BENLİ, T. E., Sarıtaş, G., Doğan, M., Mohammadi, S., & Derya, Y. A. (2026) · İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi · doi:10.33715/inonusaglik.1905868
A Point-of-Care Hormone Monitoring Platform for Postpartum Health Assessment
McDonald, A., Torres, A., & Warneke, F. (2026) · Scholar Commons (Santa Clara University)
IMPUTABILITA’ E DEPRESSIONE POST-PARTUM
QUIRINI, F. F. (2026) · Electronic Theses and Dissertations Repository (University of Pisa)
khairani, M., Hasanat, N. U., Utami, D. M. S., & Safuni, N. (2026) · Insight Jurnal Ilmiah Psikologi · doi:10.26486/psikologi.v28i1.5429
Wang, Y., Huang, W., 徐旭娟, & Gu, J. H. (2026) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.71426
Marques, R. A. D. S. (2017) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Ahmad, M., Sechi, C., Fadda, R., Congiu, S., Lucarelli, L., & Vismara, L. (2026) · Infant Behavior and Development · doi:10.1016/j.infbeh.2026.102269
Tian, Y., & Li, H. (2026) · Journal of Health Psychology · doi:10.1177/13591053261495654
Perinatal mental health care: current evidence and future directions
Pinto, T. M., & Costa, R. A. (2026) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2026.102786
Vejdani, R., & Asgharzadeh, A. (2026) · معنویتپژوهی در علوم سلامت. · doi:10.34172/srhs.2026.002
Chen, W., Kaddoura, R., Hassan, Z., Mousa, M., Ameri, K. S. A., Meqbel, R., Alramahi, R. J., Azzabi, S. E., Carew, H. I., Muad, M., et al. (2026) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-026-03235-9
Metadata
- Authors
- Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C.
- Affiliations
- University of California, Irvine (US)
- Department of Psychology, University of California, Los Angeles, California 90095;, ,
- University of California, Los Angeles (US)
- Corresponding author
- Yim, Ilona S.
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2015-03-28
- Volume
- 11
- Issue
- 1
- Pages
- 99-137
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC5659274
- OpenAlex
- W2098303391
- Cited by
- 749
- References
- 236
- Citations by year
- 2026: 74 · 2025: 86 · 2024: 64 · 2023: 91 · 2022: 79 · 2021: 87 · 2020: 107 · 2019: 73 · 2018: 37 · 2017: 21 · 2016: 22 · 2015: 8
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (15750, NIMH T32, MH T32 15750, T32MH015750)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Keywords
- postpartum depression, biopsychosocial model, risk factors, inflammation, genetic susceptibility, psychosocial factors, life events, chronic strain, relationship quality, social support, postpartum depressive symptoms, etiology
- MeSH terms
- Endocrine System Diseases, Female, Humans, Pregnancy, Psychology, Risk Factors, Depression, Postpartum
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