The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
The Relationship Between the Human Genome and Microbiome Comes into View
Open accessAbstract
The body's microbiome, composed of microbial cells that number in the trillions, is involved in human health and disease in ways that are just starting to emerge. The microbiome is assembled at birth, develops with its host, and is greatly influenced by environmental factors such as diet and other exposures. Recently, a role for human genetic variation has emerged as also influential in accounting for interpersonal differences in microbiomes. Thus, human genes may influence health directly or by promoting a beneficial microbiome. Studies of the heritability of gut microbiotas reveal a subset of microbes whose abundances are partly genetically determined by the host. However, the use of genome-wide association studies (GWASs) to identify human genetic variants associated with microbiome phenotypes has proven challenging. Studies to date are small by GWAS standards, and cross-study comparisons are hampered by differences in analytical approaches. Nevertheless, associations between microbes or microbial genes and human genes have emerged that are consistent between human populations. Most notably, higher levels of beneficial gut bacteria called Bifidobacteria are associated with the human lactase nonpersister genotype, which typically confers lactose intolerance, in several different human populations. It is time for the microbiome to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome in order to predict human disease susceptibility.
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“Differences in microbiome diversity have been shown to be partially attributed by genotype and sex [79–83].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [80]
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1 retracted
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RetractedA core gut microbiome in obese and lean twins
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Self-citationHuman Genetics Shape the Gut Microbiome
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Self-citationGut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
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Cited by
Sorted by citations
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859
Integrative omics for health and disease
Karczewski, K. J., & Snyder, M. P. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2018.4 · Cited by 1,158
Diet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879
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Olm, M. R., Crits-Christoph, A., Bouma-Gregson, K., Firek, B. A., Morowitz, M. J., & Banfield, J. F. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00797-0 · Cited by 537
Metadata
- Authors
- Goodrich, J. K., Davenport, E. R., Clark, A. G., & Ley, R. E.
- Affiliations
- Cornell University (US)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2017-11-27
- Volume
- 51
- Issue
- 1
- Pages
- 413-433
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- PMC
- PMC5744868
- OpenAlex
- W2611069262
- Cited by
- 311
- References
- 74
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 35 · 2023: 30 · 2022: 37 · 2021: 52 · 2020: 62 · 2019: 43 · 2018: 20 · 2017: 1
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK109595, R01DK093595)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- human microbiome, gut microbiota, host genetics, genetic variation, genome-wide association study, Bifidobacterium, lactase non-persistence, lactose intolerance, disease susceptibility
- MeSH terms
- Gastrointestinal Microbiome, Human Genetics, Amyotrophic Lateral Sclerosis, Bifidobacterium, Diet, Genotype, Humans, Lactose Intolerance, Obesity, Phenotype, Schizophrenia, Genetic Variation, Genome, Human, Quantitative Trait, Heritable, Gastrointestinal Tract, Genome-Wide Association Study
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- Goodrich, J. K., Davenport, E. R., Clark, A. G., & Ley, R. E. (2017). The Relationship Between the Human Genome and Microbiome Comes into View. Annual Review of Genetics. https://doi.org/10.1146/annurev-genet-110711-155532
