Cited by 213Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Microglia in Brain Development, Homeostasis, and Neurodegeneration

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Bohlen, Christopher J., Friedman, Brad A., Dejanovic, Borislav, Sheng, Morgan·2019·Annual Review of Genetics

DOI 10.1146/annurev-genet-112618-043515

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Abstract

Advances in human genetics have implicated a growing number of genes in neurodegenerative diseases, providing insight into pathological processes. For Alzheimer disease in particular, genome-wide association studies and gene expression studies have emphasized the pathogenic contributions from microglial cells and motivated studies of microglial function/dysfunction. Here, we summarize recent genetic evidence for microglial involvement in neurodegenerative disease with a focus on Alzheimer disease, for which the evidence is most compelling. To provide context for these genetic discoveries, we discuss how microglia influence brain development and homeostasis, how microglial characteristics change in disease, and which microglial activities likely influence the course of neurodegeneration. In all, we aim to synthesize varied aspects of microglial biology and highlight microglia as possible targets for therapeutic interventions in neurodegenerative disease.

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1 retracted

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Self-citation
Additional file 5 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555684
Additional file 17 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555720
Additional file 9 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555696
Additional file 8 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555693
Additional file 15 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555714
Additional file 16 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555717
Additional file 6 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555687
Additional file 7 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555690
Additional file 11 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555702
Additional file 4 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555681
Additional file 1 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555672
Additional file 13 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555708
Additional file 2 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555675
Additional file 3 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555678
Additional file 10 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555699
Additional file 18 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555723
Additional file 12 of Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Kim, D. W., Tu, K. J., Wei, A., Lau, A., Gonzalez-Gil, A., Cao, T., Braunstein, K. E., Ling, J. P., Troncoso, J. C., Wong, P. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26555705

Authors: Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M.
Affiliations: Genentech (US)
ORCID: Bohlen, Christopher J.
Friedman, Brad A.
Dejanovic, Borislav
Sheng, Morgan
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 2019-12-03
Volume: 53
Issue: 1
Pages: 263-288
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev-genet-112618-043515
OpenAlex: W2972808567
Cited by: 212
References: 165
Citations by year: 2026: 17 · 2025: 29 · 2024: 53 · 2023: 36 · 2022: 33 · 2021: 26 · 2020: 18
FWCI: 1.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Annual Review of Genetics (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: microglia, Alzheimer's disease, neurodegeneration, brain development, brain homeostasis, microglial dysfunction, genetic risk factors, genome-wide association study, therapeutic target
MeSH terms: Aging, Alzheimer Disease, Animals, Brain, Central Nervous System, Complement Pathway, Classical, Gene Expression Regulation, Homeostasis, Humans, Macrophages, Transforming Growth Factor beta, Microglia, Neurodegenerative Diseases, Genetic Predisposition to Disease, Plaque, Amyloid

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